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A human CD3 (show CD3E Proteins) transgene that encodes full length CD3delta (show CD3D Proteins) and a truncated but functional form of CD3epsilon (show CD3E Proteins) restored the defective preTCR function in not only CD3epsilon (show CD3E Proteins)- but CD3gamma- and CD3gammadelta-deficient mice as well.
CD3delta and CD3gamma play a different role in humans and mice in pre-TCR and TCR function during alphabeta T-cell development
These animals had also a lower number of apoptotic graft infiltrating T cells, whereas the expression of intracellular interferon-gamma (show IFNG Proteins) in CD3CD4 T cells was increased.
CD3delta (show CD3D Proteins) transgene rescues gammadelta T cell development in mice lacking both mouse CD3delta (show CD3D Proteins) and CD3gamma.
Our study thus identifies an important role of CD3gamma-mediated TCR down-regulation in T cell homeostasis.
CD3 (show CD3 Proteins) showed a positive correlation with tryptase (show TPSAB1 Proteins) and microvascular density, while multiple regression analysis efficaciously predicted microvascular density depending on CD3 (show CD3 Proteins) and tryptase (show TPSAB1 Proteins) as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in Diffuse large B cell lymphoma patients.
The study identifies an important role of the CD3gamma dileucine motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling.
HER2 (show ERBB2 Proteins)/CD3 (show CD3 Proteins) BsAb efficiently inhibited the growth of breast cancer tissue by activating and inducing the proliferation of tumor tissue infiltrating lymphocytes.
The docking site for CD3 (show CD3 Proteins) subunits on the T Cell receptor beta chain has been identified by solution NMR.
Low cord blood Foxp3 (show FOXP3 Proteins)/CD3gamma mRNA ratios are highly predictive for early allergy development.
Data indicate that the high CD68 (show CD68 Proteins)/CD3 (show CD3 Proteins) ratio identifies a bad prognosis group among muscle-invasive urothelial carcinoma (UC). cases.
Case Report: T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15 (show CDKN2B Proteins);q32) [TCRgamma-TCL1A (show TCL1A Proteins) translocation] confirmed by FISH.
The results suggest that CD3G should be studied as a candidate gene for autoimmunity and that CD3gamma deficiency should be considered among other primary immunodeficiencies with predominantly autoimmune manifestations.
The surface TCR expression of primary alphabeta and gammadelta T cells from healthy donors carrying a single null or leaky mutation in CD3G (gamma+/-) or CD3D (show CD3D Proteins) (delta+/-, delta+/leaky) with that of normal controls, were compared.
In conclusion, TCR-gamma expression seems to be rare and is confined to cytotoxic primary cutaneous T-cell lymphomas
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency.
T-cell receptor T3 gamma chain
, T-cell surface glycoprotein CD3 gamma chain
, CD3 antigen, gamma polypeptide
, CD3 gamma-chain
, CD3 molecule, gamma polypeptide
, CD3g antigen, gamma polypeptide (TiT3 complex)
, CD3g molecule, epsilon (CD3-TCR complex)
, T-cell antigen receptor complex, gamma subunit of T3
, CD3G antigen, gamma polypeptide
, antigen CD3G, gamma polypeptide
, CD3 antigen gamma chain
, CD3 gamma chain