anti-Human CD4 antibody for ELISA (Detection)

Recommended CD4 Antibody (supplied by: Log in to see )

Antigen
CD4 Molecule (CD4) Antibodies
  • cd4
  • L3T4
  • Ly-4
  • CD4mut
  • W3/25
  • p55
  • CD4 molecule
  • CD4 antigen
  • T-cell surface glycoprotein CD4
  • Cd4 molecule
  • CD4
  • cd4
  • Cd4
Reactivity
Human
1219
632
234
68
67
40
36
27
26
22
21
19
18
16
15
15
13
10
10
9
7
6
5
5
5
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
Host
Mouse
1376
587
281
11
4
1
1
1
Clonality
Monoclonal
Conjugate
This CD4 antibody is conjugated to Biotin
266
227
169
103
49
48
46
40
36
34
34
30
27
25
21
21
19
19
18
18
18
18
16
15
15
13
13
13
11
9
9
8
6
5
5
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA (Detection), ELISpot (Detection) (ELISPOT (Detection)), Intracellular Flow Cytometry (ICFC)
1744
490
445
353
323
309
157
155
88
78
39
38
31
30
30
25
17
14
14
11
9
9
6
6
5
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
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Catalog No. ABIN2661070
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General

Antigen CD4 Molecule (CD4) Antibodies
Reactivity Human
(1219), (632), (234), (68), (67), (40), (36), (27), (26), (22), (21), (19), (18), (16), (15), (15), (13), (10), (10), (9), (7), (6), (5), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Host Mouse
(1376), (587), (281), (11), (4), (1), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD4 antibody is conjugated to Biotin
(266), (227), (169), (103), (49), (48), (46), (40), (36), (34), (34), (30), (27), (25), (21), (21), (19), (19), (18), (18), (18), (18), (16), (15), (15), (13), (13), (13), (11), (9), (9), (8), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA (Detection), ELISpot (Detection) (ELISPOT (Detection)), Intracellular Flow Cytometry (ICFC)
(1744), (490), (445), (353), (323), (309), (157), (155), (88), (78), (39), (38), (31), (30), (30), (25), (17), (14), (14), (11), (9), (9), (6), (6), (5), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 9 references available
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Product Details anti-CD4 Antibody

Target Details CD4 Application Details Handling ProductDetails: References for anti-CD4 antibody (ABIN2661070) Images
Cross-Reactivity Chimpanzee
Purification The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Clone RPA-T4
Isotype IgG1 kappa

Target Details CD4

Product Details anti-CD4 Antibody Application Details Handling ProductDetails: References for anti-CD4 antibody (ABIN2661070) Images back to top
Antigen
Alternative Name CD4 (CD4 Antibody Abstract)
Background CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules, and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16.
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Maintenance of Protein Location, CXCR4-mediated Signaling Events

Application Details

Product Details anti-CD4 Antibody Target Details CD4 Handling ProductDetails: References for anti-CD4 antibody (ABIN2661070) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD4 Antibody Target Details CD4 Application Details ProductDetails: References for anti-CD4 antibody (ABIN2661070) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

ProductDetails: References for anti-CD4 antibody (ABIN2661070)

Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling Images back to top
Background publications

Zenaro, Donini, Dusi: "Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN." in: Journal of leukocyte biology, Vol. 86, Issue 6, pp. 1393-401, 2009

Lan, Cheng, Lian, Tsuneyama, Yang, Moritoki, Chuang, Nakamura, Saito, Shimoda, Tanaka, Bowlus, Takano, Ansari, Coppel, Gershwin: "Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis." in: Hepatology (Baltimore, Md.), Vol. 43, Issue 4, pp. 729-37, 2006

Mack, Tucker, Sokol, Karrer, Kotzin, Whitington, Miller: "Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation." in: Pediatric research, Vol. 56, Issue 1, pp. 79-87, 2004

Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000

Friedman, Shimizu, Smith, Colvin, Seebach, Sachs, Iacomini: "Human CD4+ T cells mediate rejection of porcine xenografts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 9, pp. 5256-62, 1999

Moir, Lapointe, Malaspina, Ostrowski, Cole, Chun, Adelsberger, Baseler, Hwu, Fauci et al.: "CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral ..." in: Journal of virology, Vol. 73, Issue 10, pp. 7972-80, 1999

Center, Kornfeld, Cruikshank: "Interleukin 16 and its function as a CD4 ligand." in: Immunology today, Vol. 17, Issue 10, pp. 476-81, 1997

Gaubin, Autiero, Houlgatte, Basmaciogullari, Auffray, Piatier-Tonneau: "Molecular basis of T lymphocyte CD4 antigen functions." in: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, Vol. 34, Issue 9, pp. 723-8, 1997

Deng, Bell, Huie, Pinto, Hunt, Stinson, Sibley, Hall, Valantine: "Cardiac allograft vascular disease. Relationship to microvascular cell surface markers and inflammatory cell phenotypes on endomyocardial biopsy." in: Circulation, Vol. 91, Issue 6, pp. 1647-54, 1995

Images

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Supplier Images
Flow Cytometry (FACS) image for anti-CD4 Molecule (CD4) antibody (Biotin) (ABIN2661070) anti-CD4 Molecule (CD4) antibody (Biotin)