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|Application / Reactivity||Human|
|Activation (Act)||3 Antibodies|
|Biochemical Assay (BCA)||6 Antibodies|
|Blocking Antibody (Inhibition)||1 Antibodies|
|Blocking Reagent (BR)||9 Antibodies|
|Complement Mediated Cell Depletion (CMCD)||2 Antibodies|
|Depletion (Dep)||4 Antibodies|
|ELISA (Capture)||1 Antibodies|
|ELISA (Detection)||1 Antibodies|
|ELISpot (Detection) (ELISPOT (Detection))||1 Antibodies|
|Enzyme Immunoassay (EIA)||6 Antibodies|
|Flow Cytometry (FACS)||570 Antibodies|
|Functional Studies (Func)||31 Antibodies|
|Immunochromatography (IC)||3 Antibodies|
|Immunocytochemistry (ICC)||38 Antibodies|
|Immunofluorescence (IF)||92 Antibodies|
|Antigen||CD4 Molecule (CD4) Antibodies|
|Conjugate||This CD4 antibody is conjugated to Biotin Alternatives|
ELISA (Detection), ELISpot (Detection) (ELISPOT (Detection)), Intracellular Flow Cytometry (ICFC)
|9 references available|
|Supplier||Log in to see|
Product Details anti-CD4 AntibodyTarget Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN2661070) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.|
Target Details CD4Product Details anti-CD4 Antibody Application Details Handling References for anti-CD4 Antibody (ABIN2661070) Images back to top
|Alternative Name||CD4 (CD4 Antibody Abstract)|
|Background||CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the Ig superfamily, recognizes antigens associated with MHC class II molecules, and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16.|
|Research Area||Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD4 Antibody Target Details CD4 Handling References for anti-CD4 Antibody (ABIN2661070) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD4 Antibody Target Details CD4 Application Details References for anti-CD4 Antibody (ABIN2661070) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-CD4 Antibody (ABIN2661070)Product Details anti-CD4 Antibody Target Details CD4 Application Details Handling Images back to top
Zenaro, Donini, Dusi: "Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN." in: Journal of leukocyte biology, Vol. 86, Issue 6, pp. 1393-401, 2009 (PubMed).
Lan, Cheng, Lian et al.: "Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis." in: Hepatology (Baltimore, Md.), Vol. 43, Issue 4, pp. 729-37, 2006 (PubMed).
Mack, Tucker, Sokol et al.: "Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation." in: Pediatric research, Vol. 56, Issue 1, pp. 79-87, 2004 (PubMed).
Yoshino, Ami, Terao et al.: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).
Moir, Lapointe, Malaspina et al.: "CD40-Mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: potential role of B lymphocytes as a viral ..." in: Journal of virology, Vol. 73, Issue 10, pp. 7972-80, 1999 (PubMed).
Friedman, Shimizu, Smith et al.: "Human CD4+ T cells mediate rejection of porcine xenografts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 9, pp. 5256-62, 1999 (PubMed).
Center, Kornfeld, Cruikshank: "Interleukin 16 and its function as a CD4 ligand." in: Immunology today, Vol. 17, Issue 10, pp. 476-81, 1997 (PubMed).
Gaubin, Autiero, Houlgatte et al.: "Molecular basis of T lymphocyte CD4 antigen functions." in: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, Vol. 34, Issue 9, pp. 723-8, 1997 (PubMed).
Deng, Bell, Huie et al.: "Cardiac allograft vascular disease. Relationship to microvascular cell surface markers and inflammatory cell phenotypes on endomyocardial biopsy." in: Circulation, Vol. 91, Issue 6, pp. 1647-54, 1995 (PubMed).
ImagesProduct Details anti-CD4 Antibody Target Details CD4 Application Details Handling References for anti-CD4 Antibody (ABIN2661070) back to top