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|Antigen||CD8a Molecule (CD8A) Antibodies|
|Reactivity||Cat (Feline) Alternatives|
|Conjugate||This CD8 antibody is conjugated to Biotin Alternatives|
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC)
|2 references available|
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Product Details anti-CD8 AntibodyTarget Details CD8 Application Details Handling References for anti-CD8 Antibody (ABIN135498) Images
|Characteristics||The antibody detects: Feline CD8, Mr 70 kDa (38/31 kDa under reducing conditions).|
Target Details CD8Product Details anti-CD8 Antibody Application Details Handling References for anti-CD8 Antibody (ABIN135498) Images back to top
|Alternative Name||CD8 (CD8A Antibody Abstract)|
|Background||Feline CD8, a member of the immunoglobulin superfamily of cell surface receptors, is a type II transmembrane glycoprotein that is expressed as a heterodimer on the suppressor/cytotoxic subpopulation of peripheral T lymphocytes. It is present on approximately 63 % of thymocytes, 9 % of splenocytes, 20 % of lymph node cells, and 15 % of peripheral blood lymphocytes. CD8 functions as a co-receptor with MHC Class I-restricted T cell receptors in antigen recognition.|
|Research Area||Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD8 Antibody Target Details CD8 Handling References for anti-CD8 Antibody (ABIN135498) Images back to top
1 µg/10^6 cells
Representative data are included in this product insert.
Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
|Sample Volume||1 mL|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD8 Antibody Target Details CD8 Application Details References for anti-CD8 Antibody (ABIN135498) Images back to top
|Buffer||Product is supplied as 0.5 mg in 1.0 mL of PBS / NaN3.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.
References for anti-CD8 Antibody (ABIN135498)Product Details anti-CD8 Antibody Target Details CD8 Application Details Handling Images back to top
Dean, Quackenbush, Ackley, Cooper, Hoover: "Flow cytometric analysis of T-lymphocyte subsets in cats." in: Veterinary immunology and immunopathology, Vol. 28, Issue 3-4, pp. 327-35, 1991
Klotz, Cooper: "A feline thymocyte antigen defined by a monoclonal antibody (FT2) identifies a subpopulation of non-helper cells capable of specific cytotoxicity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 136, Issue 7, pp. 2510-4, 1986
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