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|Antigen||CD8a Molecule (CD8A) Antibodies|
|Reactivity||Cat (Feline) Alternatives|
|Conjugate||This CD8 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
|2 references available|
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Product Details anti-CD8 AntibodyTarget Details CD8 Application Details Handling References for anti-CD8 Antibody (ABIN371320) Images
|Specificity||This antibody recognizes Feline CD8 (Mr. 70 kDa) (38/31 kDa under reducing conditions).|
|Characteristics||Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain|
Target Details CD8Product Details anti-CD8 Antibody Application Details Handling References for anti-CD8 Antibody (ABIN371320) Images back to top
|Alternative Name||CD8 (CD8A Antibody Abstract)|
|Background||The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2|
|Research Area||Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD8 Antibody Target Details CD8 Handling References for anti-CD8 Antibody (ABIN371320) Images back to top
Flow Cytometry. (Ref.1-2)Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections only). Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD8 Antibody Target Details CD8 Application Details References for anti-CD8 Antibody (ABIN371320) Images back to top
|Buffer||100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
References for anti-CD8 Antibody (ABIN371320)Product Details anti-CD8 Antibody Target Details CD8 Application Details Handling Images back to top
Dean, Quackenbush, Ackley, Cooper, Hoover: "Flow cytometric analysis of T-lymphocyte subsets in cats." in: Veterinary immunology and immunopathology, Vol. 28, Issue 3-4, pp. 327-35, 1991
Klotz, Cooper: "A feline thymocyte antigen defined by a monoclonal antibody (FT2) identifies a subpopulation of non-helper cells capable of specific cytotoxicity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 136, Issue 7, pp. 2510-4, 1986