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anti-Human CD8 antibody for Biochemical Assay

Recommended CD8 Antibody (supplied by: Log in to see )

Antigen
CD8a Molecule (CD8A) Antibodies
  • BB154331
  • CD8
  • cd8
  • Leu2
  • LOC100136450
  • Ly-2
  • Ly-35
  • Ly-B
  • Lyt-2
  • MAL
  • p32
  • RHACD8-4
  • zgc:136643
Reactivity
Human
1058
532
167
68
47
40
25
22
20
20
19
16
15
13
12
12
11
11
10
10
8
8
5
3
3
2
2
2
2
1
1
1
Host
Mouse
1285
512
206
Clonality
Monoclonal
Conjugate
This CD8 antibody is conjugated to APC
259
217
142
85
52
42
40
39
30
30
29
28
27
26
25
25
25
25
25
21
21
18
18
17
11
10
10
10
8
6
6
5
4
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
1618
452
356
343
285
282
255
238
214
37
33
25
23
17
14
10
6
6
6
6
5
4
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Supplier
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Catalog No. ABIN2658732
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008858258 ABIN2664826 BCA Mouse IgG1 kappa Log in to see SK1 7
0.0008858258 ABIN2658733 BCA APC Mouse IgG1 kappa Log in to see HIT8a 4

Top referenced anti-CD8 antibody for Biochemical Assay

  • Human Monoclonal CD8 Primary Antibody for BCA - ABIN2658732 (4 Publications): Awasthi, Lubinski, Shaw, Barrett, Cai, Wang, Betts, Kingsley, Distefano, Balliet, Flynn, Casimiro, Bryan, Friedman et al.: Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent ... in Journal of virology 2011 (PubMed)

  • Human Monoclonal CD8 Primary Antibody for BCA - ABIN2658733 (4 Publications): Ernst, Zimara, Hanses, Männel, Seelbach-Göbel, Wege: Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis. in Infection and immunity 2013 (PubMed)

  • Human Monoclonal CD8 Primary Antibody for BCA - ABIN2664826 (7 Publications): Campanelli, Palermo, Garbelli, Mantovani, Lucchi, Necker, Lantelme, Giachino: Human CD8 co-receptor is strictly involved in MHC-peptide tetramer-TCR binding and T cell activation. in International immunology 2001 (PubMed)

Similar anti-CD8 Antibodies

Application / Reactivity Human
Biochemical Assay (BCA) 3 Antibodies
Blocking Antibody (Inhibition) 1 Antibodies
Blocking Reagent (BR) 4 Antibodies
Co-Stimulation (CoSt) 2 Antibodies
Cytotoxicity Test (CyTox) 7 Antibodies
ELISA 181 Antibodies
ELISA (Detection) 1 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 824 Antibodies
Fluorescence Microscopy (FM) 1 Antibodies
Functional Studies (Func) 5 Antibodies
Immunochromatography (IC) 10 Antibodies
Immunocytochemistry (ICC) 163 Antibodies
Immunofluorescence (IF) 187 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 188 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 10 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 2 Antibodies

General

Antigen CD8a Molecule (CD8A) Antibodies
Reactivity Human
(1058), (532), (167), (68), (47), (40), (25), (22), (20), (20), (19), (16), (15), (13), (12), (12), (11), (11), (10), (10), (8), (8), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Host Mouse
(1285), (512), (206)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD8 antibody is conjugated to APC
(259), (217), (142), (85), (52), (42), (40), (39), (30), (30), (29), (28), (27), (26), (25), (25), (25), (25), (25), (21), (21), (18), (18), (17), (11), (10), (10), (10), (8), (6), (6), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(1618), (452), (356), (343), (285), (282), (255), (238), (214), (37), (33), (25), (23), (17), (14), (10), (6), (6), (6), (6), (5), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-CD8 Antibody

Target Details CD8 Application Details Handling References for anti-CD8 Antibody (ABIN2658732) Images
Cross-Reactivity Chimpanzee, Marmoset
Purification The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Clone HIT8a
Isotype IgG1 kappa

Target Details CD8

Product Details anti-CD8 Antibody Application Details Handling References for anti-CD8 Antibody (ABIN2658732) Images back to top
Antigen
Alternative Name CD8a (CD8A Antibody Abstract)
Background CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Research Area CD Antigens, Surface Receptors of Immune Cells, Major Histocompatibility Complex (MHC)
Pathways TCR Signaling

Application Details

Product Details anti-CD8 Antibody Target Details CD8 Handling References for anti-CD8 Antibody (ABIN2658732) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD8 Antibody Target Details CD8 Application Details References for anti-CD8 Antibody (ABIN2658732) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-CD8 Antibody (ABIN2658732)

Product Details anti-CD8 Antibody Target Details CD8 Application Details Handling Images back to top
Background publications

Ernst, Zimara, Hanses, Männel, Seelbach-Göbel, Wege: "Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis." in: Infection and immunity, Vol. 81, Issue 5, pp. 1520-31, 2013

Coppieters, Dotta, Amirian, Campbell, Kay, Atkinson, Roep, von Herrath: "Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients." in: The Journal of experimental medicine, Vol. 209, Issue 1, pp. 51-60, 2012

Suzuki, Kubota, Miyazaki, Ishikawa, Ebisawa, Hirohata, Ogura, Mizusawa, Imai, Miyasaka, Nanki: "Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity." in: Arthritis research & therapy, Vol. 14, Issue 2, pp. R48, 2012

Awasthi, Lubinski, Shaw, Barrett, Cai, Wang, Betts, Kingsley, Distefano, Balliet, Flynn, Casimiro, Bryan, Friedman et al.: "Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent ..." in: Journal of virology, Vol. 85, Issue 20, pp. 10472-86, 2011

Images

Product Details anti-CD8 Antibody Target Details CD8 Application Details Handling References for anti-CD8 Antibody (ABIN2658732) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-CD8 antibody (CD8a Molecule)  (APC) (ABIN2658732) anti-CD8a Molecule (CD8A) antibody (APC)