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anti-Human CD8 antibody for Blocking Antibody

Recommended CD8 Antibody (supplied by: Log in to see )

Antigen
CD8a Molecule (CD8A) Antibodies
  • BB154331
  • CD8
  • cd8
  • Leu2
  • LOC100136450
  • Ly-2
  • Ly-35
  • Ly-B
  • Lyt-2
  • MAL
  • p32
  • RHACD8-4
  • zgc:136643
Reactivity
Human
765
404
130
68
28
27
25
20
20
16
15
12
12
11
11
10
10
9
8
8
3
3
2
2
2
2
1
1
1
Host
Mouse
960
391
161
Clonality
Monoclonal
Conjugate
This CD8 antibody is un-conjugated
243
190
122
86
30
30
27
18
18
17
16
15
13
11
10
10
10
9
8
5
5
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Blocking Antibody (Inhibition), Immunostaining (ISt)
1178
282
232
188
136
111
105
81
69
36
33
25
23
17
14
10
7
6
6
6
5
4
3
2
2
2
1
1
1
1
1
1
1
1
Supplier
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Catalog No. ABIN1002127
$ 374.22
Plus shipping costs $45.00

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General

Antigen CD8a Molecule (CD8A) Antibodies
Reactivity Human
(765), (404), (130), (68), (28), (27), (25), (20), (20), (16), (15), (12), (12), (11), (11), (10), (10), (9), (8), (8), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Host Mouse
(960), (391), (161)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD8 antibody is un-conjugated
(243), (190), (122), (86), (30), (30), (27), (18), (18), (17), (16), (15), (13), (11), (10), (10), (10), (9), (8), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Blocking Antibody (Inhibition), Immunostaining (ISt)
(1178), (282), (232), (188), (136), (111), (105), (81), (69), (36), (33), (25), (23), (17), (14), (10), (7), (6), (6), (6), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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Product Details anti-CD8 Antibody

Target Details CD8 Application Details Handling Images
Predicted Reactivity Human CD8
Purification Ion exchange chromatography
Immunogen Purified human PBL CD8+ T cells
Clone HCD8
Isotype IgG2a

Target Details CD8

Product Details anti-CD8 Antibody Application Details Handling Images back to top
Antigen
Alternative Name CD8 (CD8A Antibody Abstract)
Background CD8 belongs to the immunoglobulin superfamily and occurs either as a disulfide-linked homodimer or homomultimer of two 34 kDa subunits (CD8-alpha) or as a heterodimer complexed with another protein named CD8-beta of which there are multiple forms arising by alternative splicing of its mRNA. CD8 functions as an adhesion molecule that binds MHC class 1 molecules. Moreover, it is required for the development of cytotoxic T-cells but not for the development of T-helper cells. CD8(+) cells are cytotoxic T-lymphocytes which are capable of lysing target cells by direct cell contact. Antibodies against CD8 can block the killing activity of cytotoxic cells by inhibiting target cell adhesion. In CD4(+) cells the expression of CD8 can be induced by IL4.
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling

Application Details

Product Details anti-CD8 Antibody Target Details CD8 Handling Images back to top
Application Notes Staining and blocking antibody, weakly cytotoxic. For staining, use 10 ml/10⁶ cells. Titer for cytotoxicity and blocking should be determined individually by the investigator. Antibody might also be suited for other applications not tested so far.
Restrictions For Research Use only

Handling

Product Details anti-CD8 Antibody Target Details CD8 Application Details Images back to top
Format Lyophilized
Buffer NA
Handling Advice Please Note: Always centrifuge product briefly before opening vial. Reconstitute with 0.5 ml sterile H20 or PBS to give a 1 mg/ml concentration. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Protein concentration: 1 mg/ml (after reconstitution).
Storage 4 °C/-20 °C