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anti-Pig (Porcine) CD8 antibody for Cytotoxicity Test

Recommended CD8 Antibody (supplied by: Log in to see )

Antigen
CD8a Molecule (CD8A) Antibodies
  • BB154331
  • CD8
  • cd8
  • Leu2
  • LOC100136450
  • Ly-2
  • Ly-35
  • Ly-B
  • Lyt-2
  • MAL
  • p32
  • RHACD8-4
  • zgc:136643
Reactivity
Pig (Porcine)
1026
538
164
73
47
40
22
22
20
20
19
16
15
13
13
12
12
12
11
11
10
10
8
3
3
2
2
2
2
1
1
1
1
Host
Mouse
1276
510
193
1
Clonality
Monoclonal
Conjugate
This CD8 antibody is un-conjugated
258
217
138
81
56
44
41
37
33
29
28
28
26
25
24
24
24
24
20
20
19
17
16
14
12
11
10
10
10
6
6
4
4
4
4
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Cytotoxicity Test (CyTox), Flow Cytometry (FACS), Immunoprecipitation (IP)
1617
439
351
336
269
262
240
235
199
39
37
25
23
17
14
11
10
7
7
6
6
6
5
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Supplier
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Catalog No. ABIN371299
$ 489.50
Plus shipping costs $45.00

Top referenced anti-CD8 antibody for Cytotoxicity Test

Similar anti-CD8 Antibodies

Application / Reactivity Pig (Porcine)
Blocking Peptide (BP) 1 Antibodies
Cytotoxicity Test (CyTox) 1 Antibodies
Flow Cytometry (FACS) 41 Antibodies
Immunohistochemistry (IHC) 10 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2 Antibodies
Immunoprecipitation (IP) 24 Antibodies
Neutralization (Neut) 1 Antibodies

General

Antigen CD8a Molecule (CD8A) Antibodies
Reactivity Pig (Porcine)
(1026), (538), (164), (73), (47), (40), (22), (22), (20), (20), (19), (16), (15), (13), (13), (12), (12), (12), (11), (11), (10), (10), (8), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Host Mouse
(1276), (510), (193), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD8 antibody is un-conjugated
(258), (217), (138), (81), (56), (44), (41), (37), (33), (29), (28), (28), (26), (25), (24), (24), (24), (24), (20), (20), (19), (17), (16), (14), (12), (11), (10), (10), (10), (6), (6), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Cytotoxicity Test (CyTox), Flow Cytometry (FACS), Immunoprecipitation (IP)
(1617), (439), (351), (336), (269), (262), (240), (235), (199), (39), (37), (25), (23), (17), (14), (11), (10), (7), (7), (6), (6), (6), (5), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-CD8 Antibody

Target Details CD8 Application Details Handling References for anti-CD8 Antibody (ABIN371299) Images
Specificity This antibody reacts with Porcine CD8 alpha (Mr. 32-34 kDa). (Ref-1-3)
Characteristics Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain
Purification Purified
Clone 11-02-76
Isotype IgG2a

Target Details CD8

Product Details anti-CD8 Antibody Application Details Handling References for anti-CD8 Antibody (ABIN371299) Images back to top
Antigen
Alternative Name CD8 (CD8A Antibody Abstract)
Background The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 is expressed on most thymocytes and approximately 1/3 of peripheral blood T cells in humans. CD8 alpha/beta heterodimers are expressed only on TCR alpha/beta T cells, whereas CD8 alpha homodimers can be expressed on alpha/beta and gamma/delta T cells and some NK cells in humans. The pattern of expression in other species has not been well documented.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
Gene ID 396627
UniProt Q6R2U9
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling

Application Details

Product Details anti-CD8 Antibody Target Details CD8 Handling References for anti-CD8 Antibody (ABIN371299) Images back to top
Application Notes Flow Cytometry. (Ref.1-3)Immunoprecipitation Cytotoxicity Assays (Ref.1,2)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-CD8 Antibody Target Details CD8 Application Details References for anti-CD8 Antibody (ABIN371299) Images back to top
Concentration 0.5 mg/mL
Buffer 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months

References for anti-CD8 Antibody (ABIN371299)

Product Details anti-CD8 Antibody Target Details CD8 Application Details Handling Images back to top
Background publications

Yamada, Sachs, DerSimonian: "Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 11, pp. 5249-56, 1995

Smith, Sablinski, Arn, Myers, Rosengard, Uckun, Sachs: "In vivo treatment with monoclonal antibodies directed against CD4 and CD8 antigens in miniature swine." in: Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy, Vol. 16, Issue 2, pp. 105-14, 1995

Pescovitz, Lunney, Sachs: "Preparation and characterization of monoclonal antibodies reactive with porcine PBL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 133, Issue 1, pp. 368-75, 1984