Browse our CD8 Proteins (CD8A)

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CD8a Molecule Proteins (CD8A)
On are 26 CD8a Molecule (CD8A) Proteins from 7 different suppliers available. Additionally we are shipping CD8 Antibodies (1348) and CD8 Kits (32) and many more products for this protein. A total of 1425 CD8 products are currently listed.
BB154331, CD8, Leu2, LOC100136450, Ly-2, Ly-35, Ly-B, Lyt-2, MAL, p32, RHACD8-4, zgc:136643
list all proteins Gene Name GeneID UniProt
CD8A 12525 P01731
CD8A 925 P01732
CD8A 24930 P07725

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CD8 Proteins (CD8A) by Origin

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More Proteins for CD8 Interaction Partners

Mouse (Murine) CD8a Molecule (CD8A) interaction partners

  1. The generation of cancer-specific CD8(+) CD69 (show CD69 Proteins)(+)-expressing lymphocytes that inhibit colon cancer growth has been described.

  2. TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.

  3. Batf3 (show BATF3 Proteins) deficiency is not critical for the generation of CD8alpha dendritic cells

  4. Lck (show LCK Proteins)-CD8 interaction is required for initial CD8 recruitment.

  5. Brd1 (show BRD1 Proteins)-mediated Hbo1 (show MYST2 Proteins) activity is crucial for efficient activation of CD8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 enhancers.

  6. Ly49E is expressed on a high proportion of CD8alphaalpha-positive intestinal intraepithelial lymphocytes.

  7. Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.

  8. Data indicate that orphan G-protein-coupled receptor GPR18 is required for the normal homeostasis of CD8alphaalpha gammadeltaT and alphabetaT and CD8alphabeta intestinal intraepithelial lymphocyte compartment.

  9. CD8alpha DCs, rather than CD8 T cells, are responsible for enhanced viral latency and recurrences.

  10. Downregulation of CD8 during type 2 olarization of murine CD8(+) effector T cells is associated with CpG methylation of several regions of the Cd8a locus.

Human CD8a Molecule (CD8A) interaction partners

  1. Endometrioid endometrial carcinomas are capable of down-regulating CD8 expression by cytotoxic T lymphocytes.

  2. The PD-1 (show PDCD1 Proteins)/CD8 ratio may, therefore, be a useful prognostic marker for stage II/III CRC (show CALR Proteins). What is important for predicting the prognosis may be the PD-1 (show PDCD1 Proteins)/CD8 ratio rather than the absolute number of PD-1 (show PDCD1 Proteins)(+) tumor-infiltrating lymphocytes .

  3. We also observed a significant association between forkhead box protein 3 (show HSPB3 Proteins) ( p = 0.001) and the Neo-Bioscore, while only a marginal difference was observed with CD8+ expression ( p = 0.074). This study demonstrated that forkhead box protein 3 (show HSPB3 Proteins) expression has value as the only independent marker that predicts a good response to neoadjuvant chemotherapy and that it is related with a good prognosis according to the Neo-Biosc

  4. Human mesenchymal stromal cells enhance the immunomodulatory function of CD8(+)CD28 (show CD28 Proteins)(-) regulatory T cells.

  5. In localized colorectal cancer carriers, mRNA-based CD3Z (show CD247 Proteins)/CD8 profiling of tumor immune response may have stage, site and tissue-specific prognostic significance, along with ESR1 (show ESR1 Proteins) expression.

  6. Dendritic cells accumulate in the bone marrow of multiple myeloma patients and protect tumor plasma cells from CD8+ T-cell killing.

  7. Patients with the presence of CD8- and CD45RO-positive T cells in bone marrow demonstrated better survival of gastric cancer patients than those with the absence of these cells in bone marrow.

  8. CD58 (show CD58 Proteins)/CD2 (show CD2 Proteins) is the primary costimulatory pathway in human CD28 (show CD28 Proteins)-CD8+ T cells.

  9. We suggest that unique set of interactions between CEACAM5 (show CEACAM5 Proteins), CD1d (show CD1D Proteins), and CD8 render CD1d (show CD1D Proteins) more class I-like molecule, facilitating antigen presentation and activation of CD8(+)-suppressor regulatory T cells.

  10. More sCD8 circulating molecules were found in patients transfused with post-storage leucodepleted RBCs (show SSU1 Proteins) whose supernatants had large amounts of sHLA-I. sCD8 is a possible modulator of sHLA-I-mediated transfusion-related immunomodulation.

Pig (Porcine) CD8a Molecule (CD8A) interaction partners

  1. Findings indicate associations of differentiation 8 alpha (CD8A) variants with T lymphocyte subpopulations and suggest applications in porcine breeding programs.

CD8 (CD8A) Protein Profile

Protein Summary

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CD8 (CD8A)

  • CD8 antigen, alpha chain (Cd8a)
  • CD8 antigen, alpha polypeptide (cd8)
  • CD8 alpha (LOC100136450)
  • T-cell surface glycoprotein CD8 alpha chain-like (LOC100387674)
  • CD8 antigen, alpha polypeptide (cd8a)
  • CD8a molecule (CD8A)
  • CD8a molecule (Cd8a)
  • BB154331 protein
  • CD8 protein
  • Leu2 protein
  • LOC100136450 protein
  • Ly-2 protein
  • Ly-35 protein
  • Ly-B protein
  • Lyt-2 protein
  • MAL protein
  • p32 protein
  • RHACD8-4 protein
  • zgc:136643 protein

Protein level used designations for CD8a Molecule Proteins (CD8A)

CD8 alpha , CD8a molecule , T-cell surface glycoprotein CD8 alpha chain , CD8 antigen, alpha polypeptide , T-cell surface glycoprotein CD8 alpha chain-like , Lyt-2.1 lymphocyte differentiation antigen (AA at 100) , T-cell surface glycoprotein Lyt-2 , CD8 antigen, alpha polypeptide (p32) , Leu2 T-lymphocyte antigen , OKT8 T-cell antigen , T cell co-receptor , T-cell antigen Leu2 , T-lymphocyte differentiation antigen T8/Leu-2 , T8 T-cell antigen , CD8 antigen 32 kDa chain , CD8 antigen alpha-chain , CD8 antigen, alpha chain , CD8 antigen, alpha-chain , OX-8 membrane antigen , CD8 antigen alpha polypeptide , CD8 alpha chain , T-cell surface molecule , CD8 alpha molecule

100379570 Cavia porcellus
100125537 Oryzias latipes
100136450 Salmo salar
100387674 Callithrix jacchus
12525 Mus musculus
677754 Danio rerio
925 Homo sapiens
24930 Rattus norvegicus
396627 Sus scrofa
428800 Gallus gallus
403158 Gallus gallus
100126556 Meleagris gallopavo
493799 Felis catus
403157 Canis lupus familiaris
281060 Bos taurus
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