anti-Human CD80 antibody for Immunocytochemistry

Recommended CD80 Antibody (supplied by: Log in to see )

Antigen
CD80 Antibodies
  • CD8
  • Leu2
  • MAL
  • p32
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
  • CD80 molecule
  • CD8a molecule
  • CD80 antigen
  • Cd80 molecule
  • CD80
  • CD8A
  • Cd80
Reactivity
Human
447
282
47
11
10
7
6
3
2
2
1
1
Host
Mouse
403
115
102
91
41
19
Clonality
Monoclonal
Conjugate
This CD80 antibody is un-conjugated
76
74
53
26
20
18
15
14
13
12
10
10
8
8
8
8
7
7
7
5
5
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA
526
205
139
136
122
81
65
44
30
30
26
17
9
8
7
6
6
5
5
4
2
2
2
2
1
1
1
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Catalog No. ABIN969028
$ 393.80
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2869411 ELISA ICC IHC Mouse IgG1 Log in to see 2A2
1 ABIN4282672 ELISA ICC IF IHC Mouse IgG1 Log in to see 2A2
1 ABIN4282673 ICC IF IHC IHC (p) WB Mouse IgG2a Log in to see 2E5
1 ABIN4957050 ELISA FACS ICC IF Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957051 ELISA FACS ICC IF Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957052 ELISA FACS ICC IF Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957062 FACS ICC IF FITC Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957057 FACS ICC IF Alexa Fluor 647 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957064 FACS ICC IF DyLight 755 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957056 FACS ICC IF Alexa Fluor 488 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957055 FACS ICC IF Alexa Fluor 405 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957067 FACS ICC IF DyLight 550 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957069 FACS ICC IF DyLight 405 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957070 FACS ICC IF DyLight 405LS Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957068 FACS ICC IF DyLight 350 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957054 CyTOF ELISA FACS ICC IF Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957058 FACS ICC IF Alexa Fluor 700 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957061 FACS ICC IF DyLight 650 Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957060 ICC IF Biotin Mouse IgG1 kappa Log in to see C80-1608
1 ABIN4957063 FACS ICC IF DyLight 680 Mouse IgG1 kappa Log in to see C80-1608

General

Antigen CD80 Antibodies
Reactivity Human
(447), (282), (47), (11), (10), (7), (6), (3), (2), (2), (1), (1)
Host Mouse
(403), (115), (102), (91), (41), (19)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD80 antibody is un-conjugated
(76), (74), (53), (26), (20), (18), (15), (14), (13), (12), (10), (10), (8), (8), (8), (8), (7), (7), (7), (5), (5), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA
(526), (205), (139), (136), (122), (81), (65), (44), (30), (30), (26), (17), (9), (8), (7), (6), (6), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-CD80 Antibody

Target Details CD80 Application Details Handling ProductDetails: References for anti-CD80 antibody (ABIN969028) Images
Purification Ascites
Immunogen Purified recombinant fragment of CD80 expressed in E. Coli.
Clone 2A2
Isotype IgG1

Target Details CD80

Product Details anti-CD80 Antibody Application Details Handling ProductDetails: References for anti-CD80 antibody (ABIN969028) Images back to top
Antigen
Alternative Name CD80 (CD80 Antibody Abstract)
Background The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin, Estrogen stimulates osteoprotegerin production.
Molecular Weight 55 kDa
Gene ID 941
HGNC 941
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process

Application Details

Product Details anti-CD80 Antibody Target Details CD80 Handling ProductDetails: References for anti-CD80 antibody (ABIN969028) Images back to top
Application Notes ELISA: 1:10000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
Restrictions For Research Use only

Handling

Product Details anti-CD80 Antibody Target Details CD80 Application Details ProductDetails: References for anti-CD80 antibody (ABIN969028) Images back to top
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage

ProductDetails: References for anti-CD80 antibody (ABIN969028)

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling Images back to top
Product cited in:

Wang, Liu, Wu, Zhu, Wang, Xu: "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." in: Transplantation proceedings, Vol. 40, Issue 8, pp. 2729-33, 2008

Stephan, Ponomarev, Brentjens, Chang, Dobrenkov, Heller, Sadelain: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, 2007

Images

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling ProductDetails: References for anti-CD80 antibody (ABIN969028) back to top
Supplier Images
Immunocytochemistry (ICC) image for anti-CD80 (CD80) antibody (ABIN969028) Figure 1: Confocal immunofluorescence analysis of BCBL-1 cells using anti-CD80 monocl...
Immunohistochemistry (IHC) image for anti-CD80 (CD80) antibody (ABIN969028) Figure 2: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues usin...