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anti-Human CD80 antibody for Immunofluorescence

Recommended CD80 Antibody (supplied by: Log in to see )

Antigen
CD80 Antibodies
  • CD8
  • Leu2
  • MAL
  • p32
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
  • CD80 molecule
  • CD8a molecule
  • CD80 antigen
  • Cd80 molecule
  • CD80
  • CD8A
  • Cd80
Reactivity
Human
430
268
46
10
10
7
7
3
2
2
Host
Mouse
388
111
97
84
41
18
Clonality
Monoclonal
Conjugate
This CD80 antibody is un-conjugated
74
71
49
24
20
18
14
14
12
11
10
10
8
8
8
8
7
5
5
5
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
505
198
132
124
113
68
61
44
31
28
26
9
8
7
7
6
6
6
5
5
4
2
2
2
2
1
1
1
1
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Catalog No. ABIN1106582
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.320827 ABIN2452902 FACS IF WB Mouse IgG1 Log in to see 1E9
11.320827 ABIN2452896 IF WB Mouse IgG1 Log in to see 7E4
11.320827 ABIN2452897 IF WB Mouse IgG1 Log in to see 6H7
11.320827 ABIN2452893 IF WB Mouse IgG1 Log in to see 9H1
11.320827 ABIN2452894 IF WB Mouse IgG1 Log in to see 7H7
11.320827 ABIN4282673 ICC IF IHC IHC (p) WB Mouse IgG2a Log in to see 2E5
11.320827 ABIN4282672 ELISA ICC IF IHC Mouse IgG1 Log in to see 2A2
11.320827 ABIN931341 IF ELISA Mouse IgG1 Log in to see 2A2
1 ABIN2659554 IF PE-Cy7 Mouse IgG1 kappa Log in to see 2D10 8
1 ABIN1497366 IF WB Mouse IgG1 Log in to see 7E4
1 ABIN1497367 IF WB Mouse IgG1 Log in to see 6H7
1 ABIN1497368 IF WB Mouse IgG1 Log in to see 9H1
1 ABIN1497369 IF WB Mouse IgG1 Log in to see 7H7
1 ABIN1497370 IF WB Mouse IgG1 Log in to see 10D8
1 ABIN1497365 IF IHC (p) WB Mouse IgG2a Log in to see 2E5
1 ABIN2452900 IF IHC WB Mouse IgG2a Log in to see 2E5
1 ABIN2452895 IF WB Mouse IgG1 Log in to see 10D8
1 ABIN2452899 IF IHC WB Mouse IgG2a Log in to see 2B11
1 ABIN574035 IF IHC (p) ELISA Mouse IgG1 Log in to see 2A2
1 ABIN2470886 IF IHC ELISA Mouse IgG1 Log in to see 2A2

Top referenced anti-CD80 antibody for Immunofluorescence

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Application / Reactivity Human
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ELISA 107 Antibodies
ELISA (Capture) 2 Antibodies
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Flow Cytometry (FACS) 262 Antibodies
Functional Studies (Func) 9 Antibodies
Immunocytochemistry (ICC) 22 Antibodies
Immunofluorescence (IF) 56 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 5 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies
Immunohistochemistry (IHC) 57 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 44 Antibodies
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General

Antigen CD80 Antibodies
Reactivity Human
(430), (268), (46), (10), (10), (7), (7), (3), (2), (2)
Host Mouse
(388), (111), (97), (84), (41), (18)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD80 antibody is un-conjugated
(74), (71), (49), (24), (20), (18), (14), (14), (12), (11), (10), (10), (8), (8), (8), (8), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(505), (198), (132), (124), (113), (68), (61), (44), (31), (28), (26), (9), (8), (7), (7), (6), (6), (6), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-CD80 Antibody

Target Details CD80 Application Details Handling References for anti-CD80 Antibody (ABIN1106582) Images
Specificity Recognizes CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Clone 2A2
Isotype IgG1

Target Details CD80

Product Details anti-CD80 Antibody Application Details Handling References for anti-CD80 Antibody (ABIN1106582) Images back to top
Antigen
Alternative Name CD80 (CD80 Antibody Abstract)
Background The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin, Estrogen stimulates osteoprotegerin production.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
Molecular Weight 55 kDa
Gene ID 941
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Immune Effector Process

Application Details

Product Details anti-CD80 Antibody Target Details CD80 Handling References for anti-CD80 Antibody (ABIN1106582) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD80 Antibody Target Details CD80 Application Details References for anti-CD80 Antibody (ABIN1106582) Images back to top
Format Liquid

References for anti-CD80 Antibody (ABIN1106582)

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling Images back to top
Background publications

Wang, Liu, Wu, Zhu, Wang, Xu: "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." in: Transplantation proceedings, Vol. 40, Issue 8, pp. 2729-33, 2008

Stephan, Ponomarev, Brentjens, Chang, Dobrenkov, Heller, Sadelain: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, 2007

Images

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling References for anti-CD80 Antibody (ABIN1106582) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-CD80 antibody (CD80) (ABIN1106582) anti-CD80 (CD80) antibody
Immunofluorescence (IF) image for anti-CD80 antibody (CD80) (ABIN1106582) anti-CD80 (CD80) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-CD80 antibody (CD80) (ABIN1106582) anti-CD80 (CD80) antibody (Image 3)