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anti-Human CD80 antibody for Immunohistochemistry

Recommended CD80 Antibody (supplied by: Log in to see )

Antigen
CD80 Antibodies
  • CD8
  • Leu2
  • MAL
  • p32
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
  • CD80 molecule
  • CD8a molecule
  • CD80 antigen
  • Cd80 molecule
  • CD80
  • CD8A
  • Cd80
Reactivity
Human
430
267
48
10
8
8
3
2
2
2
Host
Mouse
397
113
101
71
41
19
Clonality
Monoclonal
Conjugate
This CD80 antibody is un-conjugated
79
77
50
25
18
16
13
13
12
11
8
8
7
7
7
7
6
5
5
5
5
4
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA
514
194
125
117
111
67
57
41
35
28
22
8
7
7
7
7
7
5
5
5
4
2
2
2
2
1
1
1
1
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Catalog No. ABIN969028
$ 393.80
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
8.500999 ABIN4900275 ELISA (Capture) FACS IHC Neut Mouse IgG1 AA 35-242 Log in to see 37711 3
8.500999 ABIN4900274 ELISA (Capture) FACS IHC Neut Mouse IgG1 AA 35-242 Log in to see 37711 3
8.500999 ABIN2453864 IHC WB Mouse IgG2a Log in to see 3F1
8.500999 ABIN2452900 IF IHC WB Mouse IgG2a Log in to see 2E5
8.500999 ABIN2452901 IHC WB Mouse IgG2b Log in to see 2H1
8.500999 ABIN2452899 IF IHC WB Mouse IgG2a Log in to see 2B11
8.500999 ABIN2470886 IF IHC ELISA Mouse IgG1 Log in to see 2A2
8.500999 ABIN4282672 ELISA ICC IF IHC Mouse IgG1 Log in to see 2A2
8.500999 ABIN4255260 IHC Rabbit IgG Log in to see Polyclonal
8.500999 ABIN2432709 IHC ELISA Rabbit IgG Log in to see Polyclonal
8.500999 ABIN2434330 IHC ELISA Rabbit IgG Log in to see Polyclonal
8.500999 ABIN1845393 ICC IF IHC ELISA Mouse IgG1 Log in to see
1 ABIN4282682 FACS IHC IHC (p) WB Mouse IgG2b kappa Log in to see 62N3G8 1
1 ABIN958073 IHC WB Goat IgG Log in to see Polyclonal
1 ABIN2869411 ELISA ICC IHC Mouse IgG1 Log in to see 2A2
1 ABIN4282673 ICC IF IHC IHC (p) WB Mouse IgG2a Log in to see 2E5
1 ABIN4282683 FACS IHC IHC (p) WB Alexa Fluor 700 Mouse IgG2b kappa Log in to see 62N3G8
1 ABIN204040 FACS IHC Biotin Mouse IgG1 Log in to see
1 ABIN4903203 FACS IF IHC WB Mouse IgG Log in to see
1 ABIN2228952 IHC ELISA Mouse IgG1 Log in to see 13B143

Top referenced anti-CD80 antibody for Immunohistochemistry

Similar anti-CD80 Antibodies

Application / Reactivity Human
Blocking Peptide (BP) 2 Antibodies
Cytometry by Time of Flight (CyTOF) 4 Antibodies
ELISA 106 Antibodies
ELISA (Capture) 2 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies
Flow Cytometry (FACS) 261 Antibodies
Functional Studies (Func) 9 Antibodies
Immunocytochemistry (ICC) 27 Antibodies
Immunofluorescence (IF) 61 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 57 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 42 Antibodies
Immunoprecipitation (IP) 54 Antibodies
Intracellular Flow Cytometry (ICFC) 3 Antibodies
Luminex Assay (LMNX) 5 Antibodies
Neutralization (Neut) 5 Antibodies

General

Antigen CD80 Antibodies
Reactivity Human
(430), (267), (48), (10), (8), (8), (3), (2), (2), (2)
Host Mouse
(397), (113), (101), (71), (41), (19)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD80 antibody is un-conjugated
(79), (77), (50), (25), (18), (16), (13), (13), (12), (11), (8), (8), (7), (7), (7), (7), (6), (5), (5), (5), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA
(514), (194), (125), (117), (111), (67), (57), (41), (35), (28), (22), (8), (7), (7), (7), (7), (7), (5), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-CD80 Antibody

Target Details CD80 Application Details Handling References for anti-CD80 Antibody (ABIN969028) Images
Purification Ascites
Immunogen Purified recombinant fragment of CD80 expressed in E. coli.
Clone 2A2
Isotype IgG1

Target Details CD80

Product Details anti-CD80 Antibody Application Details Handling References for anti-CD80 Antibody (ABIN969028) Images back to top
Antigen
Alternative Name CD80 (CD80 Antibody Abstract)
Background The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin, Estrogen stimulates osteoprotegerin production.
Molecular Weight 55 kDa
Gene ID 941
HGNC 941
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-CD80 Antibody Target Details CD80 Handling References for anti-CD80 Antibody (ABIN969028) Images back to top
Application Notes Recommended Dilution:
ELISA: 1/10000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only

Handling

Product Details anti-CD80 Antibody Target Details CD80 Application Details References for anti-CD80 Antibody (ABIN969028) Images back to top
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.

References for anti-CD80 Antibody (ABIN969028)

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling Images back to top
Product cited in:

Wang, Liu, Wu, Zhu, Wang, Xu: "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." in: Transplantation proceedings, Vol. 40, Issue 8, pp. 2729-33, 2008

Stephan, Ponomarev, Brentjens, Chang, Dobrenkov, Heller, Sadelain: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, 2007

Images

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling References for anti-CD80 Antibody (ABIN969028) back to top
Supplier Images
Immunocytochemistry (ICC) image for anti-CD80 antibody (CD80) (ABIN969028) Figure 1: Confocal immunofluorescence analysis of BCBL-1 cells using anti-CD80 monocl...
Immunohistochemistry (IHC) image for anti-CD80 antibody (CD80) (ABIN969028) Figure 2: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues usin...