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anti-Human CD80 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended CD80 Antibody (supplied by: Log in to see )

Antigen
CD80 Antibodies
  • B7
  • B7-1
  • B7.1
  • B71
  • BB1
  • CD8
  • Cd28l
  • CD28LG
  • CD28LG1
  • LAB7
  • Leu2
  • Ly-53
  • Ly53
  • MAL
  • MIC17
  • p32
  • TSA1
Reactivity
Human
313
222
50
17
10
9
8
3
2
2
1
Host
Mouse
287
109
98
59
16
14
Clonality
Monoclonal
Conjugate
This CD80 antibody is un-conjugated
67
65
41
26
11
10
8
7
5
5
5
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
366
173
114
106
48
43
25
22
22
17
14
7
7
7
6
5
5
4
3
2
2
2
1
1
1
1
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Catalog No. ABIN1106582
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00089488085 ABIN1497365 IF IHC (p) WB Mouse IgG2a Log in to see 2E5
0.00089488085 ABIN1497372 IHC (p) WB Mouse IgG2a Log in to see 3F1
0.00089488085 ABIN1497371 IHC (p) WB Mouse IgG2b Log in to see 2H1
0.00089488085 ABIN574035 IF IHC (p) ELISA Mouse IgG1 Log in to see 2A2
0.00089488085 ABIN1997285 IHC (p) ELISA Rabbit IgG AA 1-242 Log in to see Polyclonal
0.00089488085 ABIN687144 IHC (p) WB Biotin Rabbit IgG AA 90-140 Log in to see Polyclonal
0.00089488085 ABIN687151 IHC (p) WB HRP Rabbit IgG AA 90-140 Log in to see Polyclonal
0.00089488085 ABIN687142 IF (p) IHC (p) WB Rabbit IgG AA 90-140 Log in to see Polyclonal
0.00089488085 ABIN2770749 IHC (p) IHC ELISA Mouse IgG1 Log in to see 2A2
0.00089488085 ABIN2718322 IHC (p) Mouse IgG2b Log in to see UMAB65
0.00089488085 ABIN2718323 IHC (p) Mouse IgG2b Log in to see UMAB65
0.00089488085 ABIN2681733 IHC (p) ELISA WB Rabbit Log in to see Polyclonal
0.00089488085 ABIN2681731 IHC (p) ELISA Rabbit Log in to see Polyclonal

Top referenced anti-CD80 antibody for Immunohistochemistry (Paraffin-embedded Sections)

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General

Antigen CD80 Antibodies
Reactivity Human
(313), (222), (50), (17), (10), (9), (8), (3), (2), (2), (1)
Host Mouse
(287), (109), (98), (59), (16), (14)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD80 antibody is un-conjugated
(67), (65), (41), (26), (11), (10), (8), (7), (5), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(366), (173), (114), (106), (48), (43), (25), (22), (22), (17), (14), (7), (7), (7), (6), (5), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-CD80 Antibody

Target Details CD80 Application Details Handling References for anti-CD80 Antibody (ABIN1106582) Images
Specificity Recognizes CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Clone 2A2
Isotype IgG1

Target Details CD80

Product Details anti-CD80 Antibody Application Details Handling References for anti-CD80 Antibody (ABIN1106582) Images back to top
Antigen
Alternative Name CD80 (CD80 Antibody Abstract)
Background The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin, Estrogen stimulates osteoprotegerin production.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
Molecular Weight 55 kDa
Gene ID 941
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-CD80 Antibody Target Details CD80 Handling References for anti-CD80 Antibody (ABIN1106582) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD80 Antibody Target Details CD80 Application Details References for anti-CD80 Antibody (ABIN1106582) Images back to top
Format Liquid

References for anti-CD80 Antibody (ABIN1106582)

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling Images back to top
Background publications

Wang, Liu, Wu, Zhu, Wang, Xu: "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." in: Transplantation proceedings, Vol. 40, Issue 8, pp. 2729-33, 2008

Stephan, Ponomarev, Brentjens, Chang, Dobrenkov, Heller, Sadelain: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, 2007

Images

Product Details anti-CD80 Antibody Target Details CD80 Application Details Handling References for anti-CD80 Antibody (ABIN1106582) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-CD80 antibody (CD80) (ABIN1106582) anti-CD80 (CD80) antibody
Immunofluorescence (IF) image for anti-CD80 antibody (CD80) (ABIN1106582) anti-CD80 (CD80) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-CD80 antibody (CD80) (ABIN1106582) anti-CD80 (CD80) antibody (Image 3)