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|Epitope||AA 1-143 Alternatives|
|Conjugate||This CD83 antibody is un-conjugated Alternatives|
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Product Details anti-CD83 AntibodyTarget Details CD83 Application Details Handling Images
|Characteristics||Produced in rabbits immunized with purified, recombinant Cynomolgus CD83 (ABIN2009978 F6WX37, Met1-Ala143,. Total IgG was purified by Protein A affinity chromatography.|
|Purification||purified by Protein A affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Cynomolgus CD83 protein (ABIN2009978)|
Target Details CD83Product Details anti-CD83 Antibody Application Details Handling Images back to top
|Alternative Name||CD83 (CD83 Antibody Abstract)|
|Background||CD83 antigen, also known as B-cell activation protein, Cell surface protein HB15 and CD83, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin- like) domain. CD83 is a a conserved member of the immunoglobulin superfamily. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. CD83 is a fascinating cell surface molecule with a unique pattern of expression that has multiple confirmed functions in regulating immune system development and function. CD83 represents an intriguing target for immunotherapy due to its preferential expression on mature dendritic cells (DCs), the most efficient of antigen presenting cells. On the protein level, two different isoforms of CD83 exist: a membrane-bound and a soluble form. The isoforms are generated by different subsets of cells, including DCs, T-cells and B-cells, and also differ in their biological function. While the membrane-bound CD83 is of immune stimulatory capacity, activates T-cells and is important for the generation of thymocytes, the soluble CD83 has the opposite effect and has an immune inhibitory capacity. Due to its immune inhibitory function. CD83 may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. CD83 has great potential for treatment of autoimmune diseases, for organ transplantations, and for immunotherapy, just to name a few examples. Moreover, some viruses prevent recognition by the host's immune system by specifically targeting CD83 surface expression.|
|Research Area||Immunology, CD Antigens, Adaptive Immunity, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-CD83 Antibody Target Details CD83 Handling Images back to top
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Cynomolgus CD83. The detection limit for Cynomolgus CD83 is approximately ≤ 0.039 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD83 Antibody Target Details CD83 Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|