|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||361 Antibodies||162 Antibodies||158 Antibodies|
|Proximity Ligation Assay (PLA)||3 Antibodies||1 Antibodies|
|Intracellular Staining (ICS)||3 Antibodies||3 Antibodies||3 Antibodies|
|Immunoprecipitation (IP)||38 Antibodies||21 Antibodies||19 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||61 Antibodies||29 Antibodies||29 Antibodies|
|Immunohistochemistry (IHC)||218 Antibodies||113 Antibodies||117 Antibodies|
|Antigen||CAMP Responsive Element Binding Protein 1 (CREB1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This CREB1 antibody is un-conjugated Alternatives|
Dot Blot (DB), Western Blotting (WB)
|6 references available|
|Supplier||Log in to see|
Product Details anti-CREB1 AntibodyTarget Details CREB1 Application Details Handling References for anti-CREB1 Antibody (ABIN265094) Images
|Specificity||This antibody reacts to CREB (pSer133).|
|Immunogen||Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Ser133 of CREB.|
Target Details CREB1Product Details anti-CREB1 Antibody Application Details Handling References for anti-CREB1 Antibody (ABIN265094) Images back to top
|Alternative Name||CREB1 (CREB1 Antibody Abstract)|
|Background||It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus. The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulusinduced transcription factors. This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory. A variety of protein kinases including protein kinase A (PKA), mitogenactivated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 is required for CREB mediated transcription.Synonyms: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1|
|Pathways||TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-CREB1 Antibody Target Details CREB1 Handling References for anti-CREB1 Antibody (ABIN265094) Images back to top
Suitable for use in Western Blot and Dot Blot (1/1000). Positive Control/Tissue Expression: Rat brain lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-CREB1 Antibody Target Details CREB1 Application Details References for anti-CREB1 Antibody (ABIN265094) Images back to top
|Buffer||HEPES ( pH 7.5) solution containing 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Store the antibody (in aliquots) at -20 °C to -70 °C.|
References for anti-CREB1 Antibody (ABIN265094)Product Details anti-CREB1 Antibody Target Details CREB1 Application Details Handling Images back to top
Johannessen, Delghandi, Moens: "What turns CREB on?" in: Cellular signalling, Vol. 16, Issue 11, pp. 1211-27, 2004 (PubMed).
Shaywitz, Greenberg: "CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals." in: Annual review of biochemistry, Vol. 68, Issue 2, pp. 821-61, 2000 (PubMed).
Abel, Kandel: "Positive and negative regulatory mechanisms that mediate long-term memory storage." in: Brain research. Brain research reviews, Vol. 26, Issue 2-3, pp. 360-78, 1998 (PubMed).
Silva, Kogan, Frankland et al.: "CREB and memory." in: Annual review of neuroscience, Vol. 21, pp. 127-48, 1998 (PubMed).
Montminy: "Transcriptional regulation by cyclic AMP." in: Annual review of biochemistry, Vol. 66, pp. 807-22, 1997 (PubMed).
Bird: "The essentials of DNA methylation." in: Cell, Vol. 70, Issue 1, pp. 5-8, 1992 (PubMed).
ImagesProduct Details anti-CREB1 Antibody Target Details CREB1 Application Details Handling References for anti-CREB1 Antibody (ABIN265094) back to top