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anti-Human CrkL antibody for Western Blotting

Recommended CrkL Antibody (supplied by: Log in to see )

Antigen
V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL) Antibodies
  • 1110025F07Rik
  • AA589403
  • AI325100
  • CRKL
  • Crkol
  • wu:fa55g05
  • wu:fj60e01
  • zgc:63469
Epitope
pTyr207
39
18
16
15
13
13
12
12
9
7
5
3
3
3
2
2
2
2
1
1
1
1
Reactivity
Human
138
80
57
2
1
1
Host
Mouse
106
27
24
1
Clonality
Monoclonal
Conjugate
This CrkL antibody is un-conjugated
7
7
7
6
5
5
3
3
2
2
2
2
2
2
1
Application
Western Blotting (WB)
128
72
30
21
18
17
10
3
3
3
2
2
2
1
Supplier
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Catalog No. ABIN967605
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.12935057 ABIN969064 FACS ELISA WB Mouse IgG1 Log in to see 5-00E-12 1
0.12935057 ABIN268650 IHC (p) IHC ELISA WB Goat IgG C-Term Log in to see Polyclonal 1
0.12935057 ABIN1531223 IF IHC ELISA WB Rabbit IgG pTyr207 Log in to see Polyclonal
0.12935057 ABIN2779341 WB Rabbit Middle Region Log in to see Polyclonal
0.12935057 ABIN657468 WB Rabbit Ig AA 50-79, N-Term Log in to see Polyclonal
0.12935057 ABIN514606 IF PLA RNAi ELISA WB Mouse IgG2b kappa AA 204-303, partial Log in to see 4B5 2
0.12935057 ABIN1532241 IF IHC ELISA WB Rabbit IgG Log in to see Polyclonal
0.12935057 ABIN3043046 WB Rabbit IgG AA 286-303, C-Term Log in to see Polyclonal
0.12935057 ABIN514605 IF PLA WB Rabbit AA 1-303, full length Log in to see Polyclonal 1
0.12935057 ABIN393757 WB Mouse IgG2b kappa pTry207 Log in to see 4B5
0.12935057 ABIN498177 IF IHC (p) WB Rabbit Log in to see Polyclonal
0.12935057 ABIN2163973 IF IHC ELISA WB Rabbit IgG Tyr207 Log in to see Polyclonal
0.12935057 ABIN2463653 ELISA WB Rabbit Log in to see Polyclonal
0.12935057 ABIN2465201 ELISA WB Goat C-Term Log in to see Polyclonal
0.12935057 ABIN2160326 WB Rabbit Ig Fraction N-Term Log in to see Polyclonal
0.12935057 ABIN514603 IF WB Mouse AA 1-303, full length Log in to see Polyclonal
0.12935057 ABIN1106836 EIA WB Mouse IgG1 Log in to see 5-00E-012
0.12935057 ABIN926865 WB Rabbit Middle Region, pTry207 Log in to see Polyclonal
0.12935057 ABIN514604 IF WB Mouse AA 1-303, full length Log in to see Polyclonal
0.12935057 ABIN2432887 IHC ELISA WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-CrkL antibody for Western Blotting

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General

Antigen V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL) Antibodies
Epitope pTyr207
(39), (18), (16), (15), (13), (13), (12), (12), (9), (7), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity Human
(138), (80), (57), (2), (1), (1)
Host Mouse
(106), (27), (24), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CrkL antibody is un-conjugated
(7), (7), (7), (6), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (1)
Application Western Blotting (WB)
(128), (72), (30), (21), (18), (17), (10), (3), (3), (3), (2), (2), (2), (1)
Pubmed 3 references available
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Product Details anti-CrkL Antibody

Target Details CrkL Application Details Handling References for anti-CrkL Antibody (ABIN967605) Images
Brand BD Pharmingen™
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Phosphorylated Human, Mouse, and Rat CrkL Peptide
Clone K30-391-11-30
Isotype IgG2a, kappa

Target Details CrkL

Product Details anti-CrkL Antibody Application Details Handling References for anti-CrkL Antibody (ABIN967605) Images back to top
Antigen
Alternative Name CrkL (CRKL Antibody Abstract)
Background Crk-Like (CrkL) is an adaptor protein that is preferentially expressed in hematopoietic cells and is encoded by a gene that is homologous to the viral oncogene v-crk (chicken tumor virus no. 10 regulator of kinase). Its SH2 and SH3 domains bind to a variety of effector proteins, such as paxillin, p130Cas, c-Cbl, c-Abl, and C3G. These interactions are involved in the regulation of cellular migration, adhesion, and transformation. Tyrosine 207 (Y207) of CrkL is phosphorylated in activated hematopoietic cells and in chronic myelogenous leukemia. This site may be a negative regulator of protein complex formation and biological activity. The K30-391.11.30 monoclonal antibody recognizes the phosphorylated Y207 of human CrkL.
Molecular Weight 39 kDa
Research Area Cancer, Transcription Factors
Pathways TCR Signaling, Interferon-gamma Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-CrkL Antibody Target Details CrkL Handling References for anti-CrkL Antibody (ABIN967605) Images back to top
Comment

Related Products: ABIN967389, ABIN968587

Restrictions For Research Use only

Handling

Product Details anti-CrkL Antibody Target Details CrkL Application Details References for anti-CrkL Antibody (ABIN967605) Images back to top
Format Liquid
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.

References for anti-CrkL Antibody (ABIN967605)

Product Details anti-CrkL Antibody Target Details CrkL Application Details Handling Images back to top
Product cited in:

Feller: "Crk family adaptors-signalling complex formation and biological roles." in: Oncogene, Vol. 20, Issue 44, pp. 6348-71, 2001

Arai, Nosaka, Kohsaka, Miyasaka, Miura: "CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G." in: Blood, Vol. 93, Issue 11, pp. 3713-22, 1999

Senechal, Heaney, Druker, Sawyers: "Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells." in: Molecular and cellular biology, Vol. 18, Issue 9, pp. 5082-90, 1998

Images

Product Details anti-CrkL Antibody Target Details CrkL Application Details Handling References for anti-CrkL Antibody (ABIN967605) back to top
Supplier Images
Western Blotting (WB) image for anti-CrkL antibody (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like) (pTyr207) (ABIN967605) Western blot analysis of CrkL (pY207) in human chronic myelogenous leukemia. Lysates ...