Browse our Filamin A Proteins (FLNA)

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Filamin A, alpha Proteins (FLNA)
On are 3 Filamin A, alpha (FLNA) Proteins from 3 different suppliers available. Additionally we are shipping Filamin A Antibodies (154) and Filamin A Kits (32) and many more products for this protein. A total of 195 Filamin A products are currently listed.
ABP-280, ABPX, cb967, CG3937, Cher, CSBS, CVD1, Dilp2, Dmel\\CG3937, F730004A14Rik, fb98b06, Fil, filamin-1, FLN, FLN-A, Fln1, flna, FMD, joy, MGC147094, MNS, NHBP, OPD, OPD1, OPD2, RGD1560614, sko, wu:fb98b06, wu:fd09g03, wu:fd18g06, wu:fd49a06, XLVD, XMVD
list all proteins Gene Name GeneID UniProt
FLNA 2316 P21333
Rat FLNA FLNA 293860  
Mouse FLNA FLNA 192176 Q8BTM8

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Filamin A Proteins (FLNA) by Origin

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Top referenced Filamin A Proteins

  1. Human Filamin A Protein expressed in HEK-293 Cells - ABIN2721188 : Henkels, Mallets, Dennis, Gomez-Cambronero: S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 (PubMed)

More Proteins for Filamin A Interaction Partners

Zebrafish Filamin A, alpha (FLNA) interaction partners

  1. Knockdown of filamin A or vimentin (show VIM Proteins) in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells.

Fruit Fly (Drosophila melanogaster) Filamin A, alpha (FLNA) interaction partners

  1. Here we show using Drosophila indirect flight mus (show KPTN Proteins)cle that t (show FLNC Proteins)he filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc. We identify the filamin domains required for interaction with the (show TTN Proteins) titin ortholog Sallimus, and we demonstrate a genetic interaction of filamin with titin and actin.

  2. study identifies Cher as a new target of JNK (show MAPK8 Proteins) signaling that links cytoskeleton dynamics to tumor progression.

  3. Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells.

  4. Filamin is required for ovarian follicle cell motility during oogenesis.

Human Filamin A, alpha (FLNA) interaction partners

  1. These results provide new insights into the regulation of SK2 channel trafficking by the cytoskeletal proteins FLNA and alpha-actinin2, involving distinct recycling pathways

  2. Respiratory failure secondary to progressive obstructive lung disease during infancy may be the presenting phenotype of FLNA-associated periventricular nodular heterotopia.

  3. The actin regulator FLNA interacts with the endoplasmic reticulum stress kinase PERK and this interaction is required for the efficient formation of ER-plasma membrane contact sites.

  4. CCR2B (show CCR2 Proteins) and beta2AR (show ADRB2 Proteins) signals to FLNa to stimulate its endocytosis and recycling to the plasma membrane.

  5. In humans, mutations in the actin-binding protein (show KPTN Proteins) Filamin-C (show FLNC Proteins) result in myopathies, but the underlying molecular function is not well understood. Here we show using Drosophila indirect flight muscle that the filamin ortholog Cheerio in conjunction with the giant elastic protein titin (show TTN Proteins) plays a crucial role in keeping thin filaments stably anchored at the Z-disc

  6. Case Report: Reduced binding of mutant FLNa to beta3 and the facilitated recruitment of talin by beta3 on platelet stimulation, explaining the increased alphaIIbbeta3 activation and the ensuing gain-of-platelet functions.

  7. results reveal an unusual structural and thermodynamic basis for the P2204L-induced dysfunction of filamin and frontometaphyseal dysplasia disease.

  8. Mechanistic analysis revealed that FLNA suppresses pol III gene transcription by confining the recruitment of the RNA pol III transcription machinery at the promoters of the genes that are sensitive to the alteration of FLNA expression.

  9. FlnA more strongly binds RhoA (show RHOA Proteins), although both filamins overlap with RhoA (show RHOA Proteins) expression in the cell cytoplasm. FlnA promotes RhoA (show RHOA Proteins) activation whereas FlnB (show FLNB Proteins) indirectly inhibits this pathway. Moreover, FlnA loss leads to diminished expression of b1-integrin, whereas FlnB (show FLNB Proteins) loss promotes integrin expression

  10. FLNA can function as a modulator of chemosensitivity to docetaxel in triple-negative breast cancer (TNBC) cells through regulation of the MAPK/ERK (show MAPK1 Proteins) pathway both in vitro and in vivo. FLNA may serve as a novel therapeutic target for improvement of chemotherapy efficacy in TNBC.

Pig (Porcine) Filamin A, alpha (FLNA) interaction partners

  1. filamin reduces ENaC (show SCNN1A Proteins) channel function through direct interaction on the cell surface

Mouse (Murine) Filamin A, alpha (FLNA) interaction partners

  1. FlnA binding to PACSIN2 (show PACSIN2 Proteins) F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

  2. FlnA is a critical upstream element of the signaling cascade underlying the myogenic tone.

  3. Bones lacking filamin A are protected from estrogen-mediated post-menopausal osteoporosis

  4. findings suggest a model in which filamin A local translation following axon injury controls localized HDAC5 (show HDAC5 Proteins) activity to promote axon regeneration.

  5. Deletion of filamin A in endothelial cells aggravated myocardial infarction-induced left ventricle dysfunction and cardiac failure as a result of defective endothelial response

  6. A new signaling set, phosphatidic acid-S6K1-FLNA-actin, sheds light into the morphogenic pathway of cytoskeletal structures that are crucial for adhesion and cell locomotion during inflammation and metastasis.

  7. Filamin-A is associated with neutrophil uropod retraction.

  8. Analysis of editing in the filamin A encoding mRNA shows very high editing levels outside the nervous system; further shows FLNA editing is mainly achieved by ADAR2 (show ADARB1 Proteins) but that in some cases ADAR1 (show ADAR Proteins) can efficiently compensate for ADAR2 (show ADARB1 Proteins).

  9. Filamin a, b-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeleton.

  10. a major function of FLNa in modulating ion channel abundance and membrane trafficking in neurons, thereby shaping their biophysical properties and function.

Filamin A (FLNA) Protein Profile

Protein Summary

The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Filamin A (FLNA)

  • filamin A, alpha (actin binding protein 280) (flna)
  • filamin A, alpha (FLNA)
  • filamin B, like (flnbl)
  • filamin A, alpha (flna)
  • cheerio (cher)
  • filamin A, alpha (Flna)
  • filamin, alpha (Flna)
  • ABP-280 protein
  • ABPX protein
  • cb967 protein
  • CG3937 protein
  • Cher protein
  • CSBS protein
  • CVD1 protein
  • Dilp2 protein
  • Dmel\\CG3937 protein
  • F730004A14Rik protein
  • fb98b06 protein
  • Fil protein
  • filamin-1 protein
  • FLN protein
  • FLN-A protein
  • Fln1 protein
  • flna protein
  • FMD protein
  • joy protein
  • MGC147094 protein
  • MNS protein
  • NHBP protein
  • OPD protein
  • OPD1 protein
  • OPD2 protein
  • RGD1560614 protein
  • sko protein
  • wu:fb98b06 protein
  • wu:fd09g03 protein
  • wu:fd18g06 protein
  • wu:fd49a06 protein
  • XLVD protein
  • XMVD protein

Protein level used designations for Filamin A, alpha Proteins (FLNA)

fd09g03 , filamin A, alpha (actin binding protein 280) , filamin B, like , filamin A, alpha , filamin-A , CG3937-PA , CG3937-PB , CG3937-PF , CG3937-PG , CG3937-PH , CG3937-PI , CG3937-PK , CG3937-PL , CG3937-PM , CG3937-PN , Filamin-1 , Filamin-A , cher-PA , cher-PB , cher-PF , cher-PG , cher-PH , cher-PI , cher-PK , cher-PL , cher-PM , cher-PN , filamin , filamin B , filamin isoform B , filamin-240 , shi kong , actin binding protein 280 , alpha-filamin , endothelial actin-binding protein , filamin-1 , non-muscle filamin , Endothelial actin-binding protein 280) , filamin, alpha , 450 kDa protein , FLN-A , GENA 379 , actin-binding protein 280 , dilated pupils 2 , filamin A

562529 Danio rerio
699524 Macaca mulatta
569979 Danio rerio
587317 Strongylocentrotus purpuratus
779840 Xenopus (Silurana) tropicalis
100137263 Papio anubis
42066 Drosophila melanogaster
100380643 Salmo salar
2316 Homo sapiens
293860 Rattus norvegicus
481084 Canis lupus familiaris
733585 Sus scrofa
281165 Bos taurus
100328754 Oryctolagus cuniculus
100725162 Cavia porcellus
395261 Gallus gallus
101120390 Ovis aries
192176 Mus musculus
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