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Browse our anti-FYB (FYB) Antibodies

Full name:
anti-FYN-Binding Protein Antibodies (FYB)
On www.antibodies-online.com are 77 FYN-Binding Protein (FYB) Antibodies from 15 different suppliers available. Additionally we are shipping FYB Proteins (4) and FYB Kits (2) and many more products for this protein. A total of 94 FYB products are currently listed.
Synonyms:
ADAP, B630013F22Rik, fyb, FYB-120/130, p120/130, p120/p130, PRO0823, RGD1563421, SLAP-130, Slap130
list all antibodies Gene Name GeneID UniProt
FYB 2533 O15117
FYB 23880 O35601
FYB 499537  

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Most Popular Reactivities for anti-FYB (FYB) Antibodies

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anti-Human FYB Antibodies:

anti-Mouse (Murine) FYB Antibodies:

anti-Rat (Rattus) FYB Antibodies:

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Top referenced anti-FYB Antibodies

  1. Human Polyclonal FYB Primary Antibody for ICC, ELISA - ABIN1001738 : Rawlings, Sommer, Moreno-García: The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes. in Nature reviews. Immunology 2006 (PubMed)
    Show all 4 references for ABIN1001738

  2. Human Polyclonal FYB Primary Antibody for EIA, IF - ABIN499217 : Griffiths, Krawczyk, Kong, Raab, Hyduk, Bouchard, Chan, Kozieradzki, Oliveira-Dos-Santos, Wakeham, Ohashi, Cybulsky, Rudd, Penninger: Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 4 references for ABIN499217

  3. Human Monoclonal FYB Primary Antibody for IF, WB - ABIN968265 : da Silva, Li, de Vera, Canto, Findell, Rudd: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. in Proceedings of the National Academy of Sciences of the United States of America 1997 (PubMed)
    Show all 4 references for ABIN968265

  4. Human Polyclonal FYB Primary Antibody for EIA, IF - ABIN499215 : Medeiros, Burbach, Mueller, Srivastava, Moon, Highfill, Peterson, Shimizu: Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1. in Science (New York, N.Y.) 2007 (PubMed)
    Show all 4 references for ABIN499215

  5. Human Polyclonal FYB Primary Antibody for EIA, WB - ABIN952408 : Lehmann, Meyer, Schuemann, Krause, Freund: A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein. in Proteomics 2009 (PubMed)
    Show all 3 references for ABIN952408

More Antibodies against FYB Interaction Partners

Human FYN-Binding Protein (FYB) interaction partners

  1. A distinct set of proteins interaction partners required for chemokine (show CCL1 Antibodies)-directed T cell migration is attracted by phosphotyrosine 571 of ADAP, including ZAP70 (show ZAP70 Antibodies).

  2. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  3. FYB nonsense mutations in humans causing small-platelet thrombocytopenia and a significant bleeding tendency.

  4. Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 (show TGFB1 Antibodies) production and TGFbeta1 (show TGFB1 Antibodies)-induced CD103 (show ITGAE Antibodies) expression in CD8 (show CD8A Antibodies)+ T-lymphocytes and protects against influenza H5N1 virus infection.

  5. The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset.

  6. The autosomal recessive bleeding phenotype seen in several members of this highly consanguineous family included petechial rash, mild epistaxis and thrombocytopenia with some decrease in platelet volume. These clinical findings, together with the results of exome sequencing pointed to only one strong candidate gene, the FYB gene.

  7. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  8. ADAP and Nck (show NCK1 Antibodies) adapter proteins cooperatively facilitate T cell adhesion to the LFA-1 (show ITGAL Antibodies) ligand ICAM-1 (show ICAM1 Antibodies).

  9. These findings indicate that ADAP regulates two steps of HIV-1 infection cooperatively with two distinct receptors, and as such, serves as a new potential target in the blockade of HIV-1 infection.

  10. our findings indicate an association between polymorphisms located in FYB gene and SLE, suggesting their possible involvement in disease susceptibility and clinical manifestations.

Mouse (Murine) FYN-Binding Protein (FYB) interaction partners

  1. Data (including data from studies in knockout/transgenic mice) suggest that ADAP (show APP Antibodies) regulates positive feedback loop of TGFbeta1 (show TGFB1 Antibodies) production and TGFbeta1 (show TGFB1 Antibodies)-induced CD103 (show ITGAE Antibodies) expression in CD8 (show CD8A Antibodies)+ T-lymphocytes and protects against influenza H5N1 virus infection.

  2. The results indicate that ADAP (show APP Antibodies) dampens naive CD8 (show CD8A Antibodies) T cell responses to lymphopenia and IL-15 (show IL15 Antibodies), and they demonstrate a novel Ag-independent function for ADAP (show APP Antibodies) in the suppression of memory phenotype CD8 (show CD8A Antibodies) T cell generation.

  3. provide evidence that CD28 (show CD28 Antibodies) and the TCR complex regulate NF-kappaB (show NFKB1 Antibodies) via different signaling modules of GRB-2 (show GRB2 Antibodies)/VAV1 (show VAV1 Antibodies) and LAT (show LAT Antibodies)/ADAP (show APP Antibodies) pathways respectively.

  4. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  5. we demonstrate that loss of ADAP (show APP Antibodies) promotes resistance of experimental autoimmune encephalomyelitis in mice, likely by trapping encephalitogenic T cells in the peripheral lymph nodes on LYVE-1 (show LYVE1 Antibodies)+ lymphatic structures.

  6. Signaling by Fyn (show FYN Antibodies)-ADAP (show APP Antibodies) via the Carma1 (show CARD11 Antibodies)-Bcl-10 (show BCL10 Antibodies)-MAP3K7 (show MAP3K7 Antibodies) signalosome exclusively regulates inflammatory cytokine production in NK cells.

  7. integrin activation by the ADAP (show APP Antibodies)-SKAP55 (show SKAP1 Antibodies)-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation.

  8. ADAP (show APP Antibodies) coordinates distinct CARMA1 (show CARD11 Antibodies)-dependent control of key cell cycle proteins in T cells

  9. The authors utilize in vitro systems to map novel phosphotyrosine sites in the C-terminal part of human ADAP (show APP Antibodies) (486-783). They found many phospho-dependent binding partners of ADAP (show APP Antibodies) and confirmed the interaction between ADAP (show APP Antibodies) and Nck (show NCK1 Antibodies), indicating that ADAP (show APP Antibodies) directly links integrins to modulators of the cytoskeleton independent of SLP-76 (show LCP2 Antibodies).

  10. ADAP (show APP Antibodies) plays a role in mediating platelet activation via the collagen-binding integrin alpha(2 (show ITGA2 Antibodies)) beta(1).

FYB Antigen Profile

Antigen Summary

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FYB

  • FYN-binding protein (fyb) antibody
  • FYN binding protein (FYB) antibody
  • FYN binding protein (Fyb) antibody
  • ADAP antibody
  • B630013F22Rik antibody
  • fyb antibody
  • FYB-120/130 antibody
  • p120/130 antibody
  • p120/p130 antibody
  • PRO0823 antibody
  • RGD1563421 antibody
  • SLAP-130 antibody
  • Slap130 antibody

Protein level used designations for FYB

FYN-binding protein , FYB-120/130 , FYN-T-binding protein , SLP-76-associated phosphoprotein , adhesion and degranulation-promoting adaptor protein , p120/p130 , FYN binding protein FYB-130 , adhesion and degranulation promoting adaptor protein , FYN binding protein (FYB-120/130)

GENE ID SPECIES
100195010 Salmo salar
2533 Homo sapiens
23880 Mus musculus
479355 Canis lupus familiaris
535347 Bos taurus
499537 Rattus norvegicus
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