|Antigen||FYN-Binding Protein (FYB) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This FYB antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-FYB AntibodyTarget Details FYB Application Details Handling Images
|Specificity||This antibody recognizes ADAP (C-term).|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||A 20 amino acid peptide from near the carboxy terminus of Human ADAP|
Target Details FYBProduct Details anti-FYB Antibody Application Details Handling Images back to top
|Alternative Name||FYN-Binding Protein (FYB Antibody Abstract)|
|Background||The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.Synonyms: Adhesion and degranulation promoting adaptor protein, FYB-120/130, FYN-T-binding protein, SLAP-130, SLAP130, SLP-76-associated phosphoprotein, p120/p130|
|Pathways||TCR Signaling, Protein targeting to Nucleus|
Application DetailsProduct Details anti-FYB Antibody Target Details FYB Handling Images back to top
ELISA. Western Blot: ADAP antibody can be used for detection of ADAP at 0.5 - 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FYB Antibody Target Details FYB Application Details Images back to top
|Buffer||PBS containing 0.02 % Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|