You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our FYB Proteins (FYB)

Full name:
FYN-Binding Protein Proteins (FYB)
On www.antibodies-online.com are 4 FYN-Binding Protein (FYB) Proteins from 2 different suppliers available. Additionally we are shipping FYB Antibodies (77) and FYB Kits (2) and many more products for this protein. A total of 94 FYB products are currently listed.
Synonyms:
ADAP, B630013F22Rik, fyb, FYB-120/130, p120/130, p120/p130, PRO0823, RGD1563421, SLAP-130, Slap130
list all proteins Gene Name GeneID UniProt
FYB 2533 O15117
FYB 23880 O35601
Rat FYB FYB 499537  

Show all synonyms

FYB Proteins (FYB) by Origin

Select your origin of interest

More Proteins for FYB Interaction Partners

Human FYN-Binding Protein (FYB) interaction partners

  1. A distinct set of proteins interaction partners required for chemokine (show CCL1 Proteins)-directed T cell migration is attracted by phosphotyrosine 571 of ADAP, including ZAP70 (show ZAP70 Proteins).

  2. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  3. FYB nonsense mutations in humans causing small-platelet thrombocytopenia and a significant bleeding tendency.

  4. Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 (show TGFB1 Proteins) production and TGFbeta1 (show TGFB1 Proteins)-induced CD103 (show ITGAE Proteins) expression in CD8 (show CD8A Proteins)+ T-lymphocytes and protects against influenza H5N1 virus infection.

  5. The aim of this study was to perform an association study between seven Fyn-binding protein gene (FYB)-tag single nucleotide polymorphisms (SNPs) and type I diabetes mellitus (T1DM), as well as with disease age of onset.

  6. The autosomal recessive bleeding phenotype seen in several members of this highly consanguineous family included petechial rash, mild epistaxis and thrombocytopenia with some decrease in platelet volume. These clinical findings, together with the results of exome sequencing pointed to only one strong candidate gene, the FYB gene.

  7. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  8. ADAP and Nck (show NCK1 Proteins) adapter proteins cooperatively facilitate T cell adhesion to the LFA-1 (show ITGAL Proteins) ligand ICAM-1 (show ICAM1 Proteins).

  9. These findings indicate that ADAP regulates two steps of HIV-1 infection cooperatively with two distinct receptors, and as such, serves as a new potential target in the blockade of HIV-1 infection.

  10. our findings indicate an association between polymorphisms located in FYB gene and SLE, suggesting their possible involvement in disease susceptibility and clinical manifestations.

Mouse (Murine) FYN-Binding Protein (FYB) interaction partners

  1. Data (including data from studies in knockout/transgenic mice) suggest that ADAP (show APP Proteins) regulates positive feedback loop of TGFbeta1 (show TGFB1 Proteins) production and TGFbeta1 (show TGFB1 Proteins)-induced CD103 (show ITGAE Proteins) expression in CD8 (show CD8A Proteins)+ T-lymphocytes and protects against influenza H5N1 virus infection.

  2. The results indicate that ADAP (show APP Proteins) dampens naive CD8 (show CD8A Proteins) T cell responses to lymphopenia and IL-15 (show IL15 Proteins), and they demonstrate a novel Ag-independent function for ADAP (show APP Proteins) in the suppression of memory phenotype CD8 (show CD8A Proteins) T cell generation.

  3. provide evidence that CD28 (show CD28 Proteins) and the TCR complex regulate NF-kappaB (show NFKB1 Proteins) via different signaling modules of GRB-2 (show GRB2 Proteins)/VAV1 (show VAV1 Proteins) and LAT (show LAT Proteins)/ADAP (show APP Proteins) pathways respectively.

  4. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  5. we demonstrate that loss of ADAP (show APP Proteins) promotes resistance of experimental autoimmune encephalomyelitis in mice, likely by trapping encephalitogenic T cells in the peripheral lymph nodes on LYVE-1 (show LYVE1 Proteins)+ lymphatic structures.

  6. Signaling by Fyn (show FYN Proteins)-ADAP (show APP Proteins) via the Carma1 (show CARD11 Proteins)-Bcl-10 (show BCL10 Proteins)-MAP3K7 (show MAP3K7 Proteins) signalosome exclusively regulates inflammatory cytokine production in NK cells.

  7. integrin activation by the ADAP (show APP Proteins)-SKAP55 (show SKAP1 Proteins)-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation.

  8. ADAP (show APP Proteins) coordinates distinct CARMA1 (show CARD11 Proteins)-dependent control of key cell cycle proteins in T cells

  9. The authors utilize in vitro systems to map novel phosphotyrosine sites in the C-terminal part of human ADAP (show APP Proteins) (486-783). They found many phospho-dependent binding partners of ADAP (show APP Proteins) and confirmed the interaction between ADAP (show APP Proteins) and Nck (show NCK1 Proteins), indicating that ADAP (show APP Proteins) directly links integrins to modulators of the cytoskeleton independent of SLP-76 (show LCP2 Proteins).

  10. ADAP (show APP Proteins) plays a role in mediating platelet activation via the collagen-binding integrin alpha(2 (show ITGA2 Proteins)) beta(1).

FYB Protein Profile

Protein Summary

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FYB

  • FYN-binding protein (fyb)
  • FYN binding protein (FYB)
  • FYN binding protein (Fyb)
  • ADAP protein
  • B630013F22Rik protein
  • fyb protein
  • FYB-120/130 protein
  • p120/130 protein
  • p120/p130 protein
  • PRO0823 protein
  • RGD1563421 protein
  • SLAP-130 protein
  • Slap130 protein

Protein level used designations for FYN-Binding Protein Proteins (FYB)

FYN-binding protein , FYB-120/130 , FYN-T-binding protein , SLP-76-associated phosphoprotein , adhesion and degranulation-promoting adaptor protein , p120/p130 , FYN binding protein FYB-130 , adhesion and degranulation promoting adaptor protein , FYN binding protein (FYB-120/130)

GENE ID SPECIES
100195010 Salmo salar
2533 Homo sapiens
23880 Mus musculus
479355 Canis lupus familiaris
535347 Bos taurus
499537 Rattus norvegicus
Selected quality suppliers for FYB Proteins (FYB)
Did you look for something else?