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These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 (show LCP2 Proteins) complex is required for costimulation by CD6 (show CD6 Proteins).
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2 (show GRB2 Proteins)), Grb2 (show GRB2 Proteins)-related adaptor downstream of Shc (show SHC1 Proteins) (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (show SRC Proteins) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (show CD28 Proteins) with variable affinity
GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 (show LCP2 Proteins) and PLC-gamma1 (show PLCG1 Proteins) phosphorylation but exhibited substantial decrease in TCR-induced IL-2 (show IL2 Proteins) and IFN-gamma (show IFNG Proteins) release.
Gads was dispensable for TCR-induced phosphorylation of SLP-76 (show LCP2 Proteins), but was a dose-dependent amplifier of TCR-induced CD69 (show CD69 Proteins) expression.
GADS mediates lymphoid disease downstream of BCR-ABL (show ABL1 Proteins) through the recruitment of specific signaling intermediates.
Histidine domain-protein tyrosine phosphatase (show ACP1 Proteins) interacts with Grb2 (show GRB2 Proteins) and GrpL
The results show that Bcr-Abl (show ABL1 Proteins) regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76 (show LCP2 Proteins)/Nck1 (show NCK1 Proteins) adaptor protein pathway.
Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase (show MAPK14 Proteins) phosphorylation.
AML-1 (show RUNX1 Proteins) plays a role in driving Mona (show MMP2 Proteins) protein expression in T and myelomonocytic cells.
Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase (show RET Proteins) mitogenic signaling
The combined loss of Gads and CD127 (show IL7R Proteins) reveals a novel function of Gads prior to T cell receptor beta expression
Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein (show GAB3 Proteins) during monocyte/macrophage differentiation. (Gab3 scaffolding protein (show GAB3 Proteins))
Results reveal the basis for preferential recognition of specific LAT (show LAT Proteins) sites by Gads.
Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1 (show MAP4K1 Proteins)) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
The Gads adaptor protein is critical for homeostasis of CD4 (show CD4 Proteins)(+) T cells.
Selective impairment of FcepsilonRI (show FCER1A Proteins)-mediated allergic reaction in Gads-deficient mice
Gads plays a key role in linking the adapter LAT (show LAT Proteins) to SLP-76 (show LCP2 Proteins) in response to weak activation of GPVI (show GP6 Proteins) and CLEC-2 (show CLEC1B Proteins) whereas LAT (show LAT Proteins) is required for full activation over a wider range of agonist concentrations.
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
GRB2-related adaptor protein 2
, GRB2-related adapter protein 2
, GRB-2-like protein
, GRB2-related protein with insert domain
, SH3-SH2-SH3 adapter Mona
, SH3-SH2-SH3 adaptor molecule
, adapter protein GRID
, grf40 adapter protein
, growth factor receptor-binding protein
, growth factor receptor-bound protein 2-related adaptor protein 2
, hematopoietic cell-associated adapter protein GrpL
, hematopoietic cell-associated adaptor protein GRPL
, GRB-2-related monocytic adapter protein
, Grb2-related adaptor downstream of Sch
, hematopoietic cell-associated adaptor protein GrpL
, monocytic adapter
, monocytic adaptor