Browse our HLA-A Proteins (HLA-A)

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Major Histocompatibility Complex, Class I, A Proteins (HLA-A)
On are 44 Major Histocompatibility Complex, Class I, A (HLA-A) Proteins from 3 different suppliers available. Additionally we are shipping HLA-A Antibodies (185) and HLA-A Kits (5) and many more products for this protein. A total of 240 HLA-A products are currently listed.
list all proteins Gene Name GeneID UniProt
HLA-A 3105 P30443 , P04439

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More Proteins for HLA-A Interaction Partners

Human Major Histocompatibility Complex, Class I, A (HLA-A) interaction partners

  1. this study shows that alpha3-deletion isoform of HLA-A11 plays role in the immune escape of HIV-1

  2. Data suggest that personalized peptide vaccine (PPV (show PPP6C Proteins)) with these nine CTL epitope peptides exhibit a good safety profile and positive immunological responses in HLA-A11+ or -A33 (show GPA33 Proteins)+ cancer patients.

  3. findings demonstrate that gliadins contain epitopes that elicit CD8 (show CD8A Proteins)+ T cell responses restricted by HLA class I (show MICA Proteins) A*0101 and B*0801 molecules

  4. Data suggest that only a small fraction of HLA-A*02:01- (HA)-binding ESO peptides are immunogenic, namely those that have high peptide-binding strength and peptide/HA complex stability. This study involved comparison of in silico-predicted and observed cytotoxic T-lymphocyte recognition of tumor antigen epitopes in melanoma patients and transgenic/knockout mice. (ESO = tumor antigen NY-ESO-1 (show CTAG1B Proteins))

  5. The safety, the overall survival (OS), and the immunological responses based on an ELISPOT assay were determined to assess differences in patients who were HLA-A24 (show CD164 Proteins)-positive [24(+)] and HLA-A24 (show CD164 Proteins)-negative [24(-)].

  6. Here we define the nature and extent of the variation in 3,489 HLA-A, 4,356 HLA-B and 3,111 HLA-C alleles. The common alleles of human populations comprise 42 core alleles, which represent all selected polymorphism, and recombinants that have assorted this polymorphism

  7. It was shown that the HLA-A*34 allele is a risk factor for recurrent spontaneous abortion, while the HLA-A*24 and HLA-B*35 alleles are associated with protection, and no allele of the DRB1 locus was associated with recurrent spontaneous abortion

  8. HLA-A alleles were not associated with predisposition to cutaneous leishmaniasis.

  9. a significant level of epitope-specific T cells could be detected ex vivo in peripheral blood mononuclear cells from active TB patients by an HLA-A*11:01 dextramer carrying the peptide Rv3130c194-204.

  10. In conclusion, our results confirm that the alleles HLA-A*02 and HLA-DRB1 (show HLA-DRB1 Proteins)*07 are associated with the pathogenesis of vitiligo (show MITF Proteins) in the Brazilian population. We demonstrated that allele HLA-A*32 is associated with susceptibility to localized vitiligo (show MITF Proteins).

HLA-A Protein Profile

Protein Summary

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

Alternative names and synonyms associated with HLA-A

  • major histocompatibility complex, class I, A (HLA-A)
  • HLAA protein

Protein level used designations for HLA-A

HLA class I histocompatibility antigen, A-1 alpha chain , MHC class I antigen HLA-A heavy chain , antigen presenting molecule , leukocyte antigen class I-A

3105 Homo sapiens
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