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Human HLA-DQB1 ELISA Kit for Sandwich ELISA - ABIN417886
Sillé, Conde, Zhang, Akers, Sanchez, Maltbaek, Riby, Smith, Skibola: Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression. in Genes and immunity 2014
these results confirm an association of HLA-DQB1 alleles and haplotypes with polycystic ovary syndrome susceptibility in Bahraini
HLA-DRB1 (show HLA-DRB1 ELISA Kits)*08:03:02 and HLA-DQB1*06:01:01 are associated with house dust mites (HMD)-sensitive AR and may confer a risk for development of allergic rhinitis in Han Chinese subjects sensitized to HDM (show HDAC3 ELISA Kits).
The DQB1*05:03 allele was associated with pemphigus vulgaris (show DSG3 ELISA Kits) in our study as well as in various populations.
the frequencies of HLA-DRB1 (show HLA-DRB1 ELISA Kits)*03:01 (pc = 0.0378, OR = 4.8) and HLA-DQB1*02:01 (pc = 0.021, OR = 4.8) alleles were significantly higher in patients with JORRP than in controls. In addition, HLA-DRB1 (show HLA-DRB1 ELISA Kits)*03:01 allele significantly correlated with aggressive JORRP
association of DR4/DR8 heterozygous genotype suggested the pathologic importance of trans-complementing DQalpha-beta heterodimer molecules encoded by DQA1 allele of one haplotype and the DQB1 allele of the other haplotype, as it was proposed in the HLA association studies of Type 1 diabetes
This study shows that clearance of HCV is associated with DQB1*03:01:01:01 allele and chronicity of HCV infection associated with the risk allele: DQB1*02:01:01.
HLA-DQB1*06:02 does not seem to be associated with hypoxic ventilatory response or hypercapnic ventilatory response; however there are point wise, uncorrected significant associations between two TASK2/KCNK5 variants (rs2815118 and rs150380866) and hypercapnic ventilatory response
we found that, among Caucasian patients treated with BoNT/A, DQB1*06:04 were higher in Ab-positive than in Ab-negative patients. The genetic linkage was on the threshold of corrected significance.
HLA-DRB1 (show HLA-DRB1 ELISA Kits)*11, -DRB1 (show RBM45 ELISA Kits)*04 and -DQB1*03 allele frequencies between Black patients and healthy Black individuals revealed no significant difference in thrombotic thrombocytopenic purpura, but protective allele against TTP (show ADAMTS13 ELISA Kits), HLA-DRB1 (show HLA-DRB1 ELISA Kits)*04, was dramatically decreased in Black individuals in comparison with White individuals
Our study suggested no significant correlation between narcolepsy, MS and HLA-DQB1*06:02. The HLA-DQB1*06:02 allele alone was not sufficient to cause multiple sclerosis patients to develop narcolepsy.
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.
HLA class II histocompatibility antigen, DQ beta 1 chain
, MHC DQ beta
, MHC class II DQ beta chain
, MHC class II HLA-DQ beta glycoprotein
, MHC class II antigen DQB1
, MHC class II antigen HLA-DQ-beta-1
, MHC class2 antigen
, lymphocyte antigen
, MHC class II DRB antigen
, MHC class II DLA DQ beta chain
, major histocompatibility complex, class II, DQ beta 1