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APOBEC3A/B and HLA-DQA1 are powerful biomarkers for systemic sclerosis risk evaluation and contribute to the susceptibility to systemic sclerosis.
The GG genotype of HLA-DQ rs9277346 was associated with hepatitis B virus infection in the Chinese Han population.
Single-nucleotide polymorphism in HLA-DQA1 gene is associated with primary membranous nephropathy.
The presence of the haplotype HLA-DPA1 (show HLA-DPA1 ELISA Kits)*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1 (show HLA-DPA1 ELISA Kits)*03 and the absence of HLA-DQA*05 with nonallergic asthma.
In the present study, a discriminatory potential of HLA-DQA1/B1 alleles to identify susceptibility to congenital toxoplasmosis and the most severe cases has been shown.
The protective influence of DRB1*15:01-DQA1*01:02-DQB1*06:02 spans from autoantibody development through all stages of progression, and relatives with this allele only rarely develop T1 diabetes.
this study shows detailed DNA methylation status and its correlation with expression of each HLA-DQA1 allele in patients with type 1 diabetes mellitus
The population of a Portuguese Madeira Island is distinguished by the substantial HLA-DQA1 and HLA-DQB1 (show HLA-DQB1 ELISA Kits) allele diversity.
Patients with Latent Autoimmune Diabetes in Adults (LADA) have higher prevalence of thyroid autoimmune diseases. In patients with LADA similarly to type 1 genotype DQA1*0301 seems to CONFER susceptibility to thyroid autoimmunity, and DQB1*0201 to celiac disease.
Two missense SNPs, rs12722042 and 12722039, in the HLA-DQA1 gene yielded the highest effect sizes (odds ratio [OR] approximately 14; P <0.01) for sex-specific results. The HLA-DQA1 SNPs belong to DQA1*01 and confirmed the previously reported male-specific association with DQA1*01. This finding supports the proposed infection-related etiology in childhood ALL risk for males.
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons\; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
DC-1 alpha chain
, HLA class II histocompatibility antigen, DQ alpha 1 chain
, HLA class II histocompatibility antigen, DQ(W3) alpha chain
, MHC HLA-DQ alpha
, MHC class II DQA1
, MHC class II HLA-D alpha glycoprotein
, MHC class II HLA-DQ-alpha-1
, MHC class II antigen
, MHC class II surface glycoprotein
, leucocyte antigen DQA1
, leukocyte antigen alpha chain