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anti-Human ICOS antibody for Enzyme Immunoassay

Recommended ICOS Antibody (supplied by: Log in to see )

Antigen
Inducible T-Cell Co-Stimulator (ICOS) Antibodies
  • ICOS
  • AILIM
  • CCLP
  • CRP-1
  • H4
  • Ly115
  • CD278
  • CVID1
  • Ailim
  • inducible T-cell co-stimulator
  • inducible T cell co-stimulator
  • ICOS
  • LOC100232284
  • Icos
Epitope
C-Term
15
6
5
5
3
2
2
1
1
1
1
Reactivity
Human
89
67
50
4
1
1
Host
Rabbit
58
29
18
12
2
Clonality
Polyclonal
Conjugate
This ICOS antibody is un-conjugated
16
13
9
5
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
53
38
32
25
17
13
11
6
6
4
4
3
3
3
3
2
1
1
1
1
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Catalog No. ABIN358624
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN303433 EIA IHC (p) Rabbit AA 171-186 Log in to see Polyclonal

Top referenced anti-ICOS antibody for Enzyme Immunoassay

Similar anti-ICOS Antibodies

Application / Reactivity Human
Activation (Act) 2 Antibodies
Blocking Reagent (BR) 2 Antibodies
ELISA 21 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies
Flow Cytometry (FACS) 41 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 3 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies
Immunohistochemistry (IHC) 16 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 5 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 18 Antibodies
Immunoprecipitation (IP) 8 Antibodies
Intracellular Flow Cytometry (ICFC) 4 Antibodies
Western Blotting (WB) 26 Antibodies

General

Antigen Inducible T-Cell Co-Stimulator (ICOS) Antibodies
Epitope C-Term
(15), (6), (5), (5), (3), (2), (2), (1), (1), (1), (1)
Reactivity Human
(89), (67), (50), (4), (1), (1)
Host Rabbit
(58), (29), (18), (12), (2)
Clonality
Polyclonal
Conjugate This ICOS antibody is un-conjugated
(16), (13), (9), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(53), (38), (32), (25), (17), (13), (11), (6), (6), (4), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-ICOS Antibody

Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN358624) Images
Specificity This antibody reacts to ICOS.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ICOS.
Isotype Ig

Target Details ICOS

Product Details anti-ICOS Antibody Application Details Handling References for anti-ICOS Antibody (ABIN358624) Images back to top
Antigen
Alternative Name CD278 / ICOS (ICOS Antibody Abstract)
Background ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.Synonyms: AILIM, Activation-inducible lymphocyte immunomediatory molecule, Inducible T-cell costimulator
Gene ID 29851, 9606
UniProt Q9Y6W8
Research Area Immunology, Inflammation
Pathways TCR Signaling

Application Details

Product Details anti-ICOS Antibody Target Details ICOS Handling References for anti-ICOS Antibody (ABIN358624) Images back to top
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-ICOS Antibody Target Details ICOS Application Details References for anti-ICOS Antibody (ABIN358624) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-ICOS Antibody (ABIN358624)

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling Images back to top
Background publications

Okamoto, Tezuka, Kato, Abe, Tsuji: "PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 691-702, 2003

Okamoto, Saito, Yamanaka, Tomatsu, Kamatani, Ogiuchi, Uchiyama, Yagi: "Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis." in: The Journal of rheumatology, Vol. 30, Issue 6, pp. 1157-63, 2003

Riley, Mao, Kobayashi, Biery, Burchard, Cavet, Gregson, June, Linsley: "Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 18, pp. 11790-5, 2002

Haimila, Partanen, Holopainen: "Genetic polymorphism of the human ICOS gene." in: Immunogenetics, Vol. 53, Issue 12, pp. 1028-32, 2002

Witsch, Peiser, Hutloff, Büchner, Dorner, Jonuleit, Mages, Kroczek: "ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells." in: European journal of immunology, Vol. 32, Issue 9, pp. 2680-6, 2002

Images

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN358624) back to top
Supplier Images
 image for anti-ICOS antibody (Inducible T-Cell Co-Stimulator) (C-Term) (ABIN358624) anti-Inducible T-Cell Co-Stimulator (ICOS) (C-Term) antibody
 image for anti-ICOS antibody (Inducible T-Cell Co-Stimulator) (C-Term) (ABIN358624) anti-Inducible T-Cell Co-Stimulator (ICOS) (C-Term) antibody (Image 2)