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anti-Human ICOS antibody for Enzyme Immunoassay

Recommended ICOS Antibody (supplied by: Log in to see )

Antigen
Inducible T-Cell Co-Stimulator (ICOS) Antibodies
  • AILIM
  • Ailim
  • CCLP
  • CD278
  • CRP-1
  • CVID1
  • H4
  • ICOS
  • Ly115
Epitope
C-Term
6
3
2
2
2
1
1
Reactivity
Human
60
57
42
1
Host
Rabbit
33
25
13
10
2
1
Clonality
Polyclonal
Conjugate
This ICOS antibody is un-conjugated
10
8
7
5
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
44
14
13
11
10
7
5
4
4
4
3
3
2
2
1
1
1
1
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Catalog No. ABIN358624
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008867729 ABIN303433 EIA IHC (p) Rabbit AA 171-186 Log in to see Polyclonal

Top referenced anti-ICOS antibody for Enzyme Immunoassay

Similar anti-ICOS Antibodies

Application / Reactivity Human
Activation (Act) 2 Antibodies
Blocking Reagent (BR) 2 Antibodies
ELISA 2 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies
Flow Cytometry (FACS) 32 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 5 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 12 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Intracellular Flow Cytometry (ICFC) 4 Antibodies
Western Blotting (WB) 10 Antibodies

General

Antigen Inducible T-Cell Co-Stimulator (ICOS) Antibodies
Epitope C-Term
(6), (3), (2), (2), (2), (1), (1)
Reactivity Human
(60), (57), (42), (1)
Host Rabbit
(33), (25), (13), (10), (2), (1)
Clonality
Polyclonal
Conjugate This ICOS antibody is un-conjugated
(10), (8), (7), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(44), (14), (13), (11), (10), (7), (5), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-ICOS Antibody

Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN358624) Images
Specificity This antibody reacts to ICOS.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ICOS.
Isotype Ig

Target Details ICOS

Product Details anti-ICOS Antibody Application Details Handling References for anti-ICOS Antibody (ABIN358624) Images back to top
Antigen
Alternative Name CD278 / ICOS (ICOS Antibody Abstract)
Background ICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.Synonyms: AILIM, Activation-inducible lymphocyte immunomediatory molecule, Inducible T-cell costimulator
Gene ID 29851, 9606
UniProt Q9Y6W8
Research Area Immunology, Inflammation
Pathways TCR Signaling

Application Details

Product Details anti-ICOS Antibody Target Details ICOS Handling References for anti-ICOS Antibody (ABIN358624) Images back to top
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-ICOS Antibody Target Details ICOS Application Details References for anti-ICOS Antibody (ABIN358624) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-ICOS Antibody (ABIN358624)

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling Images back to top
Background publications

Okamoto, Tezuka, Kato, Abe, Tsuji: "PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 691-702, 2003

Okamoto, Saito, Yamanaka, Tomatsu, Kamatani, Ogiuchi, Uchiyama, Yagi: "Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis." in: The Journal of rheumatology, Vol. 30, Issue 6, pp. 1157-63, 2003

Riley, Mao, Kobayashi, Biery, Burchard, Cavet, Gregson, June, Linsley: "Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 18, pp. 11790-5, 2002

Haimila, Partanen, Holopainen: "Genetic polymorphism of the human ICOS gene." in: Immunogenetics, Vol. 53, Issue 12, pp. 1028-32, 2002

Witsch, Peiser, Hutloff, Büchner, Dorner, Jonuleit, Mages, Kroczek: "ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells." in: European journal of immunology, Vol. 32, Issue 9, pp. 2680-6, 2002

Images

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN358624) back to top
Supplier Images
 image for anti-ICOS antibody (Inducible T-Cell Co-Stimulator) (C-Term) (ABIN358624) anti-Inducible T-Cell Co-Stimulator (ICOS) (C-Term) antibody
 image for anti-ICOS antibody (Inducible T-Cell Co-Stimulator) (C-Term) (ABIN358624) anti-Inducible T-Cell Co-Stimulator (ICOS) (C-Term) antibody (Image 2)