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anti-Human ICOS antibody for Flow Cytometry

Recommended ICOS Antibody (supplied by: Log in to see )

Antigen
Inducible T-Cell Co-Stimulator (ICOS) Antibodies
  • ICOS
  • AILIM
  • CCLP
  • CRP-1
  • H4
  • Ly115
  • CD278
  • CVID1
  • Ailim
  • inducible T-cell co-stimulator
  • inducible T cell co-stimulator
  • ICOS
  • LOC100232284
  • Icos
Reactivity
Human, Mouse (Murine), Rat (Rattus)
89
66
49
4
1
1
Host
Hamster
59
28
18
12
2
Clonality
Monoclonal
Conjugate
This ICOS antibody is conjugated to PE-Cy7
16
13
9
5
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
52
39
32
25
18
13
11
6
6
4
4
3
3
3
3
2
2
1
1
1
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Catalog No. ABIN2659211
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
13.506455 ABIN2661028 FACS Biotin Hamster IgG Log in to see C398-4A 7
13.506455 ABIN2658571 FACS APC Hamster IgG Log in to see C398-4A 8
13.506455 ABIN2657373 FACS Alexa Fluor 488 Hamster IgG Log in to see C398-4A 7
13.506455 ABIN2657721 FACS ICFC Alexa Fluor 647 Hamster IgG Log in to see C398-4A 7
13.506455 ABIN2661632 FACS FITC Hamster IgG Log in to see C398-4A 7
13.506455 ABIN2662238 FACS Pacific Blue Hamster IgG Log in to see C398-4A 8
13.506455 ABIN2663294 FACS PE Hamster IgG Log in to see C398-4A 7
13.506455 ABIN2660067 Act BR FACS IP IHC WB PerCP-Cy5.5 Hamster IgG Log in to see C398-4A 9
13.506455 ABIN2664489 FACS Hamster IgG Log in to see C398-4A 7
1 ABIN610261 Func FACS ELISA APC Mouse IgG1, kappa Log in to see ANC6C6-A3 2
1 ABIN610262 Func FACS ELISA Mouse IgG1, kappa Log in to see ANC6C6-A3 2
1 ABIN351572 FACS IHC (fro) IP Hamster IgG Log in to see C398-4A
1 ABIN473750 FACS FITC Mouse IgG1, kappa Log in to see ISA-3
1 ABIN475694 FACS Biotin Mouse IgG1, kappa Log in to see ISA-3
1 ABIN476815 FACS Cy7,PE Mouse IgG1, kappa Log in to see ISA-3
1 ABIN477036 FACS PE Mouse IgG1, kappa Log in to see ISA-3
1 ABIN475848 FACS IHC (fro) IP Mouse IgG1, kappa Log in to see ISA-3
1 ABIN2659212 FACS PE-Cy7 Hamster IgG Log in to see C398-4A 8
1 ABIN2661027 FACS Biotin Hamster IgG Log in to see C398-4A 7
1 ABIN2658572 FACS APC Hamster IgG Log in to see C398-4A 8

Top referenced anti-ICOS antibody for Flow Cytometry

Similar anti-ICOS Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus)
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies 1 Antibodies 1 Antibodies
Western Blotting (WB) 26 Antibodies 15 Antibodies 16 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Intracellular Flow Cytometry (ICFC) 4 Antibodies 4 Antibodies 4 Antibodies
Immunoprecipitation (IP) 8 Antibodies 8 Antibodies 7 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 18 Antibodies 5 Antibodies 4 Antibodies
Immunohistochemistry (IHC) 11 Antibodies 16 Antibodies 10 Antibodies

General

Antigen Inducible T-Cell Co-Stimulator (ICOS) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(89), (66), (49), (4), (1), (1)
Host Hamster
(59), (28), (18), (12), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This ICOS antibody is conjugated to PE-Cy7
(16), (13), (9), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS)
(52), (39), (32), (25), (18), (13), (11), (6), (6), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Pubmed 8 references available
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Product Details anti-ICOS Antibody

Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2659211) Images
Cross-Reactivity Rhesus Monkey, Pig (Porcine)
Purification The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.
Clone C398-4A
Isotype IgG

Target Details ICOS

Product Details anti-ICOS Antibody Application Details Handling References for anti-ICOS Antibody (ABIN2659211) Images back to top
Antigen
Alternative Name CD278 (ICOS Antibody Abstract)
Background ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.
Pathways TCR Signaling

Application Details

Product Details anti-ICOS Antibody Target Details ICOS Handling References for anti-ICOS Antibody (ABIN2659211) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-ICOS Antibody Target Details ICOS Application Details References for anti-ICOS Antibody (ABIN2659211) Images back to top
Concentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-ICOS Antibody (ABIN2659211)

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling Images back to top
Background publications

Herati, Reuter, Dolfi, Mansfield, Aung, Badwan, Kurupati, Kannan, Ertl, Schmader, Betts, Canaday, Wherry: "Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 7, pp. 3528-37, 2014

Arimura, Shiroki, Kuwahara, Kato, Dianzani, Uchiyama, Yagi: "Akt is a neutral amplifier for Th cell differentiation." in: The Journal of biological chemistry, Vol. 279, Issue 12, pp. 11408-16, 2004

Yagi, Arimura, Dianzani, Uede, Okamoto, Uchiyama: "Regulatory roles of IL-2 and IL-4 in H4/inducible costimulator expression on activated CD4+ T cells during Th cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 2, pp. 783-94, 2003

Arimura, Kato, Dianzani, Okamoto, Kamekura, Buonfiglio, Miyoshi-Akiyama, Uchiyama, Yagi: "A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses." in: International immunology, Vol. 14, Issue 6, pp. 555-66, 2002

Buonfiglio, Bragardo, Redoglia, Vaschetto, Bottarel, Bonissoni, Bensi, Mezzatesta, Janeway Jr, Dianzani: "The T cell activation molecule H4 and the CD28-like molecule ICOS are identical." in: European journal of immunology, Vol. 30, Issue 12, pp. 3463-7, 2001

Coyle, Lehar, Lloyd, Tian, Delaney, Manning, Nguyen, Burwell, Schneider, Gonzalo, Gosselin, Owen, Rudd, Gutierrez-Ramos: "The CD28-related molecule ICOS is required for effective T cell-dependent immune responses." in: Immunity, Vol. 13, Issue 1, pp. 95-105, 2000

Hutloff, Dittrich, Beier, Eljaschewitsch, Kraft, Anagnostopoulos, Kroczek: "ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28." in: Nature, Vol. 397, Issue 6716, pp. 263-6, 1999

Redoglia, Dianzani, Rojo, Portolés, Bragardo, Wolff, Buonfiglio, Bonissoni, Janeway: "Characterization of H4: a mouse T lymphocyte activation molecule functionally associated with the CD3/T cell receptor." in: European journal of immunology, Vol. 26, Issue 11, pp. 2781-9, 1997

Images

Product Details anti-ICOS Antibody Target Details ICOS Application Details Handling References for anti-ICOS Antibody (ABIN2659211) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-ICOS antibody (Inducible T-Cell Co-Stimulator)  (PE-Cy7) (ABIN2659211) anti-Inducible T-Cell Co-Stimulator (ICOS) antibody (PE-Cy7)