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anti-Human IL17A antibody for Mass Cytometry

Recommended IL17A Antibody (supplied by: Log in to see )

Antigen
Interleukin 17A (IL17A) Antibodies
  • ChIL-17
  • Ctla-8
  • CTLA-8
  • CTLA8
  • Ctla8
  • IL-17
  • IL-17A
  • IL-17F
  • IL17
  • Il17
  • IL17A
Reactivity
Human
430
194
72
10
5
5
1
Host
Mouse
247
207
111
44
8
3
1
Clonality
Monoclonal
Conjugate
This IL17A antibody is conjugated to PE-Cy7
71
34
34
24
17
16
14
11
8
7
7
7
7
7
7
7
7
7
6
5
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
Application
Flow Cytometry (FACS), Mass Cytometry (CyTOF)
345
312
192
59
43
42
24
22
19
15
11
10
9
9
9
8
7
6
5
4
4
3
2
2
2
2
2
1
1
1
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Catalog No. ABIN2659614
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Top referenced anti-IL17A antibody for Mass Cytometry

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Application / Reactivity Human
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General

Antigen Interleukin 17A (IL17A) Antibodies
Reactivity Human
(430), (194), (72), (10), (5), (5), (1)
Host Mouse
(247), (207), (111), (44), (8), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL17A antibody is conjugated to PE-Cy7
(71), (34), (34), (24), (17), (16), (14), (11), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (5), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Flow Cytometry (FACS), Mass Cytometry (CyTOF)
(345), (312), (192), (59), (43), (42), (24), (22), (19), (15), (11), (10), (9), (9), (9), (8), (7), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-IL17A Antibody

Target Details IL17A Application Details Handling References for anti-IL17A Antibody (ABIN2659614) Images
Purification The antibody was purified by affinity chromatography, and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.
Clone BL168
Isotype IgG1 kappa

Target Details IL17A

Product Details anti-IL17A Antibody Application Details Handling References for anti-IL17A Antibody (ABIN2659614) Images back to top
Antigen
Alternative Name IL-17A (IL17A Antibody Abstract)
Background IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63 % , 63 %, and 72 % amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.
Pathways TCR Signaling

Application Details

Product Details anti-IL17A Antibody Target Details IL17A Handling References for anti-IL17A Antibody (ABIN2659614) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL17A Antibody Target Details IL17A Application Details References for anti-IL17A Antibody (ABIN2659614) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL17A Antibody (ABIN2659614)

Product Details anti-IL17A Antibody Target Details IL17A Application Details Handling Images back to top
Background publications

Tchakoute, Hesseling, Kidzeru, Gamieldien, Passmore, Jones, Gray, Sodora, Jaspan: "Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants." in: The Journal of infectious diseases, Vol. 211, Issue 3, pp. 338-46, 2015

Witowski, Ksiazek, Warnecke, Kuźlan, Korybalska, Tayama, Wiśniewska-Elnur, Pawlaczyk, Trómińska, Breborowicz, Jörres: "Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum." in: Kidney international, Vol. 71, Issue 6, pp. 514-25, 2007

Hirota, Hashimoto, Yoshitomi, Tanaka, Nomura, Yamaguchi, Iwakura, Sakaguchi, Sakaguchi: "T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis." in: The Journal of experimental medicine, Vol. 204, Issue 1, pp. 41-7, 2007

Furuzawa-Carballeda, Vargas-Rojas, Cabral: "Autoimmune inflammation from the Th17 perspective." in: Autoimmunity reviews, Vol. 6, Issue 3, pp. 169-75, 2007

Gaffen, Kramer, Yu, Shen: "The IL-17 cytokine family." in: Vitamins and hormones, Vol. 74, pp. 255-82, 2006

Hymowitz, Filvaroff, Yin, Lee, Cai, Risser, Maruoka, Mao, Foster, Kelley, Pan, Gurney, de Vos, Starovasnik: "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding." in: The EMBO journal, Vol. 20, Issue 19, pp. 5332-41, 2001

Images

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Supplier Images
Flow Cytometry (FACS) image for anti-IL17A antibody (Interleukin 17A)  (PE-Cy7) (ABIN2659614) anti-Interleukin 17A (IL17A) antibody (PE-Cy7)