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anti-Human IL17A antibody for Depletion

Recommended IL17A Antibody (supplied by: Log in to see )

Antigen
Interleukin 17A (IL17A) Antibodies
  • ChIL-17
  • Ctla-8
  • CTLA-8
  • CTLA8
  • Ctla8
  • IL-17
  • IL-17A
  • IL-17F
  • IL17
  • Il17
  • IL17A
Reactivity
Human
430
194
72
10
5
5
1
Host
Mouse
247
207
111
44
8
3
1
Clonality
Monoclonal
Conjugate
This IL17A antibody is un-conjugated
71
34
34
24
17
16
14
11
8
7
7
7
7
7
7
7
7
7
6
6
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
Application
Depletion (Dep), Flow Cytometry (FACS), Immunohistochemistry (IHC)
345
312
192
58
43
42
24
22
19
15
11
10
9
9
9
8
7
6
5
4
4
3
2
2
2
2
2
1
1
1
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Catalog No. ABIN2665119
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Top referenced anti-IL17A antibody for Depletion

Similar anti-IL17A Antibodies

Application / Reactivity Human
Biochemical Assay (BCA) 3 Antibodies
Blocking Antibody (Inhibition) 3 Antibodies
Blocking Reagent (BR) 2 Antibodies
Confocal Microscopy (CM) 2 Antibodies
Depletion (Dep) 1 Antibodies
ELISA 193 Antibodies
ELISA (Capture) 7 Antibodies
ELISA (Detection) 8 Antibodies
ELISpot 9 Antibodies
ELISpot (Capture) (ELISPOT (Capture)) 3 Antibodies
ELISpot (Detection) (ELISPOT (Detection)) 1 Antibodies
Enzyme Immunoassay (EIA) 11 Antibodies
Flow Cytometry (FACS) 118 Antibodies
Functional Studies (Func) 9 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 5 Antibodies
Immunofluorescence (IF) 10 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 31 Antibodies

General

Antigen Interleukin 17A (IL17A) Antibodies
Reactivity Human
(430), (194), (72), (10), (5), (5), (1)
Host Mouse
(247), (207), (111), (44), (8), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL17A antibody is un-conjugated
(71), (34), (34), (24), (17), (16), (14), (11), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (6), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Depletion (Dep), Flow Cytometry (FACS), Immunohistochemistry (IHC)
(345), (312), (192), (58), (43), (42), (24), (22), (19), (15), (11), (10), (9), (9), (9), (8), (7), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-IL17A Antibody

Target Details IL17A Application Details Handling References for anti-IL17A Antibody (ABIN2665119) Images
Purification The antibody was purified by affinity chromatography.
Clone BL23
Isotype IgG1 kappa

Target Details IL17A

Product Details anti-IL17A Antibody Application Details Handling References for anti-IL17A Antibody (ABIN2665119) Images back to top
Antigen
Alternative Name IL-17A (IL17A Antibody Abstract)
Background IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63 % , 63 % and 72 % amino acid sequence identity to rat IL-17A, mouse IL-17A and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.
Pathways TCR Signaling

Application Details

Product Details anti-IL17A Antibody Target Details IL17A Handling References for anti-IL17A Antibody (ABIN2665119) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL17A Antibody Target Details IL17A Application Details References for anti-IL17A Antibody (ABIN2665119) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL17A Antibody (ABIN2665119)

Product Details anti-IL17A Antibody Target Details IL17A Application Details Handling Images back to top
Background publications

Furuzawa-Carballeda, Vargas-Rojas, Cabral: "Autoimmune inflammation from the Th17 perspective." in: Autoimmunity reviews, Vol. 6, Issue 3, pp. 169-75, 2007

Witowski, Ksiazek, Warnecke, Kuźlan, Korybalska, Tayama, Wiśniewska-Elnur, Pawlaczyk, Trómińska, Breborowicz, Jörres: "Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum." in: Kidney international, Vol. 71, Issue 6, pp. 514-25, 2007

Hirota, Hashimoto, Yoshitomi, Tanaka, Nomura, Yamaguchi, Iwakura, Sakaguchi, Sakaguchi: "T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis." in: The Journal of experimental medicine, Vol. 204, Issue 1, pp. 41-7, 2007

Gaffen, Kramer, Yu, Shen: "The IL-17 cytokine family." in: Vitamins and hormones, Vol. 74, pp. 255-82, 2006

Hymowitz, Filvaroff, Yin, Lee, Cai, Risser, Maruoka, Mao, Foster, Kelley, Pan, Gurney, de Vos, Starovasnik: "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding." in: The EMBO journal, Vol. 20, Issue 19, pp. 5332-41, 2001