We are preparing the requested document. Please wait, this may take a while...!
|Application / Reactivity||Human|
|Biochemical Assay (BCA)||3 Antibodies|
|Blocking Antibody (Inhibition)||3 Antibodies|
|Blocking Reagent (BR)||2 Antibodies|
|Confocal Microscopy (CM)||2 Antibodies|
|Depletion (Dep)||1 Antibodies|
|ELISA (Capture)||7 Antibodies|
|ELISA (Detection)||8 Antibodies|
|ELISpot (Capture) (ELISPOT (Capture))||3 Antibodies|
|ELISpot (Detection) (ELISPOT (Detection))||1 Antibodies|
|Enzyme Immunoassay (EIA)||11 Antibodies|
|Flow Cytometry (FACS)||78 Antibodies|
|Functional Studies (Func)||9 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies|
|Immunofluorescence (IF)||10 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||30 Antibodies|
|Antigen||Interleukin 17A (IL17A) Antibodies|
|Conjugate||This IL17A antibody is conjugated to PerCP-Cy5.5 Alternatives|
Intracellular Flow Cytometry (ICFC)
|5 references available|
|Supplier||Log in to see|
Product Details anti-IL17A AntibodyTarget Details IL17A Application Details Handling References for anti-IL17A Antibody (ABIN2660499) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.|
Target Details IL17AProduct Details anti-IL17A Antibody Application Details Handling References for anti-IL17A Antibody (ABIN2660499) Images back to top
|Alternative Name||IL-17A (IL17A Antibody Abstract)|
|Background||IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts, the enhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63 % , 63 %, and 72 % amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.|
Application DetailsProduct Details anti-IL17A Antibody Target Details IL17A Handling References for anti-IL17A Antibody (ABIN2660499) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL17A Antibody Target Details IL17A Application Details References for anti-IL17A Antibody (ABIN2660499) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL17A Antibody (ABIN2660499)Product Details anti-IL17A Antibody Target Details IL17A Application Details Handling Images back to top
Furuzawa-Carballeda, Vargas-Rojas, Cabral: "Autoimmune inflammation from the Th17 perspective." in: Autoimmunity reviews, Vol. 6, Issue 3, pp. 169-75, 2007 (PubMed).
Witowski, Ksiazek, Warnecke et al.: "Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum." in: Kidney international, Vol. 71, Issue 6, pp. 514-25, 2007 (PubMed).
Hirota, Hashimoto, Yoshitomi et al.: "T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis." in: The Journal of experimental medicine, Vol. 204, Issue 1, pp. 41-7, 2007 (PubMed).
Gaffen, Kramer, Yu et al.: "The IL-17 cytokine family." in: Vitamins and hormones, Vol. 74, pp. 255-82, 2006 (PubMed).
Hymowitz, Filvaroff, Yin et al.: "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding." in: The EMBO journal, Vol. 20, Issue 19, pp. 5332-41, 2001 (PubMed).
ImagesProduct Details anti-IL17A Antibody Target Details IL17A Application Details Handling References for anti-IL17A Antibody (ABIN2660499) back to top