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anti-Mouse (Murine) IL17A antibody for Intracellular Flow Cytometry

Recommended IL17A Antibody (supplied by: Log in to see )

Antigen
Interleukin 17A (IL17A) Antibodies
  • ChIL-17
  • Ctla-8
  • CTLA-8
  • CTLA8
  • Ctla8
  • IL-17
  • IL-17A
  • IL-17F
  • IL17
  • Il17
  • IL17A
Reactivity
Mouse (Murine)
431
193
72
10
5
5
1
Host
Rat
248
207
110
44
8
3
1
Clonality
Monoclonal
Conjugate
This IL17A antibody is conjugated to FITC
71
34
33
24
17
16
14
11
8
7
7
7
7
7
7
7
7
7
6
6
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
Application
Intracellular Flow Cytometry (ICFC)
345
312
193
59
43
42
24
22
19
15
11
10
9
9
9
8
7
6
5
4
3
3
2
2
2
2
2
1
1
1
1
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Catalog No. ABIN2661940
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008723967 ABIN2661939 ICFC FITC Rat IgG1 kappa Log in to see TC11-18H10-1 11

Top referenced anti-IL17A antibody for Intracellular Flow Cytometry

Similar anti-IL17A Antibodies

Application / Reactivity Mouse (Murine)
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Blocking Antibody (Inhibition) 3 Antibodies
Confocal Microscopy (CM) 2 Antibodies
ELISA 110 Antibodies
ELISA (Capture) 1 Antibodies
ELISA (Detection) 1 Antibodies
ELISpot (Capture) (ELISPOT (Capture)) 2 Antibodies
ELISpot (Detection) (ELISPOT (Detection)) 1 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies
FLISA 1 Antibodies
Flow Cytometry (FACS) 75 Antibodies
Immunocytochemistry (ICC) 4 Antibodies
Immunofluorescence (IF) 14 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 32 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 23 Antibodies
Immunoprecipitation (IP) 4 Antibodies

General

Antigen Interleukin 17A (IL17A) Antibodies
Reactivity Mouse (Murine)
(431), (193), (72), (10), (5), (5), (1)
Host Rat
(248), (207), (110), (44), (8), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL17A antibody is conjugated to FITC
(71), (34), (33), (24), (17), (16), (14), (11), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (6), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Intracellular Flow Cytometry (ICFC)
(345), (312), (193), (59), (43), (42), (24), (22), (19), (15), (11), (10), (9), (9), (9), (8), (7), (6), (5), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 11 references available
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Product Details anti-IL17A Antibody

Target Details IL17A Application Details Handling References for anti-IL17A Antibody (ABIN2661940) Images
Purification The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Clone TC11-18H10-1
Isotype IgG1 kappa

Target Details IL17A

Product Details anti-IL17A Antibody Application Details Handling References for anti-IL17A Antibody (ABIN2661940) Images back to top
Antigen
Alternative Name IL-17A (IL17A Antibody Abstract)
Background IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
Pathways TCR Signaling

Application Details

Product Details anti-IL17A Antibody Target Details IL17A Handling References for anti-IL17A Antibody (ABIN2661940) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL17A Antibody Target Details IL17A Application Details References for anti-IL17A Antibody (ABIN2661940) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL17A Antibody (ABIN2661940)

Product Details anti-IL17A Antibody Target Details IL17A Application Details Handling Images back to top
Background publications

Smith, Stark, Zarbock, Burcin, Bruce, Vaswani, Foley, Ley: "IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 2, pp. 1357-64, 2008

Ehirchiou, Xiong, Xu, Chen, Shi, Zhang: "CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation." in: The Journal of experimental medicine, Vol. 204, Issue 7, pp. 1519-24, 2007

Kang, Lim, Andrisani, Broxmeyer, Kim: "Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 6, pp. 3724-33, 2007

Dong: "Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells." in: Nature reviews. Immunology, Vol. 6, Issue 4, pp. 329-33, 2006

Hofstetter, Ibrahim, Koczan, Kruse, Weishaupt, Toyka, Gold: "Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis." in: Cellular immunology, Vol. 237, Issue 2, pp. 123-30, 2006

Yen, Cheung, Scheerens, Poulet, McClanahan, McKenzie, Kleinschek, Owyang, Mattson, Blumenschein, Murphy, Sathe, Cua, Kastelein, Rennick: "IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6." in: The Journal of clinical investigation, Vol. 116, Issue 5, pp. 1310-6, 2006

Schubert, Maier, Morawietz, Krenn, Kamradt: "Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 7, pp. 4503-9, 2004

Infante-Duarte, Horton, Byrne, Kamradt: "Microbial lipopeptides induce the production of IL-17 in Th cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6107-15, 2000

Yao, Spriggs, Derry, Strockbine, Park, VandenBos, Zappone, Painter, Armitage: "Molecular characterization of the human interleukin (IL)-17 receptor." in: Cytokine, Vol. 9, Issue 11, pp. 794-800, 1998

Kennedy, Rossi, Zurawski, Vega, Kastelein, Wagner, Hannum, Zlotnik: "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 16, Issue 8, pp. 611-7, 1997

Fossiez, Djossou, Chomarat, Flores-Romo, Ait-Yahia, Maat, Pin, Garrone, Garcia, Saeland, Blanchard, Gaillard, Das Mahapatra, Rouvier, Golstein, Banchereau, Lebecque: "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." in: The Journal of experimental medicine, Vol. 183, Issue 6, pp. 2593-603, 1996

Images

Product Details anti-IL17A Antibody Target Details IL17A Application Details Handling References for anti-IL17A Antibody (ABIN2661940) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-IL17A antibody (Interleukin 17A)  (FITC) (ABIN2661940) anti-Interleukin 17A (IL17A) antibody (FITC)