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Human IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413453
Bérubé, Roussel, Nattagh, Rousseau et al.: Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ... in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413456
Arif, Moore, Marks, Bouckenooghe, Dayan, Planas, Vives-Pi, Powrie, Tree, Marchetti, Huang, Gurzov, Pujol-Borrell, Eizirik, Peakman: Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. in Diabetes 2011
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN5570899
Yao, Weng, Zhang, Feng, Lin, Yao: Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons. in Molecular neurobiology 2016
cyanidin specifically recognizes an IL-17A binding site in the IL-17A receptor subunit (IL-17RA (show IL17RA Proteins)) and inhibits the IL-17A/IL-17RA (show IL17RA Proteins) interaction.
IL17A and IL17F (show IL17F Proteins) gene polymorphism are not the important factors associated with susceptibility and some clinical parameters of rheumatoid arthritis in a Polish population.
IL-17A may limit the extent of bone formation at inflamed periosteal sites in spondyloarthritis
These findings indicate that IL-17 directly acts on bronchial smooth muscle (BSM) cells and up-regulates RhoA protein probably via a down-regulation of miR-133a-3p, resulting in an induction of BSM hyperresponsiveness.
serum levels determined of both T cell polarizing (IL- 33 (show IL33 Proteins) and IL-12 (show IL12A Proteins)) and T cell effector (IFN-gamma (show IFNG Proteins), IL-4 (show IL4 Proteins), IL-10 (show IL10 Proteins), IL-17 and IL-9 (show IL9 Proteins)) cytokines in T1DM (type-1 Diabetes Mellitus) subjects with and without microvascular complications (MVC). All the tested cytokines were significantly elevated in T1DM subjects except for IFN-gamma (show IFNG Proteins) with no significant difference between those with and without MVC.
IL-17 can induce A549 alveolar epithelial cells to undergo epithelial-mesenchymal transition via the TGF-beta1 mediated Smad2/3 and ERK1/2 activation
Th17 cells and IL-17 increased autophagy of RA FLSs by causing mitochondrial dysfunction. Our findings suggest that, in RA, interactions between RA FLSs and Th17 cells may be involved in the tumorous growth of FLSs and the formation of pannus in joints
high IL-17 expression was an indicator of poor prognosis for Chinese patients with lung cancer
This review demonstrates an understanding on how the pro- or antitumor function of Th17 cells and IL-17 may change cancer progression, leading to the appearance of complex and pivotal biologic activities in tumor. [review]
An increase in neutrophils and an upregulation of interleukin-17 responses have been documented in periodontitis.
Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO (show AOC2 Proteins)) horses.
cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells
This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
In both the high-glucose - treated Muller cells and Akita mouse retina, the Act1 (show TRAF3IP2 Proteins)/TRAF6 (show TRAF6 Proteins)/IKK (show CHUK Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathway was activated. IL-17A further enhanced inflammatory signaling activation, whereas Act1 (show TRAF3IP2 Proteins) knockdown or IKK (show CHUK Proteins) inhibition blocked the downstream signaling activation by IL-17A.
this study shows that local production of IL-17A by innate lymphoid cells is crucial for the development of intestinal IR injury
These data thus reveal that HDAC6 (show HDAC6 Proteins) represses IL-17 production in T cells, providing novel insights into the role of HDAC6 (show HDAC6 Proteins) in the immune system.
Data indicate that IL-2 (show IL2 Proteins) can augment the gammadeltaT-17 response in favor of short-lived effectors with limited plasticity, particularly in the presence of IL-1beta (show IL1B Proteins) and IL-23 (show IL23A Proteins). In this way, IL-2 (show IL2 Proteins) may act to curtail the innate-like response of gammadeltaT-17 cells upon arrival of IL-2 (show IL2 Proteins)-producing adaptive immune cells at the site of inflammation.
Rhinovirus inhibits IL-17A and the downstream immune responses in allergic asthma.
These data support the conclusion that IL-17A contributes to middle ear injury through the p38 MAPK (show MAPK14 Proteins) signaling pathway.
this study describes regulation of IL-17A expression in mice following subacute ozone exposure
impact of IL-6 on the Th9/Th17 balance depending on the predominant cytokine milieu; data suggest that the IL-6-mediated reduction of Th2-related IL-4 leads to a decline of the Th9 immune response and allows Th17 differentiation
these results identify a distinct pathway in which IL-17 production by splenic LSK (show LCK Proteins)- cells supports their differentiation into B cells in response to acute Plasmodium infection
calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.
Data show that CD4 (show CD4 Proteins)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.
IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.
IL-17A and IL-17F (show IL17F Proteins) have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.
The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.
At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8 (show CD8A Proteins)+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.
Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.
conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3 (show CD3 Proteins)(+)CD4 (show CD4 Proteins)(+) and CD3 (show CD3 Proteins)(+)gammadeltaTCR(+).
Cloning and expression of interleukin-17.
Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.
molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.
one of the interaction sites between IL17A and its receptor IL17RA (show IL17RA Proteins)
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
, cytotoxic T-lymphocyte-associated antigen 8
, cytotoxic T-lymphocyte-associated protein 8
, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
, interleukin 17
, interleukin 17A
, Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)