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Mouse (Murine) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN2667468
Ouyang, Kolls, Zheng: The biological functions of T helper 17 cell effector cytokines in inflammation. in Immunity 2008
Show all 10 references for ABIN2667468
Human IL17A Protein expressed in Escherichia coli (E. coli) - ABIN2667466
Yu, Gaffen: Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity. in Frontiers in bioscience : a journal and virtual library 2007
Show all 7 references for ABIN2667466
Human IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413453
Bérubé, Roussel, Nattagh, Rousseau et al.: Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ... in The Journal of biological chemistry 2010
Show all 3 references for ABIN413453
Rat (Rattus) IL17A Protein expressed in Escherichia coli (E. coli) - ABIN413456
Arif, Moore, Marks, Bouckenooghe, Dayan, Planas, Vives-Pi, Powrie, Tree, Marchetti, Huang, Gurzov, Pujol-Borrell, Eizirik, Peakman: Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death. in Diabetes 2011
Data indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.
this study shows that the serum levels of IL-17 are higher in Iranian diabetes type I patients compared to the healthy individuals
The plasma IL-17 was higher in boys, whereas plasma adiponectin (show ADIPOQ Proteins) and leptin (show LEP Proteins) were significantly higher in girls. In all participants, obesity status and plasma leptin (show LEP Proteins) were the most efficient predictors of insulin (show INS Proteins) resistance, whereas the IL-17 could not significantly predict insulin (show INS Proteins) resistance.
The rs2275913 polymorphism of the IL17A gene was associated with susceptibility to Henoch-Schonlein purpura in Chinese children.
the IL-17A rs2275913 G > A gene polymorphism was significantly associated with an increased risk of gastric cancer in co-dominant, dominant, and recessive models.
the effect of HSP90 (show HSP90 Proteins) inhibition on IL-17-mediated cytokine and antimicrobial peptide (show cAMP Proteins) expression in keratinocytes following heat treatment, was examined.
The presence of higher IL-13 (show IL13 Proteins) and IL-17 serum levels in patients, compared with those of controls, confirms that these markers, found with high specificity, might be involved in the pathogenesis of eRA. IL-13 (show IL13 Proteins) and IL-17 might be of better usefulness in the prediction of eRA activity status than IgM-RF and anti-CCP (show CRYGD Proteins).
Findings demonstrated that IL-17A could promote the invasion of colorectal cancer cells by activating the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling pathway and subsequently upregulating the expression of MMP-2 (show MMP2 Proteins)/9.
IL17A gene polymorphisms confer susceptibility to coronary artery disease.
MiR (show MLXIP Proteins)-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 (show TRAF6 Proteins) and affecting the IL-17/ICAM-1 (show ICAM1 Proteins) pathway.
Associations of rs8193037 in the promoter of IL17A with the risk of congestive heart failure, and of rs4819554 in the promoter of IL17RA (show IL17RA Proteins) with the risk of cardiovascular mortality in patients with congestive heart failure. These data lend further support to the notion that immune activation and genetic polymorphisms contribute to heart failure pathogenesis and progression.
These results demonstrate that IL-17 is not required for development of severe pathology in response to infection with Borrelia burgdorferi, but may contribute to disease through an interaction with IFN-gamma (show IFNG Proteins).
Results indicate that IL-17A promotes tumorigenicity of colon cancer cells by enhancing cell cycle progression and directly induces the expression of Sca-1.
In conclusion, the data demonstrate that endogenous IL-17 may be a factor determining the severity of CDI in mice.
Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.
Th17 cells/Il17A participate in the pathogenesis of skin and lung fibrosis by enhancing fibroblast proliferation and cytokine production in a mouse bleomycin model of systemic sclerosis.
These data provide a mechanism where IL-17A affects bone formation by regulating Wnt (show WNT2 Proteins) signaling in osteoblasts and osteocytes.
study shows that airway oxidative inflammation may contribute to systemic inflammation through upregulation of IL-17A
IL-17 was shown not to be essential for pathology induction and chronic pelvic pain development in a mouse model.
IL-17A Induces adipokine expression in adipocytes. IL-17A differentially induces inflammatory gene expression in pre-adipocytes and adipocytes. IL-17A levels were higher in obese subcutaneous adipose tissue than lean subcutaneous adipose tissue.
The novel findings reveal the critical role of NLRP12 (show NLRP12 Proteins)-IL-17A-CXCL1 (show CXCL1 Proteins) axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae.
At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8 (show CD8A Proteins)+ T cell, gammadelta T cell and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localized skin IL-17-secreting T cells may play a critical role in the pathogenesis of crusted scabies development.
Alterations in the IL-17 regulated pathway of porcine colon in response to dietary supplementation with seaweeds and yeast are reported.
conclude that only two subpopulations of porcine WBCs are sources of IL-17 after non-specific stimulation: CD3 (show CD3 Proteins)(+)CD4 (show CD4 Proteins)(+) and CD3 (show CD3 Proteins)(+)gammadeltaTCR(+).
Cloning and expression of interleukin-17.
calves, like humans, mount a robust IL-17 response during respiratory syncytial virus infection.
Data show that CD4 (show CD4 Proteins)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 termed Th17 and gammadelta17 cells.
IL-17A was shown to be upregulated, supporting its investigation as a potential biomarker of bTB.
IL-17A and IL-17F (show IL17F Proteins) have a potential to modulate the mammary gland immune response to mastitis-causing pathogens.
The results of this study provide evidence of the role of IL-17 in the immunopathology of tuberculosis and support the use of IL-17 as a potential biomarker with predictive value of prognosis in bTB.
Data show increased interleukin 17 (IL-17) staining intensity in mediastinal lymph node from chronic recurrent airway obstruction (RAO (show AOC2 Proteins)) horses.
cloning and characterization of interleukin-17 expressed gene sequence from mRNA obtained from intestinal tissue and interleukin-23 expressed gene sequence from mRNA obtained from peripheral blood mononuclear cells
This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.
molecular cloning and expression of recombinant IL-17A; homology modeling revealed that the three-dimensional structure resembles that of human IL-17A. The secondary structure predicted showed the presence of one extra helix in the N-terminal region.
one of the interaction sites between IL17A and its receptor IL17RA (show IL17RA Proteins)
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
, Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
, cytotoxic T-lymphocyte-associated antigen 8
, cytotoxic T-lymphocyte-associated protein 8
, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
, interleukin 17