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anti-Mouse (Murine) LAT antibody for Flow Cytometry

Recommended LAT Antibody (supplied by: Log in to see )

Antigen
Linker For Activation of T Cells (LAT) Antibodies
  • LAT
  • lat
  • LAT1
  • pp36
Reactivity
Human, Mouse (Murine)
189
83
75
1
1
1
1
Host
Mouse
131
53
13
2
Clonality
Monoclonal
Conjugate
This LAT antibody is un-conjugated
7
7
5
5
5
5
3
3
3
3
3
3
3
2
1
Application
Flow Cytometry (FACS)
138
68
33
29
27
19
9
9
6
2
2
2
2
2
1
1
Supplier
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Available images

Catalog No. ABIN2666055
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0010444935 ABIN2666056 FACS Mouse IgG1 kappa Log in to see 11B-12 4

Top referenced anti-LAT antibody for Flow Cytometry

Similar anti-LAT Antibodies

Application / Reactivity Mouse (Murine) Human
Western Blotting (WB) 50 Antibodies 132 Antibodies
Intracellular Staining (ICS) 6 Antibodies
Immunoprecipitation (IP) 4 Antibodies 25 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 26 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 19 Antibodies 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies 1 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 33 Antibodies 33 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunocytochemistry (ICC) 4 Antibodies 4 Antibodies
Immunochromatography (IC) 1 Antibodies

General

Antigen Linker For Activation of T Cells (LAT) Antibodies
Reactivity Human, Mouse (Murine)
(189), (83), (75), (1), (1), (1), (1)
Host Mouse
(131), (53), (13), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This LAT antibody is un-conjugated
(7), (7), (5), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (2), (1)
Application Flow Cytometry (FACS)
(138), (68), (33), (29), (27), (19), (9), (9), (6), (2), (2), (2), (2), (2), (1), (1)
Pubmed 4 references available
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Product Details anti-LAT Antibody

Target Details LAT Application Details Handling References for anti-LAT Antibody (ABIN2666055) Images
Cross-Reactivity Mouse (Murine)
Purification The antibody was purified by affinity chromatography.
Clone 11B-12
Isotype IgG1 kappa

Target Details LAT

Product Details anti-LAT Antibody Application Details Handling References for anti-LAT Antibody (ABIN2666055) Images back to top
Antigen
Alternative Name LAT (LAT Antibody Abstract)
Background LAT is a transmembrane molecule that mediates signaling following the engagement of a number of cell surface receptors including TCR during mature T cell activation, pre-TCR during T cell development, Fc RIII on NK cells, and FcεRI on mast cells.LAT is multiply phosphorylated on tyrosines by ZAP-70 and Syk, which leads to downstream effects that include release of intracellular calcium, PKC activation, MAPK activation and cytoskeletal reorganization.Palmitoylation of LAT is required for its localization to lipid rafts and efficient phosphorylation.
Research Area Signaling, Adaptive Immunity
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway

Application Details

Product Details anti-LAT Antibody Target Details LAT Handling References for anti-LAT Antibody (ABIN2666055) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-LAT Antibody Target Details LAT Application Details References for anti-LAT Antibody (ABIN2666055) Images back to top
Concentration 0.5 mg/mL
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store between 2°C and 8°C

References for anti-LAT Antibody (ABIN2666055)

Product Details anti-LAT Antibody Target Details LAT Application Details Handling Images back to top
Background publications

Dorn, Kuhn, Bungartz, Stiller, Bauer, Ellwart, Peters, Scharffetter-Kochanek, Semmrich, Laschinger, Holzmann, Klinkert, Straten, Køllgaard, Sixt, Brakebusch: "RhoH is important for positive thymocyte selection and T-cell receptor signaling." in: Blood, Vol. 109, Issue 6, pp. 2346-55, 2007

Sloan, Han, Sandifer, Stewart, Hinz, Yoon, Johnson, Spear, Jerome: "Inhibition of TCR signaling by herpes simplex virus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 3, pp. 1825-33, 2006

Zhang, Sloan-Lancaster, Kitchen, Trible, Samelson: "LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation." in: Cell, Vol. 92, Issue 1, pp. 83-92, 1998

Weber, Orstavik, Torgersen, Danbolt, Berg, Ryan, Taskén, Imboden, Vaage: "Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells." in: The Journal of experimental medicine, Vol. 187, Issue 7, pp. 1157-61, 1998

Images

Product Details anti-LAT Antibody Target Details LAT Application Details Handling References for anti-LAT Antibody (ABIN2666055) back to top
Supplier Images
Western Blotting (WB) image for anti-LAT antibody (Linker For Activation of T Cells) (ABIN2666055) anti-Linker For Activation of T Cells (LAT) antibody