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High expression of LAT1 and ASCT2 (show SLC1A5 ELISA Kits) correlates with metastasis and invasion in esophageal squamous cell carcinoma.
IFT20 (show IFT20 ELISA Kits) is required for the delivery of the intracellular pool of LAT (show ORC3 ELISA Kits) to the immune synapse in naive primary T lymphocytes.
Data show that the palmitoylation mutation of linker for activation of T cells (LAT)attenuated the signal transduction induced by glycosylphosphatidylinositol-anchored CD59 antigen (show CD59 ELISA Kits) in T cells.
HSV-1-encoded Us3 protein interrupted TCR signaling and interleukin-2 (show IL2 ELISA Kits) production by inactivation of the linker for activation of T cells.
Patients with severe aplastic anemia had increased levels of LAT (show ORC3 ELISA Kits) and disturbed Th1 (show TH1L ELISA Kits)-Th2 balance.
LAT (show ORC3 ELISA Kits) is a modulator of CD3zeta (show CD247 ELISA Kits) and ZAP-70 (show ZAP70 ELISA Kits) tyrosine phosphorylation.
mutation of palmitoylation site of LAT (show ORC3 ELISA Kits)-EGFP attenuated the signal transduction of CD59 (show CD59 ELISA Kits) in T cells
findings show that L-type amino acid transporter 1 (show SLC7A5 ELISA Kits) is a major transporter for essential amino acids into activated human T cells
Histone hypoacetylation on LAT (show ORC3 ELISA Kits) promoter could inhibit LAT (show ORC3 ELISA Kits) expression and enhanced Th2 differentiation, while trichostatin A, a histone deacetylase (show HDAC1 ELISA Kits) inhibitor, promoted LAT (show ORC3 ELISA Kits) expression and inhibited Th2 cytokine production
LAT (show ORC3 ELISA Kits) is required to maintain calcium homeostasis in T cells.
IFT20 (show IFT20 ELISA Kits) is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes.
miR (show MLXIP ELISA Kits)-155 regulates the delicate balance between PAK1 (show PAK1 ELISA Kits)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.
provide evidence that CD28 (show CD28 ELISA Kits) and the TCR complex regulate NF-kappaB (show NFKB1 ELISA Kits) via different signaling modules of GRB-2 (show GRB2 ELISA Kits)/VAV1 (show VAV1 ELISA Kits) and LAT/ADAP (show APP ELISA Kits) pathways respectively.
The result indicate that LAT-PLCg1 (show PLCG1 ELISA Kits) interaction is important for controlling IL-6 (show IL6 ELISA Kits) production by T cells and demonstrate a critical role of IL-6 (show IL6 ELISA Kits) in the development of the lymphoproliferative syndrome.
low level of LAT-PLC-gamma1 (show PLCG1 ELISA Kits) interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT and PLCgamma1 (show PLCG1 ELISA Kits) in Dow2-induced anergic T cells. The novel CD3 (show CD3E ELISA Kits)-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
Sos1 (show SOS1 ELISA Kits) has distinct roles in acting as a scaffold to oligomerize the adaptor protein LAT, and in guanine nucleotide exchange activity
this analysis identified 65 proteins not associated before with the Zap70 (show ZAP70 ELISA Kits)-Lat-SLP-76 (show LCP2 ELISA Kits) network and thus should provide cues for future functional experiments.
Data suggest that transmembrane adaptor protein LAT-PLCgamma1 (Phospholipase C gamma 1 (show PLCG1 ELISA Kits)) signaling may function differently in various subsets of gammadelta T cells.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
linker for activation of T cells
, 36 kDa phospho-tyrosine adapter protein
, 36 kDa phospho-tyrosine adaptor protein
, linker for activation of T cells, transmembrane adaptor
, linker for activation of T-cells family member 1
, linker protein