Browse our anti-LCK (LCK) Antibodies

Full name:
anti-Lymphocyte-Specific Protein tyrosine Kinase Antibodies (LCK)
On www.antibodies-online.com are 453 Lymphocyte-Specific Protein tyrosine Kinase (LCK) Antibodies from 34 different suppliers available. Additionally we are shipping LCK Kits (19) and LCK Proteins (17) and many more products for this protein. A total of 513 LCK products are currently listed.
Synonyms:
Hck-3, LCK, Lck1, Lcktkr, LSK, Lskt, p56, P56LCK, pp58lck, tkl, YT16, zgc:136695

Most Popular Reactivities for anti-LCK (LCK) Antibodies

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anti-Mouse (Murine) LCK Antibodies:

anti-Human LCK Antibodies:

anti-Rat (Rattus) LCK Antibodies:

All available anti-LCK Antibodies

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Top referenced anti-LCK Antibodies

  1. Human Monoclonal LCK Primary Antibody for IP, WB - ABIN967309 : Liu, Abraham: Subtractive cloning of a hybrid human endogenous retrovirus and calbindin gene in the prostate cell line PC3. in Cancer research 1991 (PubMed)
    Show all 9 references for 967309

  2. Human Polyclonal LCK Primary Antibody for FACS, IF - ABIN392101 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 4 references for 392101

  3. Human Polyclonal LCK Primary Antibody for FACS, IHC (p) - ABIN650741 : Paster, Paar, Eckerstorfer, Jakober, Drbal, Schütz, Sonnleitner, Stockinger: Genetically encoded Förster resonance energy transfer sensors for the conformation of the Src family kinase Lck. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)
    Show all 3 references for 650741

  4. Human Polyclonal LCK Primary Antibody for WB - ABIN196860 : Heck, Friedrich, Gack, Lengenfelder, Schmidt, Müller-Fleckenstein, Fleckenstein, Ensser, Biesinger: Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs. in Journal of virology 2006 (PubMed)
    Show all 2 references for 196860

  5. Human Polyclonal LCK Primary Antibody for ELISA, WB - ABIN1533129 : Rouer, Van Huynh, Lavareda de Souza, Lang, Fischer, Benarous: Structure of the human lck gene: differences in genomic organisation within src-related genes affect only N-terminal exons. in Gene 1990 (PubMed)

  6. Human Polyclonal LCK Primary Antibody for IP, IHC - ABIN223217 : Feng, Lucchinetti, Enkavi, Wang, Gehrig, Roschitzki, Schaub, Tajkhorshid, Zaugg, Zaugg: Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria. in American journal of physiology. Cell physiology 2010 (PubMed)

  7. Cow (Bovine) Polyclonal LCK Primary Antibody for WB - ABIN2785755 : Merino, Avila-Flores, Shirai, Moraga, Saito, Mérida: Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)

More Antibodies against LCK Interaction Partners

Mouse (Murine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. We show a striking 65% reduction in cellularity, preferential development of gammadelta versus alphabeta T cells, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck promoter (lck-cre(+) mice)

  2. this work demonstrates a role for constitutive Lck activity in controlling antigen sensitivity

  3. this study defines distinct and complementary requirements for proximal and distal lck promoters during T-cell development

  4. Aurora A (show AURKA Antibodies) inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A (show AURKA Antibodies) is required for maintaining Lck active during T-cell activation.

  5. essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells

  6. Lck-Dlx5 (show DLX5 Antibodies) mice develop T-ALLs that consistently acquire overexpression of Myc (show MYC Antibodies) and activation of Akt (show AKT1 Antibodies).

  7. Lck-CD8 (show CD8A Antibodies) interaction is required for initial CD8 (show CD8A Antibodies) recruitment.

  8. The kinase Itk (show ITK Antibodies) and the adaptor TSAd (show SH2D2A Antibodies) change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.

  9. CD4 (show CD4 Antibodies) is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase (show YES1 Antibodies) p56lck

  10. Study concludes that the intracellular state of Lck Study conclude that the intracellular state of Lck determines the specificity of thymic selection and that Lck association with coreceptor proteins during thymic selection is the mechanism by which MHC restriction is imposed on a randomly generated alphabetaTCR repertoire.

Human Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. this study show that Lck as a major signaling hub of CD147 in T cells

  2. data indicate that HSP65 (show HSPD1 Antibodies) suppresses cholesterol efflux and increases cellular cholesterol content through an Lck-mediated pathway in T cells

  3. LSKlow cells, which are derived from LSK cells in p18 (show CDKN2C Antibodies)(-/-) mice, possess lymphoid differentiation ability and short-term repopulation capability.

  4. These results suggest that PM lipids, including phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, modulate interaction of Lck with its binding partners in the TCR signaling complex and its TCR signaling activities in a spatiotemporally specific manner via its SH2 domain.

  5. this study shows that p56(lck), which is essential for activation of T cells through the T-cell receptor, is also critical for signal transduction through Toll (show TLR4 Antibodies)-like receptors in T cells

  6. Aurora A (show AURKA Antibodies) inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A (show AURKA Antibodies) is required for maintaining Lck active during T-cell activation.

  7. Results demonstrate that Lck represses oxidative phosphorylation through competitive binding with mitochondrial CRIF1 (show GADD45GIP1 Antibodies) in a kinase-independent manner.

  8. introducing bulky side-chains into this patch (GGxxG to GVxxL) impairs the Lck-independent role of CD4 in T cell activation upon TCR engagement of agonist and weak agonist stimulation.

  9. our results support a novel function of nuclear Lck in promoting human leukemic T cell survival through interaction with a tumor suppressor, CRIF1 (show GADD45GIP1 Antibodies)

  10. TSAD (show SH2D2A Antibodies) binds to and co-localizes with Nck (show NCK1 Antibodies). Expression of TSAD (show SH2D2A Antibodies) increases both Nck (show NCK1 Antibodies)-Lck and Nck (show NCK1 Antibodies)-SLP-76 (show LCP2 Antibodies) interaction in T cells.

Pig (Porcine) Lymphocyte-Specific Protein tyrosine Kinase (LCK) interaction partners

  1. LCK gene could be an useful candidate gene in selection for increasing litter size in pigs.

LCK Antigen Profile

Antigen Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.

Alternative names and synonyms associated with LCK

  • lymphocyte-specific protein tyrosine kinase (lck) antibody
  • lymphocyte-specific protein tyrosine kinase (LCK) antibody
  • lymphocyte-specific protein tyrosine kinase (LOC100349102) antibody
  • lymphocyte protein tyrosine kinase (Lck) antibody
  • lymphocyte-specific protein tyrosine kinase (Lck) antibody
  • Hck-3 antibody
  • LCK antibody
  • Lck1 antibody
  • Lcktkr antibody
  • LSK antibody
  • Lskt antibody
  • p56 antibody
  • P56LCK antibody
  • pp58lck antibody
  • tkl antibody
  • YT16 antibody
  • zgc:136695 antibody

Protein level used designations for LCK

lymphocyte protein tyrosine kinase , lymphocyte-specific protein tyrosine kinase , tyrosine-protein kinase Lck-like , leukocyte C-terminal Src kinase , lymphocyte cell-specific protein-tyrosine kinase , proto-oncogene tyrosine-protein kinase LCK , T-lymphocyte specific protein tyrosine kinase p56lck , p56(LSTRA) protein-tyrosine kinase , t cell-specific protein-tyrosine kinase , tyrosine-protein kinase Lck , tyrosine protein kinase , tyrosine-protein kinase LCK , p56-LCK

GENE ID SPECIES
414333 Danio rerio
456715 Pan troglodytes
100216439 Ovis aries
100349102 Oryctolagus cuniculus
100436326 Pongo abelii
100477981 Ailuropoda melanoleuca
16818 Mus musculus
3932 Homo sapiens
396460 Gallus gallus
313050 Rattus norvegicus
478151 Canis lupus familiaris
100233188 Sus scrofa
508890 Bos taurus
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