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A phosphosite within the SH2 Domain of Lck regulates its activation by CD45. A negative feedback loop that responds to signaling events tunes active Lck amounts and TCR sensitivity.
We show a striking 65% reduction in cellularity, preferential development of gammadelta versus alphabeta T cells, and increased expression of IL-7R in the thymus of mice expressing Cre under the proximal lck promoter (lck-cre(+) mice)
this work demonstrates a role for constitutive Lck activity in controlling antigen sensitivity
this study defines distinct and complementary requirements for proximal and distal lck promoters during T-cell development
Aurora A (show AURKA ELISA Kits) inhibition causes delocalized clustering of Lck at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A (show AURKA ELISA Kits) is required for maintaining Lck active during T-cell activation.
essential for thymic development in presence or absence of Cbl, ensuring MHC restriction of T cells
Lck-Dlx5 (show DLX5 ELISA Kits) mice develop T-ALLs that consistently acquire overexpression of Myc (show MYC ELISA Kits) and activation of Akt (show AKT1 ELISA Kits).
Lck-CD8 (show CD8A ELISA Kits) interaction is required for initial CD8 (show CD8A ELISA Kits) recruitment.
The kinase Itk (show ITK ELISA Kits) and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
CD4 (show CD4 ELISA Kits) is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase (show YES1 ELISA Kits) p56lck
The results have revealed a novel splicing homozygous mutation of LCK that may be responsible for the clinical phenotype of HPV infection from latency to invasive carcinoma.
this study show that Lck as a major signaling hub of CD147 in T cells
data indicate that HSP65 (show HSPD1 ELISA Kits) suppresses cholesterol efflux and increases cellular cholesterol content through an Lck-mediated pathway in T cells
LSKlow cells, which are derived from LSK cells in p18 (show CDKN2C ELISA Kits)(-/-) mice, possess lymphoid differentiation ability and short-term repopulation capability.
These results suggest that PM lipids, including phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, modulate interaction of Lck with its binding partners in the TCR signaling complex and its TCR signaling activities in a spatiotemporally specific manner via its SH2 domain.
this study shows that p56(lck), which is essential for activation of T cells through the T-cell receptor, is also critical for signal transduction through Toll (show TLR4 ELISA Kits)-like receptors in T cells
Results demonstrate that Lck represses oxidative phosphorylation through competitive binding with mitochondrial CRIF1 (show GADD45GIP1 ELISA Kits) in a kinase-independent manner.
introducing bulky side-chains into this patch (GGxxG to GVxxL) impairs the Lck-independent role of CD4 in T cell activation upon TCR engagement of agonist and weak agonist stimulation.
LCK gene could be an useful candidate gene in selection for increasing litter size in pigs.
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
lymphocyte protein tyrosine kinase
, lymphocyte-specific protein tyrosine kinase
, tyrosine-protein kinase Lck-like
, leukocyte C-terminal Src kinase
, lymphocyte cell-specific protein-tyrosine kinase
, proto-oncogene tyrosine-protein kinase LCK
, T-lymphocyte specific protein tyrosine kinase p56lck
, p56(LSTRA) protein-tyrosine kinase
, t cell-specific protein-tyrosine kinase
, tyrosine-protein kinase Lck
, tyrosine protein kinase
, tyrosine-protein kinase LCK