Browse our anti-LCP2 (LCP2) Antibodies

On www.antibodies-online.com are 155 Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) Antibodies from 24 different suppliers available. Additionally we are shipping LCP2 Proteins (9) and LCP2 Kits (4) and many more products for this protein. A total of 177 LCP2 products are currently listed.
Synonyms:
AI323664, BB161688, SLP-76, Slp76, twm
list all antibodies Gene Name GeneID UniProt
LCP2 16822 Q60787
LCP2 155918  
LCP2 3937 Q13094

Most Popular Reactivities for anti-LCP2 (LCP2) Antibodies

anti-Mouse (Murine) LCP2 Antibodies:

anti-Rat (Rattus) LCP2 Antibodies:

anti-Human LCP2 Antibodies:

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More Antibodies against LCP2 Interaction Partners

Mouse (Murine) Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

  1. Biochemical analyses revealed that mutant T cells were hypersensitive to TCR stimulation. Indeed, phosphorylation of several signaling proteins, including SLP76 itself, phospholipase Cgamma1 and the protein kinases AKT (show AKT1 Antibodies) and ERK1/2 (show MAPK1/3 Antibodies), was increased

  2. slp-76 contributes to the regulation of the tissue distribution, PLZF (show ZBTB16 Antibodies), and cytokine expression of iNKT cells via ADAP (show APP Antibodies)-dependent and -independent mechanisms.

  3. findings identify ACK1 (show TNK2 Antibodies) as a novel SLP-76-associated protein-tyrosine kinase (show YES1 Antibodies) that modulates early activation events in T cells.

  4. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (show RANGAP1 Antibodies) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (show NFATC1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) nuclear entry in T cells

  5. these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice

  6. Data show that a splice variant of SLP-76 signal transducing adaptor protein (SLP-76 or Lcp2) reduced the amount of SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees.

  7. this analysis identified 65 proteins not associated before with the Zap70 (show ZAP70 Antibodies)-Lat (show LAT Antibodies)-SLP-76 network and thus should provide cues for future functional experiments.

  8. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1 (show PRAM1 Antibodies)/SKAP-HOM (show SKAP2 Antibodies) and SLP-76/Vav (show VAV1 Antibodies)/PLCgamma2 (show PLCG2 Antibodies) signaling hubs may be critical for Yersinia survival.

  9. analysis of a costimulatory mechanism by which CXCL12 (show CXCL12 Antibodies) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  10. Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI (show FCER1A Antibodies) and the IL-3 (show IL-3 Antibodies) receptor.

Human Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) interaction partners

  1. These data are consistent with a model in which bivalent recruitment of a GADS (show GRAP2 Antibodies)/SLP-76 complex is required for costimulation by CD6 (show CD6 Antibodies).

  2. LAT (show ORC3 Antibodies) and SLP-76 are randomly dispersed throughout the clusters that form upon T cell receptor engagement.

  3. SLP76 is ectopically expressed in chronic lymphocytic leukemia cells where it plays a role in B-cell receptor signaling.

  4. findings identify ACK1 (show TNK2 Antibodies) as a novel SLP-76-associated protein-tyrosine kinase (show EPHA8 Antibodies) that modulates early activation events in T cells.

  5. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  6. TSAD (show SH2D2A Antibodies) binds to and co-localizes with Nck (show NCK1 Antibodies). Expression of TSAD (show SH2D2A Antibodies) increases both Nck (show NCK1 Antibodies)-Lck (show LCK Antibodies) and Nck (show NCK1 Antibodies)-SLP-76 interaction in T cells.

  7. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 (show RANGAP1 Antibodies) of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (show NFATC1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) nuclear entry in T cells

  8. SLP-76 N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor signaling

  9. analysis of a costimulatory mechanism by which CXCL12 (show CXCL12 Antibodies) and antigen converge at SLP-76 microcluster formation to enhance T cell responses

  10. Multipoint binding of SLP-76 to ADAP (show FYB Antibodies) facilitates the assembly of SLP-76 microclusters.

LCP2 Antigen Profile

Antigen Summary

SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

Alternative names and synonyms associated with LCP2

  • lymphocyte cytosolic protein 2 (Lcp2) antibody
  • lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2) antibody
  • AI323664 antibody
  • BB161688 antibody
  • SLP-76 antibody
  • Slp76 antibody
  • twm antibody

Protein level used designations for LCP2

SH2 domain-containing leukocyte protein of 76 kDa , SLP-76 tyrosine phosphoprotein , lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD) , 76 kDa tyrosine phosphoprotein , SH2 domain-containing leukocyte protein of 76kD , lymphocyte cytosolic protein 2 , tyrosine phosphoprotein slp-76

GENE ID SPECIES
16822 Mus musculus
155918 Rattus norvegicus
3937 Homo sapiens
100511843 Sus scrofa
489126 Canis lupus familiaris
513244 Bos taurus
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