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Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review)
Data show that Bruton tyrosine kinase (BTK (show BTK Proteins))inhibitor Ibrutinib augments MALT lymphoma associated translocation protein (MALT1) inhibition by S-Mepazine in CD79 antigen mutant activated B cell-subtype (ABC (show ABCB6 Proteins)) of diffuse large B cell lymphoma (DLBCL).
TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
MALT1 protease activity has a central role in keratinocyte immunity
Data show that caspase recruitment domain-containing protein 11 (show CARD11 Proteins)/B-cell CLL/lymphoma 10 (show BCL10 Proteins)/mucosa-associated lymphoid tissue lymphoma translocation gene 1 signaling drives lymphoproliferation (show FAS Proteins) through NF-kappa B (show NFKB1 Proteins) and c-Jun N-terminal kinase activation.
MALT1-dependent NF-kappaB (show NFKB1 Proteins) activation is crucial for the development of EGFR (show EGFR Proteins)-associated solid-tumor progression
Backbone Assignment of the MALT1 Paracaspase by Solution NMR.
The MALT1-mediated HOIL-1 (show RBCK1 Proteins) cleavage provides a gain-of-function mechanism that is involved in the negative feedback regulation of NF-kappaB (show NFKB1 Proteins) signaling.
The MALT1 is a key player in the activation of the NF-kappa B (show NFKB1 Proteins) upon antigen receptor stimulation and lymphocyte activation.
An overview of the present understanding of MALT1's function is presented. [review]
By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the canonical NF-kappaB (show NFKB1 Proteins) pathway.
Results demonstrate that MALT1 protease activity plays key roles in both innate and adaptive immune responses, and in regulating immune homeostasis in vivo.
data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK (show CHUK Proteins) complexes, thereby directing platelet signals to the NF-kappaB (show NFKB1 Proteins) pathway.
Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.
These results reveal distinct threshold and modulatory functions of Malt1 that differentially control lymphocyte differentiation and activation pathways.
data suggest that Carma1 and MALT1 play previously unappreciated roles in the activation of mTOR signaling in T cells after engagement of the TCR.
Trehalose 6,6'-dimycolate-induced Mincle (show CLEC4E Proteins) expression is dependent on Dectin-3-mediated NF-kappaB (show NFKB1 Proteins) activation through the CARD9 (show CARD9 Proteins)-BCL10 (show BCL10 Proteins)-MALT1 complex.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
mucosa associated lymphoid tissue lymphoma translocation gene 1
, mucosa associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1-like
, MALT associated translocation
, MALT lymphoma-associated translocation
, MALT-lymphoma associated translocation
, caspase-like protein
, mucosa-associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog