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Thrombin (show F2 Proteins)-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD (show CYLD Proteins) cleavage.
Authors utilized transcriptomic data and experimental evidences to prove that miR (show MLXIP Proteins)-181d was a novel regulator of NFkappaB (show NFKB1 Proteins) signaling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES (show ME1 Proteins) genes.
Taken together, this present study indicates that miR (show MLXIP Proteins)-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies.
These results demonstrate a key role for the proteolytic activity of MALT1 in PEL, and provide a rationale for the pharmacological targeting of MALT1 in PEL therapy.
MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14 (show CARD14 Proteins)-induced cytokine and chemokine (show CCL1 Proteins) expression in human primary keratinocytes.
results unveil HOIL1 (show RBCK1 Proteins) as a negative regulator of lymphocyte activation cleaved by MALT1.
CARD14 (show CARD14 Proteins)/MALT1-mediated signaling in keratinocytes has a role in psoriasis [review]
Psoriasis mutations disrupt CARD14 (show CARD14 Proteins) autoinhibition promoting BCL10 (show BCL10 Proteins)-MALT1-dependent NF-kappaB (show NFKB1 Proteins) activation
Studies indicate that t(11;18)(q21;q21) translocation involves MALT1 (MALT lymphoma translocation protein 1) gene.
Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review)
Data show that inhibition of the protease activity of MALT1 might be a strategy to treat inflammatory bowel disease and the NLRP3 (show NLRP3 Proteins) inflammasome and NF-kappaB (show NFKB1 Proteins) activation are critical components in MALT1 signaling cascades in this disease model.
MALT1 function is required in B cells for germinal center formation.
Studies indicate an important role for mucosa associated lymphoid tissue lymphoma translocation gene 1 protein (MALT1) in the development of experimental autoimmune encephalomyelitis (EAE)
TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
MALT1-dependent NF-kappaB (show NFKB1 Proteins) activation is crucial for the development of EGFR (show EGFR Proteins)-associated solid-tumor progression
By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the canonical NF-kappaB (show NFKB1 Proteins) pathway.
Results demonstrate that MALT1 protease activity plays key roles in both innate and adaptive immune responses, and in regulating immune homeostasis in vivo.
data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK (show CHUK Proteins) complexes, thereby directing platelet signals to the NF-kappaB (show NFKB1 Proteins) pathway.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
mucosa associated lymphoid tissue lymphoma translocation gene 1
, mucosa associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1-like
, MALT associated translocation
, MALT lymphoma-associated translocation
, MALT-lymphoma associated translocation
, caspase-like protein
, mucosa-associated lymphoid tissue lymphoma translocation protein 1
, mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog