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anti-Human Mu Opioid Receptor Antibodies:
anti-Rat (Rattus) Mu Opioid Receptor Antibodies:
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We found a C-rich element (CRE) in mu-opioid receptor (MOR (show OPRM1 Antibodies)) 3'-untranslated region (UTR (show UTS2R Antibodies)) to which poly (rC) binding protein 1 (PCBP1 (show PCBP1 Antibodies)) binds, resulting in MOR (show OPRM1 Antibodies) mRNA stabilization. AUF1 (show HNRNPD Antibodies) phosphorylation also led to an increased interaction with PCBP1 (show PCBP1 Antibodies).
rs1799971 of OPRM1 (show OPRM1 Antibodies) contributes to mechanisms of addiction liability that are shared across different addictive substances.
Initial studies in neonates with in utero opiate exposure demonstrated that single-nucleotide polymorphisms in OPRM1 (show OPRM1 Antibodies) gene were associated with improved outcomes in infants with Neonatal abstinence syndrome.
OPRM1 (show OPRM1 Antibodies) might be used in near future to customize the opioid therapy, avoiding not only opioid side effects
The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1 (show OPRM1 Antibodies), OPRK1 (show OPRK1 Antibodies), OPRD1 (show OPRD1 Antibodies)) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone.
OPRM1 (show OPRM1 Antibodies) A118G genotype was associated with alcohol self administration and subjective measures of alcohol sensitivity.
This study demonstrated that brain regions particularly related to the somatosensory component of pain processing are modulated by variations in OPRM1 (show OPRM1 Antibodies).
siRNA-loaded RVG exosomes significantly reduced MOR mRNA and protein levels. Surprisingly, MOR siRNA delivered by the RVG exosomes strongly inhibited morphine relapse via the down-regulation of MOR expression
No association has been found between the OPRM1 (show OPRM1 Antibodies) A118G SNP and pain perception in Chinese cancer patients.
result indicated that Caucasians carrying the G allele (AG + GG) of the A118G polymorphism in the mu-opioid receptor (show OPRM1 Antibodies) gene were more likely to be addicted to smoking compared with those with the AA homozygote
This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene.
micro opioid receptor isoform hMOR-1A2
, mu opiate receptor
, mu opioid receptor hMOR-1a
, mu-type opioid receptor