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anti-Human ORAI1 Antibodies:
anti-Mouse (Murine) ORAI1 Antibodies:
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Human Polyclonal ORAI1 Primary Antibody for IHC (p), WB - ABIN2475964
Weston, Lawrence: An educational strategy for teaching psychosocial pediatrics. in Southern medical journal 1975
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Human Polyclonal ORAI1 Primary Antibody for ELISA, WB - ABIN449577
Li, Lu, Xu, Xie, Chen, Xu: Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation. in The Journal of biological chemistry 2007
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Human Polyclonal ORAI1 Primary Antibody for IHC, ELISA - ABIN1002945
Soboloff, Spassova, Dziadek, Gill: Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication. in Biochimica et biophysica acta 2006
Show all 2 Pubmed References
Human Polyclonal ORAI1 Primary Antibody for IHC, ELISA - ABIN1002944
Feske, Gwack, Prakriya, Srikanth, Puppel, Tanasa, Hogan, Lewis, Daly, Rao: A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. in Nature 2006
Show all 2 Pubmed References
Human Monoclonal ORAI1 Primary Antibody for ELISA, ICC - ABIN4341596
Ávila-Medina, Calderón-Sánchez, González-Rodríguez, Monje-Quiroga, Rosado, Castellano, Ordóñez, Smani: Orai1 and TRPC1 Proteins Co-localize with CaV1.2 Channels to Form a Signal Complex in Vascular Smooth Muscle Cells. in The Journal of biological chemistry 2016
Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function.
The Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway.
STIM1 (show STIM1 Antibodies) and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.
Healthy individuals and patients with urolithiasis in the Russian population who have the GG genotype and/or the G allele of the polymorphism of the ORAI1 gene (rs7135617) represent risk groups for the formation of calcium oxalate stones.
Orai1 expression is a predictor of 5-Fluorouracil sensitivity for hepatocarcinoma treatment.
Store-operated calcium entry via Orai1 in mesangial cells negatively regulates the TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling pathway.
RASSF4 (show RIN2 Antibodies) controls store operated calcium entry and endoplasmic reticulum-plasma membrane junctions through ARF6 (show ARF6 Antibodies)-dependent regulation of PM PI(4,5)P2 levels, pivotal for a variety of physiological processes.
findings provide evidence for a role for Orai1 and Orai2 (show ORAI2 Antibodies), in SOCE and migration in the human HL60 promyeloblastic cell line
findings demonstrate that Ca2 (show CA2 Antibodies)+ influx via store-operated CRAC channels is essential for CaCC (show CLCA1 Antibodies) activation, chloride secretion, and sweat production in humans and mice.
F. vulgare fruits extract and its hexane fraction strongly blocked ORAI1 currents and tyrosinase (show TYR Antibodies) activity and significantly inhibited UV-induced melanogenesis
Aptamer Y1 binds to Orai1 and inhibits Ca2 (show CA2 Antibodies)+ influx into antigen-activated mast cells
Elevated Orai1 and STIM1 (show STIM1 Antibodies) expressions upregulate MACC1 (show MACC1 Antibodies) expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer.
Orai1 expression was higher in colorectal cancer (CRC (show CALR Antibodies)) tissues than adjacent non-cancerous tissues; increased expression of Orai1 was observed in invasive CRC (show CALR Antibodies) cell lines and ectopic expression of Orai1 enhanced cell proliferation and inhibited apoptosis; the Akt (show AKT1 Antibodies)/GSK3beta (show GSK3b Antibodies) pathway contributed to Orai1 effects in CRC (show CALR Antibodies) cells, and Orai1 was a direct target of miR (show MLXIP Antibodies)-519
Store-operated calcium entry via Orai1 (show TMEM132A Antibodies) in mesangial cells negatively regulates the TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling pathway.
Orai1 (show TMEM132A Antibodies) enhances muscle endurance by promoting fatigue-resistant type I fiber content
Mouse embryos deficient in Orai1 (show TMEM132A Antibodies), Klf2 (show KLF2 Antibodies), or Klf4 (show KLF4 Antibodies) showed a significantly reduced lymphatic density and impaired lymphatic development.
Store operated calcium entry negatively regulates the Smad1 (show SMAD1 Antibodies) signaling pathway and inhibits Col (show HDAC1 Antibodies) IV protein production in glomerular mesangial cells.
F. vulgare fruits extract and its hexane fraction strongly blocked ORAI1 (show TMEM132A Antibodies) currents and tyrosinase (show TYR Antibodies) activity and significantly inhibited UV-induced melanogenesis
mice lacking acinar Orai1 (show TMEM132A Antibodies) exhibited intestinal bacterial outgrowth and dysbiosis, ultimately causing systemic translocation, inflammation, and death.
these data indicate for the first time a functional interaction between Orai1 (show TMEM132A Antibodies), TRPC1 (show TRPC1 Antibodies), and CaV1.2 (show CACNA1C Antibodies) channels in Vascular Smooth Muscle Cells, confirming that upon agonist stimulation, vessel contraction involves Ca(2 (show CA2 Antibodies)+) entry due to co-activation of Orai1 (show TMEM132A Antibodies)- and TRPC1 (show TRPC1 Antibodies)-dependent store-operated Ca(2 (show CA2 Antibodies)+) channels and L-type Ca(2 (show CA2 Antibodies)+) channels.
reveal that Orai1 (show TMEM132A Antibodies)(-/-) male mice are sterile and have severe defects in spermatogenesis, with prominent deficiencies in mid- to late-stage elongating spermatid development
In Dicer (show DICER1 Antibodies)-deficient mice Orai1 (show TMEM132A Antibodies) was down-regulated at mRNA and protein level in CD4 (show CD4 Antibodies)+ T cells.
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
ORAI calcium release-activated calcium modulator 1
, calcium release-activated calcium channel protein 1
, protein orai-1
, transmembrane protein 142A
, protein orai-2
, transmembrane protein 142B
, calcium release-activated calcium modulator 1
, calcium release-activated calcium channel 1