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These findings highlight a hitherto unexplored and novel role for Cbl (show CBL Proteins) and PI3K in modulating the osteogenic response of periosteal cells during the early stages of fracture repair.
Data indicate alpha-P85 (show ECM1 Proteins) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR (show EGFR Proteins)) expression and cell malignant transformation via nucleolin (show NCL Proteins)-dependent mechanism.
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
insulin (show INS Proteins) and aPC (show APC Proteins) converge on a common spliced-X-box binding protein-1 (show XBP1 Proteins) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
Data demonstrated a novel role of Pik3r1 that was independent of the regulatory function of phosphoinositide 3-kinase in mediating the metabolic action of glucocorticoids. Glucocorticoids increased hormone sensitive lipase phosphorylation, but not Plin1 phosphorylation, in adipose tissue-specific Pik3r1-null (AKO) mice.
Collectively, these findings showed that SA suppressed mammary gland development of pubertal mice, which was coincident with the SA-inhibited HC11 proliferation, and was associated with inhibition of PI3K/Akt signaling pathway through activation of GPR120.
suggest that small-bowel resection reduces p85alpha and TP53 (show TP53 Proteins), which increases survivin (show BIRC5 Proteins) and intestinal epithelial cell expansion during therapeutic adaptation in patients with short bowel syndrome
These results indicate that there is a tissue-specific regulation of IGF-1 (show IGF1 Proteins)/PI3K/Akt (show AKT1 Proteins) during normal aging and upon dietary restriction to help maintain the metabolic status of these tissues at those phases of animal's lifespan.
Uncarboxylated osteocalcin (show BGLAP Proteins) inhibits high glucose-induced reactive oxygen species production and stimulates osteoblastic differentiation by inhibiting the activation of PI3K/Akt (show AKT1 Proteins) in MC3T3-E1 cells.
miR-130a plays a critical role in attenuation of cardiac dysfunction and remodeling after myocardial infarction. The mechanisms involve activation of PI3K/Akt signaling via suppression of PTEN expression.
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity).
PI3-kinase regulatory subunit alpha
, PI3-kinase subunit p85-alpha
, PI3K regulatory subunit alpha
, phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
, phosphatidylinositol 3-kinase regulatory subunit alpha
, ptdIns-3-kinase regulatory subunit alpha
, ptdIns-3-kinase regulatory subunit p85-alpha