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Browse our anti-PKB (PKB) Antibodies

Full name:
anti-Protein Kinase B Antibodies (PKB)
On are 0 Protein Kinase B (PKB) Antibodies from different suppliers available. Additionally we are shipping PKB Kits (24) and many more products for this protein. A total of 24 PKB products are currently listed.
list all antibodies Gene Name GeneID UniProt
Anti-Human PKB PKB 2185 Q14289
Anti-Mouse PKB PKB 11651 P31750
Anti-Rat PKB PKB 24185 P47196

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More Antibodies against PKB Interaction Partners

Human Protein Kinase B (PKB) interaction partners

  1. Studies suggest that PYK2 (show PTK2B Antibodies) is a common downstream effector of ErbB (show EGFR Antibodies) and IL8 (show IL8 Antibodies) receptors, and that PYK2 (show PTK2B Antibodies) integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  2. Pyk2 (show PTK2B Antibodies) is a key downstream signaling molecules of CCR7 (show CCR7 Antibodies) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  3. Phosphoproteomic analysis identifies FAK2 (show PTK2B Antibodies) as a potential therapeutic target for tamoxifen resistance in breast cancer.

  4. Pyk2 (show PTK2B Antibodies)-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Antibodies).

  5. Src (show SRC Antibodies) has a role in priming Pyk2 (show PTK2B Antibodies) (but not FAK (show PTK2 Antibodies)) phosphorylation and subsequent activation downstream of integrins

  6. Data strongly suggest that chemokine-stimulated associations between Vav1, SLP-76, and ADAP facilitate Rac1 activation and alpha4beta1-mediated adhesion, whereas Pyk2 opposes this adhesion by limiting Rac1 activation.

  7. FAK (show PTK2 Antibodies) and PYK2 (show PTK2B Antibodies) functioned redundantly to promote the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway by phosphorylating GSK3beta (show GSK3b Antibodies)(Y216) to reinforce pathway output-beta-catenin (show CTNNB1 Antibodies) accumulation and intestinal tumorigenesis.

  8. This study identified Pyk2 (show PTK2B Antibodies) as a cellular component required for the intracellular trafficking of HPV16 during infection.

  9. These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via reactive oxygen species-alphavbeta3 integrin-FAK (show PTK2 Antibodies)/Pyk2 (show PTK2B Antibodies) signaling pathways.

  10. data suggest a novel role for FAK (show PTK2 Antibodies) in GPVI (show GP6 Antibodies)-dependent ROS (show ROS1 Antibodies) formation and platelet activation and elucidate a proximal signaling role for FAK (show PTK2 Antibodies) within the GPVI (show GP6 Antibodies) pathway.

Mouse (Murine) Protein Kinase B (PKB) interaction partners

  1. Data show that RNA silencing of CCN family member 1 (show CYR61 Antibodies) protein (CCN1 (show CCNA2 Antibodies)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT (show AKT1 Antibodies) protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).

  2. rescued the hepatic regenerative capability in Akt1 (show AKT1 Antibodies)-deficient and Akt2 (show AKT2 Antibodies)-deficient mice

  3. While combined Akt1 and Akt3 deletion in adult mice is tolerated, combined Akt1 and Akt2 deletion induced rapid mortality involving glucose metabolism problems. ACT1-null mice are not resistant to diethylnitrosamine hepatocarcinogenesis.

  4. ShRNA knockdown (kd) of AKT1 (show AKT1 Antibodies) prevents phosphorylation and subsequent degradation of nuclear lamins.

  5. Our study suggests that Ab25-35 induces autophagy and the PI3K/AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies)/p70S6K (show RPS6KB1 Antibodies) pathway is involved in the process, which improves our understanding of the pathogenesis of Alzheimer's disease and provides an additional model for AD research

  6. We propose that targeted inhibition of PTEN (show PTEN Antibodies) and hyperactivation of AKT (show AKT1 Antibodies) triggers a checkpoint for the elimination of autoreactive B cells and represents a new strategy to overcome drug resistance in human pre-B acute lymphoblastic leukemia .

  7. Expression of activated AKT1 (show AKT1 Antibodies) resulted in highly metastatic melanomas with lung and brain metastases.

  8. results support the hypothesis that inhibiting dephosphorylation of pAKT (show AKT1 Antibodies) may be one of the pathways by which LAT (show LAT Antibodies) protects cells against apoptosis

  9. androstenedione administration increased Akt1 (show AKT1 Antibodies) and PKC zeta (show PRKCZ Antibodies) phosphorylation in the muscle tissue of C57BL6 mice.

  10. Akt (show AKT1 Antibodies)-dependent Girdin (show CCDC88A Antibodies) phosphorylation regulates repair processes after acute myocardial infarction.

Pig (Porcine) Protein Kinase B (PKB) interaction partners

  1. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

  2. Host PI3K and Akt1 (show AKT1 Antibodies) play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

  3. Activity of AKT (show AKT1 Antibodies) is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  4. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  5. findings show that megalin (show LRP2 Antibodies) is the sensor that determines whether cells will be protected or injured by albumin (show ALB Antibodies); it binds protein kinase B (PKB (show AKT1 Antibodies)) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB (show AKT1 Antibodies) in the luminal plasma membrane [

  6. protein kinase B (PKB/Akt (show AKT1 Antibodies))was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

  7. Akt (show AKT1 Antibodies) signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.

  8. in VSMCs exposed to hyperglycemia, IGF-I (show IGF1 Antibodies) stimulation of Shc (show SHC1 Antibodies) facilitates the transfer of Grb2 (show GRB2 Antibodies) to p85 (show ARHGEF7 Antibodies) resulting in enhanced PI3K activation and AKT (show AKT1 Antibodies) phosphorylation leading to enhanced cell proliferation and migration

  9. There was no correlation of infarct size with expression or phosphorylation of AKT (show AKT1 Antibodies) in ischemic postconditioning.

Goat Protein Kinase B (PKB) interaction partners

  1. Exogenous AKT (show AKT1 Antibodies) was transcribed, and AKT (show AKT1 Antibodies) was overexpressed, inducing the phosphorylation of p70S6K (show RPS6KB1 Antibodies) (Thr389) and 4E-BP1 (show EIF4EBP1 Antibodies) (Thr37/46) in goat fetal fibroblasts.

Cow (Bovine) Protein Kinase B (PKB) interaction partners

  1. These results demonstrate that activation of AKT (show AKT1 Antibodies) is required for gonadotropin regulation of CTNNB1 (show CTNNB1 Antibodies) accumulation and subsequent ovarian E2 production.

  2. Caveolin-1 (show CAV1 Antibodies) scaffolding domain residue phenylalanine 92 modulates Akt (show AKT1 Antibodies) signaling

  3. TG2 (show TGM2 Antibodies) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT (show AKT1 Antibodies) signaling, likely via its serotonylation.

  4. results suggest that PI3K-Akt (show AKT1 Antibodies) activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (show GSK3b Antibodies), and NF-kappaB (show NFKB1 Antibodies).

  5. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (show NOX1 Antibodies), reactive oxygen species, and PI3-kinase (show PIK3CA Antibodies) in stimulated NO release.

  6. PI3K/Akt (show AKT1 Antibodies) and p53 (show TP53 Antibodies) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  7. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (show AKT1 Antibodies), mTOR (show FRAP1 Antibodies), p70S6K (show RPS6KB1 Antibodies), and ERK1/2 (show MAPK1/3 Antibodies).

  8. Gab1 (show GAB1 Antibodies) tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B (show AKT1 Antibodies) and endothelial nitric-oxide synthase (show NOS3 Antibodies) activation in endothelial cells

  9. Losartan metabolite stimulates eNOS (show NOS3 Antibodies) phosphorylation and suppresses tumor necrosis factor alpha (show TNF Antibodies)-induced endothelial cell apoptosis by activating AKT1 (show AKT1 Antibodies).

  10. prostaglandin F2alpha phosphorylates TSC2 (show TSC2 Antibodies) and activates mTOR (show FRAP1 Antibodies) and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner

PKB Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PKB

  • protein tyrosine kinase 2 beta (PTK2B) antibody
  • thymoma viral proto-oncogene 1 (Akt1) antibody
  • v-akt murine thymoma viral oncogene homolog 1 (Akt1) antibody
  • v-akt murine thymoma viral oncogene homolog 1 (AKT1) antibody
  • v-akt murine thymoma viral oncogene homolog 2 (AKT2) antibody
  • AKT antibody
  • CADTK antibody
  • CAKB antibody
  • FADK2 antibody
  • FAK2 antibody
  • PKB antibody
  • PKB/Akt antibody
  • PKBalpha antibody
  • PTK antibody
  • PYK2 antibody
  • Rac antibody
  • RAFTK antibody

Protein level used designations for anti-Protein Kinase B (PKB) Antibodies

CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , AKT1 kinase , PKB alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , protein kinase B alpha , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , RAC protein kinase alpha RAC-PK alpha , murine thymoma viral (v-akt) oncogene homolog 1 , thymoma viral proto-oncogene 1 , v-akt murine thymoma viral oncogene-like 1 , v-akt murine thymoma viral oncogene-like protein 1 , RAC-beta serine/threonine-protein kinase

2185 Homo sapiens
11651 Mus musculus
24185 Rattus norvegicus
100126861 Sus scrofa
100860904 Capra hircus
280991 Bos taurus
100294652 Ovis aries
449021 Canis lupus familiaris
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