Browse our anti-PKB (PKB) Antibodies

Full name:
anti-Protein Kinase B Antibodies (PKB)
On www.antibodies-online.com are 8 Protein Kinase B (PKB) Antibodies from 5 different suppliers available. Additionally we are shipping PKB Kits (24) and many more products for this protein. A total of 32 PKB products are currently listed.
Synonyms:
AKT, CADTK, CAKB, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, PYK2, Rac, RAFTK

Most Popular Reactivities for anti-PKB (PKB) Antibodies

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anti-Human PKB Antibodies:

anti-Mouse (Murine) PKB Antibodies:

anti-Rat (Rattus) PKB Antibodies:

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Top referenced anti-PKB Antibodies

  1. Mouse (Murine) Polyclonal PKB Primary Antibody for IHC, WB - ABIN350718 : Anai, Shojima, Katagiri, Ogihara, Sakoda, Onishi, Ono, Fujishiro, Fukushima, Horike, Viana, Kikuchi, Noguchi, Takahashi, Takata, Oka, Uchijima, Kurihara, Asano: A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for 350718

More Antibodies against PKB Interaction Partners

Human Protein Kinase B (PKB) interaction partners

  1. Our findings suggest that Pyk2 (show PTK2B Antibodies) plays an important role in the coordination of stabilization of beta-catenin (show CTNNB1 Antibodies) in the crosstalk between Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) and Wnt (show WNT2 Antibodies)/Ca(2 (show CA2 Antibodies)+) signaling pathways upon Wnt3a (show WNT3A Antibodies) stimulation in differentiating hNPCs.

  2. STIM1 (show STIM1 Antibodies)-induced Ca(2 (show CA2 Antibodies)+) signaling activates Pyk2 (show PTK2B Antibodies) to inhibit the interaction of VE-PTP (show PTPRB Antibodies) and VE-cadherin (show CDH5 Antibodies) and hence increase endothelial permeability.

  3. Ascites and CCL18 (show CCL18 Antibodies) stimulate the phosphorylation and expression of Pyk2 (show PTK2B Antibodies), which positively regulates ascites-induced ovarian cancer cell migration.

  4. We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (show PIK3CA Antibodies)-Akt/PKB (show AKT1 Antibodies) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.

  5. PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.

  6. Studies suggest that PYK2 (show PTK2B Antibodies) is a common downstream effector of ErbB (show EGFR Antibodies) and IL8 (show IL8 Antibodies) receptors, and that PYK2 (show PTK2B Antibodies) integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  7. Pyk2 (show PTK2B Antibodies) is a key downstream signaling molecules of CCR7 (show CCR7 Antibodies) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  8. Phosphoproteomic analysis identifies FAK2 (show PTK2B Antibodies) as a potential therapeutic target for tamoxifen resistance in breast cancer.

  9. Pyk2 (show PTK2B Antibodies)-focal adhesion targeting domain interacts with and binds to leupaxin (show LPXN Antibodies).

  10. Src (show SRC Antibodies) has a role in priming Pyk2 (show PTK2B Antibodies) (but not FAK (show PTK2 Antibodies)) phosphorylation and subsequent activation downstream of integrins

Mouse (Murine) Protein Kinase B (PKB) interaction partners

  1. TSC1 (show TSC1 Antibodies)/TSC2 (show TSC2 Antibodies) complex upregulation of OPN (show SPP1 Antibodies) expression is mediated by transcription factor SOX9 (show SOX9 Antibodies) in an mTOR (show FRAP1 Antibodies)-independent manner. Moreover, ablation of OPN (show SPP1 Antibodies) by deficient TSC1 (show TSC1 Antibodies)/TSC2 (show TSC2 Antibodies) complex contributed to inactivation of AKT (show AKT1 Antibodies) in TSC (show SLC12A3 Antibodies) cells

  2. Our results suggest that increasing Akt (show AKT1 Antibodies)/ NF-kappaB (show NFKB1 Antibodies) is a crucial mediator of skin aging, which can increase the susceptibility of cell transformation.

  3. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  4. Studies indicate that the Pten (show PTEN Antibodies)+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten (show PTEN Antibodies) is a key regulatory player in the PI3K/PTEN (show PTEN Antibodies)/AKT (show AKT1 Antibodies) pathway.

  5. a simple, linear, four-compartment ordinary differential equation (ODE) model of Akt (show AKT1 Antibodies) activation that tracks both the biochemical state and the physical location of Akt (show AKT1 Antibodies), is reported.

  6. Psgl-1 (show SELPLG Antibodies) deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT (show AKT1 Antibodies) axis.

  7. Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (show HSP90 Antibodies) and the PI3K/AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway in prostate cancer.

  8. Furthermore, Leishmania RNA virus 1-induced TLR-3 (show TLR3 Antibodies) activation promoted parasite persistence by enhancing macrophage survival through Akt (show AKT1 Antibodies) activation in a manner partially dependent on miR (show MLXIP Antibodies)-155.

  9. Collectively, these findings showed that SA suppressed mammary gland development of pubertal mice, which was coincident with the SA-inhibited HC11 (show CCL2 Antibodies) proliferation, and was associated with inhibition of PI3K/Akt (show AKT1 Antibodies) signaling pathway through activation of GPR120 (show O3FAR1 Antibodies).

  10. Findings suggest that atorvastatin attenuates diabetes-associated renal injury by reducing reactive oxygen species (ROS (show ROS1 Antibodies)) generation, RhoA (show RHOA Antibodies) activity and normalizing Akt (show AKT1 Antibodies)/GSK3beta (show GSK3b Antibodies) signaling pathways.

Pig (Porcine) Protein Kinase B (PKB) interaction partners

  1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (show AKT1 Antibodies)-mTOR (show FRAP1 Antibodies)-FOXO1 (show FOXO1 Antibodies) signaling and suppressing the activation of TLR4 (show TLR4 Antibodies) and/or NOD2 (show NOD2 Antibodies) signaling pathways.

  2. Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt (show AKT1 Antibodies) signaling pathway may be involved.

  3. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 (show AKT1 Antibodies) could positively regulate lactose synthesis.

  4. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

  5. Host PI3K and Akt1 (show AKT1 Antibodies) play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

  6. Activity of AKT (show AKT1 Antibodies) is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  7. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  8. findings show that megalin (show LRP2 Antibodies) is the sensor that determines whether cells will be protected or injured by albumin (show ALB Antibodies); it binds protein kinase B (PKB (show AKT1 Antibodies)) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB (show AKT1 Antibodies) in the luminal plasma membrane [

  9. protein kinase B (PKB/Akt (show AKT1 Antibodies))was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

  10. Akt (show AKT1 Antibodies) signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.

Goat Protein Kinase B (PKB) interaction partners

  1. Exogenous AKT (show AKT1 Antibodies) was transcribed, and AKT (show AKT1 Antibodies) was overexpressed, inducing the phosphorylation of p70S6K (show RPS6KB1 Antibodies) (Thr389) and 4E-BP1 (show EIF4EBP1 Antibodies) (Thr37/46) in goat fetal fibroblasts.

Cow (Bovine) Protein Kinase B (PKB) interaction partners

  1. These results demonstrate that activation of AKT (show AKT1 Antibodies) is required for gonadotropin regulation of CTNNB1 (show CTNNB1 Antibodies) accumulation and subsequent ovarian E2 production.

  2. Caveolin-1 (show CAV1 Antibodies) scaffolding domain residue phenylalanine 92 modulates Akt (show AKT1 Antibodies) signaling

  3. TG2 (show TGM2 Antibodies) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT (show AKT1 Antibodies) signaling, likely via its serotonylation.

  4. results suggest that PI3K-Akt (show AKT1 Antibodies) activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (show GSK3b Antibodies), and NF-kappaB (show NFKB1 Antibodies).

  5. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (show NOX1 Antibodies), reactive oxygen species, and PI3-kinase (show PIK3CA Antibodies) in stimulated NO release.

  6. PI3K/Akt (show AKT1 Antibodies) and p53 (show TP53 Antibodies) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  7. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (show AKT1 Antibodies), mTOR (show FRAP1 Antibodies), p70S6K (show RPS6KB1 Antibodies), and ERK1/2 (show MAPK1/3 Antibodies).

  8. Gab1 (show GAB1 Antibodies) tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B (show AKT1 Antibodies) and endothelial nitric-oxide synthase (show NOS3 Antibodies) activation in endothelial cells

  9. Losartan metabolite stimulates eNOS (show NOS3 Antibodies) phosphorylation and suppresses tumor necrosis factor alpha (show TNF Antibodies)-induced endothelial cell apoptosis by activating AKT1 (show AKT1 Antibodies).

  10. prostaglandin F2alpha phosphorylates TSC2 (show TSC2 Antibodies) and activates mTOR (show FRAP1 Antibodies) and ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) signaling in an AKT (show AKT1 Antibodies)-independent manner

PKB Antigen Profile

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PKB

  • protein tyrosine kinase 2 beta (PTK2B) antibody
  • thymoma viral proto-oncogene 1 (Akt1) antibody
  • v-akt murine thymoma viral oncogene homolog 1 (Akt1) antibody
  • v-akt murine thymoma viral oncogene homolog 1 (AKT1) antibody
  • v-akt murine thymoma viral oncogene homolog 2 (AKT2) antibody
  • AKT antibody
  • CADTK antibody
  • CAKB antibody
  • FADK2 antibody
  • FAK2 antibody
  • PKB antibody
  • PKB/Akt antibody
  • PKBalpha antibody
  • PTK antibody
  • PYK2 antibody
  • Rac antibody
  • RAFTK antibody

Protein level used designations for anti-Protein Kinase B (PKB) Antibodies

CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , AKT1 kinase , PKB alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , protein kinase B alpha , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , RAC protein kinase alpha RAC-PK alpha , murine thymoma viral (v-akt) oncogene homolog 1 , thymoma viral proto-oncogene 1 , v-akt murine thymoma viral oncogene-like 1 , v-akt murine thymoma viral oncogene-like protein 1 , RAC-beta serine/threonine-protein kinase

GENE ID SPECIES
2185 Homo sapiens
11651 Mus musculus
24185 Rattus norvegicus
100126861 Sus scrofa
100860904 Capra hircus
280991 Bos taurus
100294652 Ovis aries
449021 Canis lupus familiaris
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