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anti-Human PKC theta Antibodies:
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Human Monoclonal PKC theta Primary Antibody for IHC (f), IF - ABIN967739
Dienz, Hehner, Droge, Schmitz: Synergistic activation of NF-kappa B by functional cooperation between vav and PKCtheta in T lymphocytes. in The Journal of biological chemistry 2000
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Human Monoclonal PKC theta Primary Antibody for IHC (f), IF - ABIN967738
Nishizuka: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. in Nature 1988
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Human Monoclonal PKC theta Primary Antibody for WB - ABIN968923
Soderling: Protein kinases. Regulation by autoinhibitory domains. in The Journal of biological chemistry 1990
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Human Polyclonal PKC theta Primary Antibody for IHC - ABIN966842
Xu, Chaudhary, Olland, Wolfrom, Czerwinski, Malakian, Lin, Stahl, Joseph-McCarthy, Benander, Fitz, Greco, Somers, Mosyak: Catalytic domain crystal structure of protein kinase C-theta (PKCtheta). in The Journal of biological chemistry 2004
Show all 2 Pubmed References
Human PKC theta Primary Antibody for IHC - ABIN966839
Bonny, Nicod, Waeber: IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. in The Journal of biological chemistry 1998
Human Monoclonal PKC theta Primary Antibody for ICS - ABIN1176929
Parker, Murray-Rust: PKC at a glance. in Journal of cell science 2003
The results indicate that PKC (show FYN Antibodies) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase (show DNAH8 Antibodies) by Ang II (show AGT Antibodies).
Phorbol 12-myristate 13-acetate activation of ERK (show MAPK1 Antibodies) and JNK (show MAPK8 Antibodies) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
PCR and transcriptome analysis suggest that the genes CD3D (show CD3D Antibodies) and PKRCQ together can be used as a model for differentiating between B-cell and T-cell acute lymphoblastic leukemia.
PKC-theta; is a critical factor for type 2 innate lymphoid cells activation that contributes to TH2 cell differentiation, which is associated with IRF4 (show IRF4 Antibodies) and NFAT1 (show NFAT1 Antibodies) expression in allergic lung inflammation.
Enhanced PRKCQ/PKCtheta; expression can promote growth-factor-independent growth, anoikis resistance, and migration. PRKCQ critically regulates growth and survival of a subset of TNBC.
Data suggest that, in T-lymphocytes, nitric oxide generated by eNOS (show NOS3 Antibodies) S-nitrosylates Cys374 on ACTB (show ACTB Antibodies) and thus regulates activation/recruitment of PRKCQ at immune synapse; S-nitrosylation of beta-actin (show ACTB Antibodies) impairs actin binding to PFN1 (show PFN1 Antibodies) and regulates protein transport in lamellipodia. (eNOS (show NOS3 Antibodies) = nitric oxide synthase (show NOS Antibodies) 3; ACTB (show ACTB Antibodies) = beta-actin (show ACTB Antibodies); PRKCQ = protein kinase C-theta; PFN1 (show PFN1 Antibodies) = profilin-1 (show PFN1 Antibodies))
PKCtheta;-induced phosphorylations control the ability of Fra-1 (show FOSL1 Antibodies) to stimulate gene expression and breast cancer cell migration.
Within the nucleus, PKC-theta; catalytic activity maintains the Ser536 phosphorylation on the p65 subunit of NF-kappaB (also known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition.
Data show that tonantzitlolone (TZL) was able to induce protein kinase c theta (PKCtheta;)-dependent heat shock transcription factor 1 (HSF1 (show HSF1 Antibodies))phosphorylation.
The PRKCQ polymorphism is not associated with Behcet's Disease.
Sumoylation of PKC-theta; was essential for T cell activation. Desumoylation did not affect the catalytic activity of PKC-theta; but inhibited the association of CD28 (show CD28 Antibodies) with PKC-theta; and filamin A (show FLNA Antibodies) and impaired the assembly of a mature immunological synapse.
Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A (show CORO1A Antibodies) on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB (show NFKB1 Antibodies) transactivation.
PKCtheta; selectively inactivates the negative regulator of F-actin generation, Coronin 1A (show CORO1A Antibodies), at the center of the T cell interface with the antigen presenting cell (APC (show APC Antibodies)). This allows for effective generation of the large actin-based lamellum required for recruitment of the Notch (show NOTCH1 Antibodies)-processing membrane metalloproteinase ADAM10 (show ADAM10 Antibodies).
Results suggest that while PKCtheta; is involved in Treg cell differentiation in vivo, it is dispensable for Treg-mediated suppression.
Data show that pharmacological inhibition of Protein Kinase C theta (PKCtheta;) in Duchenne Muscular Dystrophy (DMD (show DMD Antibodies)) can be considered an attractive strategy to modulate immune response and prevent the progression of the disease.
Knockdown of PKCtheta suppresses phosphorylation of IKK (show CHUK Antibodies) and JNK (show MAPK8 Antibodies) and consequently attenuates the HOCl-impaired insulin (show INS Antibodies) signaling pathway.
Data indicate that Protein kinase C theta; (PKCtheta;) is critical for stabilizing Th17 cell phenotype.
Data suggest that protein kinase (show CDK7 Antibodies) Ctheta (PKCtheta;) inhibition alone is insufficient for complete efficacy in rodent arthritis model.
Inhibition of PKC-theta preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
protein kinase C theta type
, PKC theta