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anti-Human PKC theta antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended PKC theta Antibody (supplied by: Log in to see )

Antigen
Protein Kinase C, theta (PRKCQ) Antibodies
  • A130035A12Rik
  • AW494342
  • nPKC-theta
  • PKC-0
  • PKC-theta
  • Pkcq
  • PKCtheta
  • PRKCT
Epitope
pThr538
41
41
37
9
9
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
194
116
107
4
4
4
4
Host
Rabbit
202
7
3
1
Clonality
Polyclonal
Conjugate
This PKC theta antibody is un-conjugated
5
5
5
3
3
3
3
3
3
3
3
3
3
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
150
107
72
33
32
28
5
3
2
2
1
1
1
Supplier
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Catalog No. ABIN711746
$ 291.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00087819446 ABIN876819 IF (p) Alexa Fluor 555 Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN876821 IF (p) Alexa Fluor 647 Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN876817 IF (p) Alexa Fluor 350 Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN876818 IF (p) Alexa Fluor 488 Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN912138 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN912140 IF (p) Alexa Fluor 647 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN912141 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN912142 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN711719 IF (p) Cy3 Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN711721 IF (p) Cy5.5 Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN711720 IF (p) Cy5 Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN711722 IF (p) Cy7 Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN711723 IF (p) FITC Rabbit IgG pSer676 Log in to see Polyclonal
0.00087819446 ABIN754741 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN754742 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN754743 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN754745 IF (p) FITC Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN754744 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN2805386 IF (p) Alexa Fluor 594 Rabbit IgG Log in to see Polyclonal
0.00087819446 ABIN2805564 IF (p) Alexa Fluor 594 Rabbit IgG pSer676 Log in to see Polyclonal

Similar anti-PKC theta Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine) Human
ELISA 23 Antibodies 25 Antibodies 70 Antibodies
Immunochromatography (IC) 2 Antibodies 2 Antibodies
Immunocytochemistry (ICC) 2 Antibodies 2 Antibodies
Immunofluorescence (IF) 21 Antibodies 21 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 34 Antibodies 34 Antibodies
Immunohistochemistry (IHC) 50 Antibodies 56 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 21 Antibodies 22 Antibodies
Immunoprecipitation (IP) 1 Antibodies
Western Blotting (WB) 70 Antibodies 76 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies

General

Antigen Protein Kinase C, theta (PRKCQ) Antibodies
Epitope pThr538
(41), (41), (37), (9), (9), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(194), (116), (107), (4), (4), (4), (4)
Host Rabbit
(202), (7), (3), (1)
Clonality
Polyclonal
Conjugate This PKC theta antibody is un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(150), (107), (72), (33), (32), (28), (5), (3), (2), (2), (1), (1), (1)
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Product Details anti-PKC theta Antibody

Target Details PKC theta Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human PRKCQ around the phosphorylation site of Thr538
Isotype IgG

Target Details PKC theta

Product Details anti-PKC theta Antibody Application Details Handling Images back to top
Antigen
Alternative Name Prkcq (PRKCQ Antibody Abstract)
Background

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response.

Subcellular location: Cytoplasm


Synonyms: PRKCT, nPKC-theta, Protein kinase C theta type, PRKCQ
Gene ID 5588
UniProt Q04759
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway

Application Details

Product Details anti-PKC theta Antibody Target Details PKC theta Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-PKC theta Antibody Target Details PKC theta Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-PKC theta Antibody Target Details PKC theta Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-PKC theta antibody (Protein Kinase C, theta) (pThr538) (ABIN711746) Formalin-fixed and paraffin embedded human endometrial carcinoma labeled with Anti-ph...