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The results indicate that PKC (show FYN Proteins) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase by Ang II (show AGT Proteins).
Phorbol 12-myristate 13-acetate activation of ERK (show MAPK1 Proteins) and JNK (show MAPK8 Proteins) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
Data show that tonantzitlolone (TZL) was able to induce protein kinase c theta (PKCtheta;)-dependent heat shock transcription factor 1 (HSF1 (show HSF1 Proteins))phosphorylation.
The PRKCQ polymorphism is not associated with Behcet's Disease.
Sumoylation of PKC-theta; was essential for T cell activation. Desumoylation did not affect the catalytic activity of PKC-theta; but inhibited the association of CD28 (show CD28 Proteins) with PKC-theta; and filamin A (show FLNA Proteins) and impaired the assembly of a mature immunological synapse.
Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A (show CORO1A Proteins) on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB (show NFKB1 Proteins) transactivation.
PKCtheta; acts through the activation of p38 MAPK (show MAPK14 Proteins) and autophagy induction. PKCtheta; acts through the activation of p38 MAPK (show MAPK14 Proteins) and autophagy induction to induce the Epstein-Barr virus (EBV) lytic cycle.
Data suggest that protein kinase C theta (PKCtheta;) inhibition alone may be sufficient to drive efficacy in chronic autoimmune and inflammatory diseases.
responsive to chemokine (show CCL1 Proteins) induced migration and are defective in migration to lymph nodes. Our results reveal a novel role for PKCtheta; in regulating T cell migration
protein kinase C-theta promotes Epithelial to mesenchymal transition by acting as a critical chromatin-anchored switch for inducible genes via transforming growth factor beta and the key inflammatory regulatory protein NF-kappaB (show NFKB1 Proteins).
Diacylglycerol activation of protein kinase (show CDK7 Proteins) Ctheta; and subsequent impairment of insulin (show INS Proteins) signaling plays a major role in the pathogenesis of muscle insulin (show INS Proteins) resistance in humans.
The results show that PKC-theta; has important diagnostic significance in gastrointestinal stromal tumors.
Data show that pharmacological inhibition of Protein Kinase C theta (PKCtheta;) in Duchenne Muscular Dystrophy (DMD (show DMD Proteins)) can be considered an attractive strategy to modulate immune response and prevent the progression of the disease.
Knockdown of PKCtheta suppresses phosphorylation of IKK (show CHUK Proteins) and JNK (show MAPK8 Proteins) and consequently attenuates the HOCl-impaired insulin (show INS Proteins) signaling pathway.
Data indicate that Protein kinase C theta; (PKCtheta;) is critical for stabilizing Th17 cell phenotype.
Data suggest that protein kinase (show CDK7 Proteins) Ctheta (PKCtheta;) inhibition alone is insufficient for complete efficacy in rodent arthritis model.
Inhibition of PKC-theta preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy
DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
Therefore, TCR ligation elicits a caspase (show CASP3 Proteins) cascade involving caspase-8 (show CASP8 Proteins), caspase-9 (show CASP9 Proteins) and caspase-3 (show CASP3 Proteins) which initiates PKC-theta;-dependent pathway leading to NF-kappaB (show NFKB1 Proteins) activation.
PKCtheta regulates myogenic and protein synthetic signaling via the modulation of IRS1 (show IRS1 Proteins) and ERK1 (show MAPK3 Proteins)/ERK2 (show MAPK1 Proteins) phosphorylation.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
protein kinase C theta type
, PKC theta