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Browse our PSTPIP1 Proteins (PSTPIP1)

Full name:
Proline-serine-threonine Phosphatase Interacting Protein 1 Proteins (PSTPIP1)
On www.antibodies-online.com are 6 Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) Proteins from 3 different suppliers available. Additionally we are shipping PSTPIP1 Antibodies (40) and PSTPIP1 Kits (3) and many more products for this protein. A total of 52 PSTPIP1 products are currently listed.
Synonyms:
CD2BP1, CD2BP1L, CD2BP1S, def-2, H-PIP, PAPAS, PSTPIP, PSTPIP1
list all proteins Gene Name GeneID UniProt
PSTPIP1 9051 O43586
PSTPIP1 19200 P97814
Rat PSTPIP1 PSTPIP1 300732  

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PSTPIP1 Proteins (PSTPIP1) by Origin

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More Proteins for PSTPIP1 Interaction Partners

Human Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) interaction partners

  1. PSTPIP1 was found to interact with pyrin (show MEFV Proteins) at the leading edge during cell migration.

  2. Molecular interactions between HPIP and FAK (show PTK2 Proteins), and HPIP and calpain2 regulate cell adhesion and migration through modulation of focal adhesion dynamics.

  3. Case Report: missense mutation in PSTPIP1, the gene responsible for PAPA (show PAPPA Proteins) syndrome.

  4. we have shown that PSTPIP1 regulates T-cell activation upon CD3 and CD28 stimulation, independently of CD2 costimulation. PSTPIP1 acts downstream of proximal TCR signaling, inhibiting several transcription factors.

  5. PSTPIP1 has a role in the pathogenesis of pyoderma gangrenosum through filopodia formation resulting in extracellular matrix degradation

  6. novel mutaations found in PSTPIP1 gene in patients with pyoderma gangrenosum

  7. The CCTG (show CCT3 Proteins) repeat in the PSTPIP1 promoter may play a role in the pathogenesis of aseptic abscess syndrome and Crohn's disease.

  8. CD2BP1-mediated biochemical pathway(s) may function in common inflammatory disorders with apparent etiological overlap, such as rheumatoid arthritis and inflammatory bowel disease

  9. PSTPIP1 acts downstream of CD2/CD2AP to link CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation.

  10. PSTPIP1/CD2BP1 protein binds to pyrin (show MEFV Proteins)

Mouse (Murine) Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1) interaction partners

  1. analysis of inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA (show PAPPA Proteins)) Syndrome-associated PSTPIP1 A230T mutant proteins

  2. the intracellular Fas ligand (FasL (show FASL Proteins)) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL (show FASL Proteins)

  3. PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration

PSTPIP1 Protein Profile

Protein Summary

The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.

Alternative names and synonyms associated with PSTPIP1

  • proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1)
  • proline-serine-threonine phosphatase interacting protein 1 (pstpip1)
  • proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1)
  • CD2BP1 protein
  • CD2BP1L protein
  • CD2BP1S protein
  • def-2 protein
  • H-PIP protein
  • PAPAS protein
  • PSTPIP protein
  • PSTPIP1 protein

Protein level used designations for PSTPIP1

proline-serine-threonine phosphatase interacting protein 1 , proline-serine-threonine phosphatase-interacting protein 1 , CD2 antigen-binding protein 1 , CD2 cytoplasmic tail-binding protein , CD2-binding protein 1 , PEST phosphatase-interacting protein 1

GENE ID SPECIES
415349 Gallus gallus
447609 Xenopus laevis
513924 Bos taurus
100050881 Equus caballus
100152628 Sus scrofa
100379705 Xenopus (Silurana) tropicalis
9051 Homo sapiens
19200 Mus musculus
300732 Rattus norvegicus
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