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Human RAP1A Protein expressed in Wheat germ - ABIN1317390
Chu, Awasthi, White, Chrzanowska-Wodnicka, Malarkannan: Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. in Journal of immunology (Baltimore, Md. : 1950) 2008
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RAP1 (show TERF2IP Proteins)-mediated MEK (show MAP2K1 Proteins)/ERK (show MAPK1 Proteins) pathway defects in Kabuki syndrome.
High RAP1 (show RABGEF1 Proteins) expression is associated with neuroblastoma (show ARHGEF16 Proteins).
Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated.
Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction
Unlike Rap1B (show RAP1B Proteins), phosphorylation in the polybasic region of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS (show RAP1GDS1 Proteins)-607.
SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 (show RABGEF1 Proteins) and R-Ras via the SPN (show SPN Proteins) domain and thus limiting their bioavailability at the plasma membrane.
These results suggest that Rap1 (show RABGEF1 Proteins) activation of ERKs requires PKA phosphorylation and KSR (show KSR1 Proteins) binding.
These data suggested that HBV-infection could up-regulate the expression of miR (show MLXIP Proteins)-203a, thus down regulated the expression of Rap1a.
Studies indicate that Rap (show LRPAP1 Proteins) interacting proteins decide the subcellular localization of Rap (show LRPAP1 Proteins), and the interaction modes with downstream Rap (show LRPAP1 Proteins) effectors.
A receptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway was identified as responsible for recruiting myosin IIB to the zonula adherens in epithelial cells and supporting contractile tension.
Rap1 (show RABGEF1 Proteins)- and Rac1-GTPase (show RACGAP1 Proteins) activation have roles in hypoxia/reoxygenation-experienced cancer cell migration and metastasis via the expression of thymosin beta-4 (show TMSB4X Proteins)
Rap1 (show TERF2IP Proteins) increases KRIT-1 (show KRIT1 Proteins) targeting to endothelial cell-cell junctions where it suppresses stress fibers and stabilizes junctional integrity.
the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse.
Results from comparative proteomics identified Rap1 as a novel legionella-containing-vacuole host component implicated in intracellular replication of Legionella pneumophila.
These results suggest that Rap1 (show TERF2IP Proteins) activation of ERKs requires PKA phosphorylation and KSR (show KSR1 Proteins) binding.
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature
Rap1 deficiency impaired T-cell homeostasis.
Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function
these data show that Treg degrade ATP to adenosine via CD39, attracting DC by activating Epac1-Rap1-dependent pathways.
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
RAP1A, member of RAS oncogene family
, ras-related protein Rap-1A
, GTP-binding protein smg p21A
, RAS-related protein RAP1A
, Ras-related protein Krev-1
, RAS-related protein 1a
, ras-related protein Krev-1
, GTP-binding protein smg-p21A
, GTP-binding protein SMG-P21A