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RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) ELISA Kits (RASGRP1)
On are 0 RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) ELISA Kits from different suppliers available. Additionally we are shipping RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) Antibodies (41) and RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) Proteins (4) and many more products for this protein. A total of 49 RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) products are currently listed.
list all ELISA KIts Gene Name GeneID UniProt
Mouse RASGRP1 RASGRP1 19419 Q9Z1S3
Human RASGRP1 RASGRP1 10125 O95267
Rat RASGRP1 RASGRP1 29434 Q9R1K8

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More ELISA Kits for RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) Interaction Partners

Mouse (Murine) RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) interaction partners

  1. RasGRP1/3-deficient progenitors show impaired migration toward the CCR9 (show CCR9 ELISA Kits) ligand, CCL25 (show CCL25 ELISA Kits), suggesting that RasGRP1 and RasGRP3 (show RASGRP3 ELISA Kits) may regulate progenitor entry into the thymus through a CCR9 (show CCR9 ELISA Kits)-dependent mechanism.

  2. RasGRP1 is indispensable for development of B1a cells with autoantigen receptors, revealing a connection between a signaling molecule and development of a specific repertoire within the B1a cell population

  3. Genetic Rasgrp1 depletion from mice with either an activating mutation in KRas or with aberrant Wnt (show WNT2 ELISA Kits) signalling due to a mutation in Apc (show APC ELISA Kits) resulted in both cases in exacerbated Ras-ERK (show EPHB2 ELISA Kits) signalling and cell proliferation.

  4. CD44 (show CD44 ELISA Kits) expression, CD4 (show CD4 ELISA Kits)(+) T cell subset ratios and serum autoantibodies all returned to normal in Rasgrp1(Anaef)Mtor (show FRAP1 ELISA Kits)(chino) double-mutant mice

  5. RasGRP1 upregulates signaling from Ras and contributes to epidermal tumorigenesis by increasing the total dosage of active Ras.

  6. autoreactive B cells lacking Rasgrp1 break central and peripheral tolerance through both T cell-independent and -dependent mechanisms.

  7. Dysregulated RasGRP1 responds to cytokine receptor (show LEPR ELISA Kits) input in T cell leukemogenesis.

  8. RasGRP1, but not RasGRP3 (show RASGRP3 ELISA Kits), is required for thymocyte positive selection and invariant natural killer T cell selection.

  9. Genetic analysis shows that disease progression and ERK (show EPHB2 ELISA Kits) signaling are dependent on RAS guanine exchange factor (show SOS1 ELISA Kits) responsible for ERK (show EPHB2 ELISA Kits) activation and lymphoproliferative phenotype in LAT (show LAT ELISA Kits)-Y136F mutant mice.

  10. While the DAG-binding C1 domain of RasGRP1 has long been recognized as an important factor mediating Erk (show EPHB2 ELISA Kits) activation, we have revealed the physiological relevance of the tail domain in RasGRP1 function and control of Erk (show EPHB2 ELISA Kits) signaling

Human RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) interaction partners

  1. Cytokines IL-2 (show IL2 ELISA Kits)/7/9 stimulation activates PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathways downstream of Ras in RasGRP1 T-cell acute lymphoblastic leukemia (T-ALL).

  2. results demonstrate the critical role of CalDAG-GEFI in rapid alphaIIbbeta3 activation of human platelets.

  3. This study shows that deficiency in RASGRP1 results in a previously unknown primary immunodeficiency disease, and that RASGRP1 plays role in immune cell signaling and function in T cells, B cells and NK cells. It also identifies a previously unknown role for RASGRP1 in the dynamic regulation of the cytoskeleton, and identify lenalidomide as a potpotential treatment option for this immunodeficiency.

  4. This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population.

  5. present a crystal structure of a fragment of RasGRP1 in which the Ras-binding site is blocked by an interdomain linker and the membrane-interaction surface of RasGRP1 is hidden within a dimerization interface

  6. A genome-wide association study identifies GRK5 (show GRK5 ELISA Kits) and RASGRP1 as type 2 diabetes loci in Chinese Hans.

  7. This is the first study aimed at evaluating CalDAG-GEFI gene sequences in people with mucocutaneous bleeding of unknown cause.

  8. PAQR10 (show MMD2 ELISA Kits) and PAQR11 (show MMD ELISA Kits) are able to interact with RasGRP1, a guanine nucleotide exchange protein (show EEF1D ELISA Kits) of Ras, and increase Golgi localization of RasGRP1. The C1 domain of RasGRP1 is both necessary and sufficient for the interaction of RasGRP1 with PAQR10 (show MMD2 ELISA Kits)/PAQR11 (show MMD ELISA Kits).

  9. cooperation between aberrant expression of RasGRP1, a strong activator of Ras, and secondary gain-of-function mutations of NOTCH1 (show NOTCH1 ELISA Kits) have an important role in T-cell leukemogenesis

  10. remission in systemic lupus erythematosus activity associated with decreased RasGRP-1 expression in lymphocytes

RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) Antigen Profile

Antigen Summary

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).

Alternative names and synonyms associated with RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1)

  • RAS guanyl releasing protein 1 (Rasgrp1) Elisa Kit
  • RAS guanyl releasing protein 1 (calcium and DAG-regulated) (RASGRP1) Elisa Kit
  • RAS guanyl releasing protein 1 (calcium and DAG-regulated) (Rasgrp1) Elisa Kit
  • CALDAG-GEFI Elisa Kit
  • CALDAG-GEFII Elisa Kit
  • hRasGRP1 Elisa Kit
  • RASGRP Elisa Kit
  • V Elisa Kit

Protein level used designations for RASGRP1

RAS guanyl-releasing protein 1 , calDAG-GEFII , calcium and DAG-regulated guanine nucleotide exchange factor II , RAS guanyl nucleotide-releasing protein 1 , guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A , ras activator RasGRP , CalDAG-GEF1

19419 Mus musculus
10125 Homo sapiens
29434 Rattus norvegicus
100522721 Sus scrofa
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