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|Antigen||SH2B Adaptor Protein 3 (SH2B3) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This SH2B3 antibody is conjugated to Alexa Fluor 488 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-SH2B3 AntibodyTarget Details SH2B3 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human LNK|
Target Details SH2B3Product Details anti-SH2B3 Antibody Application Details Handling Images back to top
|Alternative Name||Lnk (SH2B3 Antibody Abstract)|
APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.
Synonyms: IDDM20,Lymphocyte adapter protein,Lymphocyte specic adapter protein,Lymphocyte specic adapter protein Lnk,Lymphocyte-specic adapter protein Lnk,SH2B adapter protein 3,SH2B adaptor protein 3,Sh2b3,SH2B3_HUMAN,Signal transduction protein Lnk.
|Research Area||Signaling, Adaptive Immunity|
Application DetailsProduct Details anti-SH2B3 Antibody Target Details SH2B3 Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-SH2B3 Antibody Target Details SH2B3 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|