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anti-Mouse (Murine) SKAP1 Antibodies:
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Human Monoclonal SKAP1 Primary Antibody for IF, WB - ABIN968435
Liu, Kang, Raab, da Silva, Kraeft, Rudd: FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. in Proceedings of the National Academy of Sciences of the United States of America 1998
Show all 5 references for ABIN968435
Human Monoclonal SKAP1 Primary Antibody for IHC (p), ELISA - ABIN395949
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 5 references for ABIN395949
Human Monoclonal SKAP1 Primary Antibody for WB - ABIN394892
Raab, Wang, Lu, Smith, Wu, Strebhardt, Ladbury, Rudd: T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. in Immunity 2010
Show all 5 references for ABIN394892
Human Polyclonal SKAP1 Primary Antibody for ICC, IF - ABIN4353952
van Doorn, van Kester, Dijkman, Vermeer, Mulder, Szuhai, Knijnenburg, Boer, Willemze, Tensen: Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome. in Blood 2009
Human Polyclonal SKAP1 Primary Antibody for WB - ABIN2782452
Kosco, Cerignoli, Williams, Abraham, Mustelin: SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. in Molecular immunology 2007
In this study, the authors identified that the ADAP (show APP Antibodies)-SKAP55 signaling module reduced CD8 (show CD8A Antibodies)(+) cytotoxic T lymphocyte cytotoxicity and enhanced PD-1 (show PDCD1 Antibodies) expression in a Fyn (show FYN Antibodies)-, Ca(2 (show CA2 Antibodies)+)-, and NFATc1 (show NFATC1 Antibodies)-dependent manner.
Data suggest that the presence or absence of associated SKAP55 defines functionally distinct pools of ADAP (show APP Antibodies).
HPK1 (show MAP4K1 Antibodies) associates with SKAP1 to negatively regulate Rap1 (show TERF2IP Antibodies)-mediated B-lymphocyte (show AKAP17A Antibodies) adhesion.
SKAP1 is dispensable for both CXCL12 (show CXCL12 Antibodies) and CCL21 (show CCL21 Antibodies) induced T-cell migration.
findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL (show RASSF5 Antibodies) that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes.
Results identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal.
K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1 (show ITGAL Antibodies).
SKAP55 dimers stabilize SLP-76 (show LCP2 Antibodies) microclusters, couple SLP-76 (show LCP2 Antibodies) to the force-generating systems responsible for microcluster movement, and enable adhesion via the TCR by mechanisms independent of RIAM (show APBB1IP Antibodies), talin, and beta1 integrins.
single-nucleotide polymorphisms in ARRDC3, FLT1 (show FLT1 Antibodies), and SKAP1 were significant predictors for survival androgen-deprivation therapy in prostate cancer patients.
N-terminal myr-tagged SKAP1 for membrane binding facilitated constitutive RapL (show RASSF5 Antibodies) membrane and Rap1 (show RABGEF1 Antibodies) binding and effectively substituted for PI3K (show PIK3CA Antibodies) and TCR ligation in the activation of LFA-1 (show ITGAL Antibodies) in T cells.
Single nucleotide polymorphism in SKAP1 is associated with ovarian cancer.
SKAP55 coupled with CD45 (show PTPRC Antibodies) positively regulates T-cell receptor-mediated gene transcription.
observation that adapter protein (show TOLLIP Antibodies) SKAP55 formed homodimers through its SH3 domain (show ITSN1 Antibodies) and SK region
SKAP-55 regulates integrin-mediated adhesion and conjugate formation between T cells and antigen-presenting cells
stimuli that signal for the stabilization of SKAP55 may play an important role in T cell adhesion and conjugate formation
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
ortholog of human src family associated phosphoprotein 1 SCAP1
, src family-associated phosphoprotein 1
, src kinase-associated phosphoprotein 1
, src family associated phosphoprotein 1
, src kinase-associated phosphoprotein of 55 kDa
, SKAP55 adapter protein
, SKAP55 adaptor protein