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This study provides both genetic and functional evidence that transcellular epithelial calcium uptake via TRPV5-6 is vital to sustain life and enable bone formation.
These results suggest that the zECaC plays a key role in Ca(2 (show CA2 ELISA Kits)+) absorption in developing zebrafish.
TRPV6 and CaBP (show S100G ELISA Kits)-9k are expressed during pregnancy in the bovine uterine endometrium and placentomes, suggesting a functional role for these proteins in Ca2 (show CA2 ELISA Kits)+ metabolism during pregnancy.
TRPV5 (show TRPV5 ELISA Kits) and TRPV6 were upregulated with time and passage in culture suggesting that a shift in the phenotype of the cells in monolayer culture alters the expression of these channels.
TRPV6 mRNA levels were similar in the duodenum, kidney and heart of Equus caballus. Protein expression followed a similar pattern.
TRPV6 expression is significantly decreased in chondrocytes from patients with osteoarthritis of the knees. TRPV6 could regulate certain chondrocyte functions, including ECM secretion, cell proliferati (show MMRN1 ELISA Kits)on, and apoptosis.
The findings indicate that p38alpha (show MAPK14 ELISA Kits) and GADD45alpha (show GADD45A ELISA Kits) are involved in an enhanced vitamin D signaling on TRPV6 expression.
TRPV6 is down-regulated in esophageal squamous cell carcinoma and plays a role in predicting survival of male and female patients.
These results suggest that CAT-1 (show CRAT ELISA Kits) is a novel CAM (show CALM1 ELISA Kits) that directly regulates endothelial integrity and mediates the protective actions of L-Arg to endothelium via a NO-independent mechanism.
TRPV6 calcium ion channel plays a critical role in flow-induced Ca(2 (show CA2 ELISA Kits)+) influx and microvilli formation.
our results demonstrate that hCAT-1 (show SLC7A1 ELISA Kits) is a key component of efficient T-cell activation
TRPV6 and PLC (show HSPG2 ELISA Kits)-delta1 are critical actor of Ca(2 (show CA2 ELISA Kits)+) homeostasis in CF human bronchial epithelial cells.
focus on TRPV6 gene polymorphisms, the start of TRPV6 translation at a non-AUG codon and the functions of TRPV6 in intestinal Ca(2 (show CA2 ELISA Kits)+) uptake, sperm maturation, and male fertility.
TRPV6 channel acquires its oncogenic potential in prostate cancer due to the remodeling mechanism via the Orai1 (show ORAI1 ELISA Kits)-mediated calcium/Annexin I (show ANXA1 ELISA Kits)/S100A11 (show S100A11 ELISA Kits) pathway.
High TRPV6 expression is aassociated with adenoma of parathyroid glands.
Study showed that TRPV6-expressing elements seem to be discretely organized in the brain of mouse. TRPV6-immunoreactive arcuate neurons co-express estrogen receptor alpha (show ESR1 ELISA Kits) and the ion channel protein (show TRPC3 ELISA Kits) expression in the mediobasal hypothalamus showed correlation with estrous cycle.
TRPV6-/- mice spontaneously developed osteoarthritis at a younger age and had more severe manifestations of OA than wild-type controls. TRPV6 could regulate certain chondrocyte functions, including ECM (show MMRN1 ELISA Kits) secretion, cell proliferation, and apoptosis.
TRPV6 plays an essential role in bone metabolism and is a critical regulator in osteoclasts differentiation and bone resorption.
CAT1 (show SLC7A1 ELISA Kits) overexpression prevents obesity-induced hypertension by reducing the influence of the SNS (show SCN10A ELISA Kits) on the maintenance of arterial pressure but not by buffering pressor responses to stress.
Adra2a (show ADRA2A ELISA Kits) is expressed in the mesenchyme of the mouse stomach primordium at E11.5. Fzd5 and Trpv6 are expressed in the epithelial layer of the stomach primordium after E11.5.
these data indicate that obesity-induced down-regulation of CAT1 (show SLC7A1 ELISA Kits) expression and subsequent reduced bioavailability of nitric oxide may contribute to the development of obesity-induced hypertension.
Fibroblasts from two long-lived mice mutants (Snell dwarf (show POU1F1 ELISA Kits) and PAPP-A (show PAPPA ELISA Kits) knockout) expressed higher levels of CAT1 (show SLC7A1 ELISA Kits) (a ATF4 (show ATF4 ELISA Kits) target gene) during stress, suggesting a connection to longevity.
A non-AUG start codon is used in both human and mouse, extending the N-terminus of the protein by 40 amino acids. The increased translation of the smaller TRPV6 cDNA version may overestimate the in vivo situation where translation efficiency may represent an additional mechanism to tightly control the TRPV6-mediated Ca(2 (show CA2 ELISA Kits)+) entry to prevent deleterious Ca(2 (show CA2 ELISA Kits)+) overload.
Augmented endothelial l-arginine (show GATM ELISA Kits) transport attenuated the prohypertensive effects of systemic and renal oxidative stress, suggesting that manipulation of endothelial CAT1 (show SLC7A1 ELISA Kits) may provide a new therapeutic approach for the treatment of cardiovascular disease.
This gene encodes a member of the vanilloid family of transient receptor potential (TRP) calcium channel proteins. Proteins in this TRP family have an N-terminal ankyrin repeat domain, which is required for channel assembly and regulation.
epithelial calcium channel
, transient receptor potential cation channel subfamily V member 6
, transient receptor potential vanilloid 5-6
, transient receptor potential cation channel, subfamily V, member 6
, Alu-binding protein with zinc finger domain
, calcium transport protein 1
, calcium transporter-like protein
, epithelial apical membrane calcium transporter/channel CaT1
, epithelial calcium channel 2
, osmosensitive transient receptor potential channel 3
, transient receptor potential cation channel, subfamily 5, member 6